Volume 20 Issue 10
Oct.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(10): 1801-1804
WU Zu-xia, ZUO Qiong, LIU Rui, WANG Xing-bing. Consistency of self-evaluation and nursing records in patients with cytokine release syndrome after CAR-T cell therapy for haematological tumours[J]. Chinese Journal of General Practice, 2022, 20(10): 1801-1804. doi: 10.16766/j.cnki.issn.1674-4152.002706
Citation: WU Zu-xia, ZUO Qiong, LIU Rui, WANG Xing-bing. Consistency of self-evaluation and nursing records in patients with cytokine release syndrome after CAR-T cell therapy for haematological tumours[J]. Chinese Journal of General Practice, 2022, 20(10): 1801-1804. doi: 10.16766/j.cnki.issn.1674-4152.002706
shu

Consistency of self-evaluation and nursing records in patients with cytokine release syndrome after CAR-T cell therapy for haematological tumours

doi: 10.16766/j.cnki.issn.1674-4152.002706

  • The First Ward of Hematology Department, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, China

Funds:

 82170221

 18030801126

  • Received Date: 2022-03-12
    Available Online: 2022-11-30
    Abstract
  •   Objective  To explores the consistency of self-evaluation and nursing records of patients with cytokine release syndrome (CRS) after chimeric antigen receptor T (CAR-T) cell therapy of haematological tumours.  Methods  A total of 39 patients with haematological tumours who developed CRS symptoms requiring clinical intervention after CAR-T cell therapy in the First Affiliated Hospital of University of Science and Technology of China from October 2016 to October 2018 were selected. The self-assessment of symptoms, including nausea, vomiting, dyspnea, myalgia, headache, rash, fatigue and loss of appetite, were summarised using a standardised questionnaire and then compared with the CRS symptom scores in the nursing records using the Wilcoxon rank-sum test and further analysed using an intraclass correlation coefficient (ICC) to explore the consistency between the two.  Results  Except rash (Z=1.388, P=0.165), the self-reported CRS symptoms of patients, nausea, vomiting, dyspnea, myalgia, headache, fatigue and loss of appetite were significantly higher than the data in nursing records (all P < 0.001). Similarly, in the patient self-assessment, except rash, the consistency was appropriate (ICC=0.55, P < 0.001), and the other items were low with the nursing assessment data measurement (0.21 < ICC < 0.40, all P < 0.05).  Conclusion  The nurses ' evaluation of CRS patients after CAR-T cell therapy of haematological tumours is not consistent with the patient ' s self-evaluation, and their nursing evaluation still needs to be further summarised.

     

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