Volume 20 Issue 9
Sep.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(9): 1458-1461
YANG Li-ping, WU Ai-lin, ZHOU Yan, TAO Zhen-chao, HE Jian, YANG Jing, ZHANG Yang-yang, QIAN Li-ting, GAO Jin. Effect of NLR and PLR from pre-radiotherapy on prognosis of locally advanced nasopharyngeal carcinoma patients[J]. Chinese Journal of General Practice, 2022, 20(9): 1458-1461. doi: 10.16766/j.cnki.issn.1674-4152.002622
Citation: YANG Li-ping, WU Ai-lin, ZHOU Yan, TAO Zhen-chao, HE Jian, YANG Jing, ZHANG Yang-yang, QIAN Li-ting, GAO Jin. Effect of NLR and PLR from pre-radiotherapy on prognosis of locally advanced nasopharyngeal carcinoma patients[J]. Chinese Journal of General Practice, 2022, 20(9): 1458-1461. doi: 10.16766/j.cnki.issn.1674-4152.002622
shu

Effect of NLR and PLR from pre-radiotherapy on prognosis of locally advanced nasopharyngeal carcinoma patients

doi: 10.16766/j.cnki.issn.1674-4152.002622

  • Department of Head and Neck Radiotherapy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China

Funds:

 11805198

  • Received Date: 2022-01-25
    Available Online: 2022-11-29
    Abstract
  •   Objective  To explore the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) and the prognosis of patients with locally advanced nasopharyngeal carcinoma undergoing radiotherapy.  Methods  We retrospectively analysed the clinical data and follow-up data of 60 patients with locally advanced nasopharyngeal carcinoma who underwent radiotherapy and chemotherapy from January 2016 to December 2018. An ROC curve was used to determine NLR and PLR. According to the best cutoff value, patients were divided into high-and low-level groups. Chi-square or Fisher exact test was used to compare the differences between groups. Kaplan-Meier method was used to draw survival curve. Cox regression model was used for univariate and multivariate analysis.  Results  According to the ROC curve, the best cutoff values of NLR and PLR before radiotherapy were 1.99 and 154.94, respectively. In univariate analysis, N stage, clinical stage, pre-radiotherapy NLR and PLR were related to patient prognosis (all P < 0.05). The average survival time of the low pre-radiotherapy NLR group was (62.26±1.88) months, which was better than that of the high NLR group of (51.17±3.94) months (P=0.048). Compared with the high pre-radiotherapy PLR group, the average survival time of the low PLR group was longer (P=0.014). Cox multivariate analysis showed that clinical stage, N stage, and pre-radiotherapy PLR level were independent prognostic factors for patient survival (all P < 0.05).  Conclusion  PLR before radiotherapy could be used as an independent prognostic predictor for patients with locally advanced nasopharyngeal carcinoma undergoing radiotherapy. It is recommended as an auxiliary method for evaluating the prognosis of patients.

     

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