Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis

LIU Li

doi:10.16766/j.cnki.issn.1674-4152.002604

Volume 20 Issue 8

Aug. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(8): 1388-1391

LIU Li. Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis[J]. Chinese Journal of General Practice, 2022, 20(8): 1388-1391. doi: 10.16766/j.cnki.issn.1674-4152.002604

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LIU Li. Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis[J]. Chinese Journal of General Practice, 2022, 20(8): 1388-1391. doi: 10.16766/j.cnki.issn.1674-4152.002604

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Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis

doi: 10.16766/j.cnki.issn.1674-4152.002604

LIU Li

Department of Gastroenterology, Ganzhou People ' s Hospital, Ganzhou, Jiangxi 341000, China

Received Date: 2021-09-12
Available Online: 2022-09-26

Abstract

Abstract

Anxiety and depression are physical disorders caused by stress response or bad emotions. They are diseases in which psychological and physical symptoms coexist caused by the combined action of biological, psychological and social factors. They are the most common psychological diseases in contemporary society. They not only reduce the quality of life of an individual, but also bring huge economic burden to the family and society. In recent years, with the maturity of high-throughput sequencing, sequence recognition technology and intestinal metagenomics, the role of intestinal microbes has been widely recognised and valued. There is a complex two-way communication between the intestine and the central nervous system, which is finely orchestrated by multiple systems such as endocrine, immune and enteric nervous systems. Therefore, the intestine is also known as the "second brain" of the human body. Previous studies have shown that intestinal microbes may act as initiators of the micro-inflammatory response state, which mediates the imbalance of intestinal homeostasis, leading to "bacteria-gut-brain" dysfunction, which plays an important role in the onset of anxiety and depression. However, the specific pathogenic mechanism is currently unclear. As the largest endocrine organ of the human body, the intestine can secrete dozens of different signal molecules, mostly peptides. Intestinal peptides secreted into the systemic circulation can bind to immune cells and homologous receptors on the vagus nerve endings, thereby realising indirect intestinal-brain communication. Therefore, this article summarises the influence of intestinal peptides as signal molecules of the bacteria-gut-brain axis on anxiety and depression, in order to provide a certain basis and reference for the clinical diagnosis and treatment of anxiety and depression. Changing psychological diseases such as depression and anxiety by regulating intestinal microbes has become a hot topic in neuroscience and psychology. Maintaining a good intestinal flora may be an important direction for the prevention and treatment of depression and anxiety in the future.
- Intestinal peptides,
- Anxiety,
- Depression,
- Microbiota-gut-brain axis

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References(43)

References

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Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis

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Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis

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