Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis

NIU Kai-xuan; WU Shu-lu; LIU Cheng; DENG Xi-ming

doi:10.16766/j.cnki.issn.1674-4152.002629

Volume 20 Issue 9

Sep. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(9): 1484-1487

NIU Kai-xuan, WU Shu-lu, LIU Cheng, DENG Xi-ming. Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis[J]. Chinese Journal of General Practice, 2022, 20(9): 1484-1487. doi: 10.16766/j.cnki.issn.1674-4152.002629

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NIU Kai-xuan, WU Shu-lu, LIU Cheng, DENG Xi-ming. Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis[J]. Chinese Journal of General Practice, 2022, 20(9): 1484-1487. doi: 10.16766/j.cnki.issn.1674-4152.002629

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Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis

doi: 10.16766/j.cnki.issn.1674-4152.002629

Department of Critical Care Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

2019-54

KJ2019A0351

Received Date: 2022-04-05
Available Online: 2022-11-29

Abstract

Abstract

Objective To explore the significance of serum amyloid A (SAA) and interleukin-6 (IL-6) in the diagnosis and severity evaluation of sepsis. Methods A total of 80 patients in the Department of Critical Care Medicine of the First Affiliated Hospital of Bengbu Medical College from October 1, 2020 to May 31, 2021 were selected, and scores of SAA, IL-6, procalcitonin (PCT), C-reactive protein (CRP), APACHE Ⅱ and SOFA were collected within 24 hours from admission. According to the diagnostic criteria of sepsis, 25 cases were divided into the non-sepsis group and 55 cases were divided into the sepsis group. The diagnostic efficacy of SAA and IL-6 in sepsis was evaluated by ROC curve, while the correlation between SAA, IL-6 and APACHE Ⅱ score, SOFA score was explored by Spearman analysis. According to the diagnostic criteria of septic shock, patients with sepsis were divided into the common sepsis group (n=25) and the septic shock group (n=30), and the judgment value of SAA and IL-6 on the severity of the disease was evaluated. Results The ROC curve for the diagnosis of sepsis showed high sensitivity and specificity of IL-6 (94.4%, 63.4%). SAA combined with PCT had the highest specificity (95.8%). IL-6 combined with CRP had the highest sensitivity (100.0%). SAA and IL-6 were positively correlated with APACHE Ⅱ score and SOFA score. The ROC results to assess the severity of the disease showed that the specificity of SAA alone and IL-6 combined with PCT was the highest (both 80.0%), and the sensitivity of SAA combined with PCT was the highest (96.0%). Conclusion SAA and IL-6 can be used as effective markers to evaluate the severity of sepsis, and IL-6 can also assist in the early diagnosis of sepsis. The combination of SAA and IL-6 with PCT and CRP can improve the clinical value.
- Sepsis,
- Septic shock,
- Serum amyloid A,
- Interleukin 6,
- Early diagnosis,
- Severity of illness

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References

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Clinical value of serum amyloid A and interleukin-6 in the diagnosis and severity evaluation of sepsis

doi: 10.16766/j.cnki.issn.1674-4152.002629