Volume 20 Issue 11
Nov.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(11): 1860-1862
XIE Zhong-hai, LI Hong-wei, ZANG Jin, MIN Wei-wei. Investigation of clinical characteristics and prognostic factors in patients with non-small cell lung cancer after radical resection[J]. Chinese Journal of General Practice, 2022, 20(11): 1860-1862. doi: 10.16766/j.cnki.issn.1674-4152.002720
Citation: XIE Zhong-hai, LI Hong-wei, ZANG Jin, MIN Wei-wei. Investigation of clinical characteristics and prognostic factors in patients with non-small cell lung cancer after radical resection[J]. Chinese Journal of General Practice, 2022, 20(11): 1860-1862. doi: 10.16766/j.cnki.issn.1674-4152.002720
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Investigation of clinical characteristics and prognostic factors in patients with non-small cell lung cancer after radical resection

doi: 10.16766/j.cnki.issn.1674-4152.002720

  • Department of Cardiothoracic Surgery, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2022RC261

  • Received Date: 2022-03-15
    Available Online: 2022-12-30
    Abstract
  •   Objective  To explore the clinical characteristics and prognostic factors of patients with non-small cell lung cancer after radical resection, and provide a theoretical basis for the formulation of prognostic intervention programs for patients.  Methods  A total of 514 patients who underwent radical resection of non-small cell lung cancer in Huzhou Central Hospital from January 2013 to December 2016 were selected as the research subjects. The postoperative clinical characteristics of the patients were counted, and the multivariate regression method was used to analyse the factors affecting the prognosis of patients with non-small cell lung cancer after radical resection.  Results  The clinical characteristics of 514 patients with non-small cell lung cancer after radical resection showed that the lesions were located in the right lung in 292 cases (56.81%) and in the left lung in 222 cases (43.19%). Histological types were mainly adenocarcinoma in 284 cases (55.25%) and squamous cell carcinoma in 206 cases (40.08%). Meanwhile, 305 cases (59.34%) had postoperative distant organ metastasis. Degree of tumour differentiation: 286 cases (55.64%) with low differentiation, 228 cases (44.36%) with moderate/high differentiation. Clinical TNM staging: 418 cases (81.32%) of stages Ⅰ-Ⅱ and 96 cases (18.68%) of stages Ⅲ-Ⅳ. The results of multivariate regression analysis showed that tumour diameter ≥ 3 cm, distant organ metastasis after the operation, medium/well-differentiated tumour, stages Ⅲ-Ⅳ, and no chemotherapy after operation were the prognostic influencing factors for patients with non-small cell lung cancer after radical resection (all P < 0.05).  Conclusion  Tumour diameter of ≥ 3 cm, distant organ metastasis after the operation, poorly differentiated tumour, stages Ⅲ-Ⅳ, and no postoperative chemotherapy are independent factors affecting the postoperative prognosis of patients with non-small cell lung cancer. Therefore, relevant prevention should be actively carried out in clinical practice to improve the quality of life of patients with non-small cell lung cancer after radical resection.

     

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    • References(18)
  • [1]
    李婵, 李涛. 老年非小细胞肺癌患者预后影响因素分析[J]. 中华肿瘤防治杂志, 2020, 27(22): 1844-1849. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL202022013.htm

    LI C, LI T. Analysis of prognostic factors in elderly patients with non-small cell lung cancer[J]. Chinese Journal of Cancer Prevention and Treatment, 2020, 27(22): 1844-1849. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL202022013.htm
    [2]
    罗汶鑫, 胡丹婧, 李为民. 年轻非小细胞肺癌的临床病理特征及预后研究[J]. 中国呼吸与危重监护杂志, 2020, 19(5): 483-488. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGHW202005017.htm

    LUO W X, HU D J, LI W M. The clinicopathological characteristics and prognosis of young patients with non-small cell lung cancer[J]. Chinese Journal of Respiratory and Critical Care Medicine, 2020, 19(5): 483-488. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGHW202005017.htm
    [3]
    TAKEUCHI M, NAKACHI I, FUJISAWA D, et al. Longitudinal assessment of prognostic understanding in patients with advanced lung cancer and its association with their psychological distress[J]. Oncologist, 2021, 26(12): 2265-2273. doi: 10.1002/onco.13973
    [4]
    马春柳, 李小升, 周伟, 等. 50岁及以上非小细胞肺癌患者预后影响因素调查研究[J]. 实用肿瘤杂志, 2021, 36(6): 525-530. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZZ202106010.htm

    MA C L, LI X S, ZHOU W, et al. Study on prognostic factors of non-small-cell lung cancer patients aged 50 years and over[J]. Journal of Practical Oncology, 2021, 36(6): 525-530. https://www.cnki.com.cn/Article/CJFDTOTAL-SYZZ202106010.htm
    [5]
    中华医学会. 《临床诊疗指南·肿瘤分册》[M]. 北京: 人民卫生出版社, 2005.

    Chinese Medical Association. Clinical diagnosis and treatment guidelines, tumor volume[M]. Beijing: People's Health Publishing House, 2005.
    [6]
    陈嫱, 英硕, 李冠华, 等. 非小细胞肺癌M1期患者的危险、预后因素和转移特征: 一项基于SEER数据库的研究[J]. 天津医科大学学报, 2022, 28(1): 27-34. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYK202201007.htm

    CHEN Q, YING S, LI G H, et al. The risk, prognostic factors and metastatic features for patients with M1 stage of non-small cell lung cancer: A SEER-based study[J]. Journal of Tianjin Medical University, 2022, 28(1): 27-34. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYK202201007.htm
    [7]
    宋冠初, 郭根燕, 陆永涛, 等. 110例局部非小细胞肺癌手术治疗的预后分析[J]. 现代肿瘤医学, 2020, 28(10): 1659-1663. doi: 10.3969/j.issn.1672-4992.2020.10.011

    SONG G C, GUO G Y, LU Y T, et al. Analysis of clinicopathological features and prognostic factors in 110 patients with non-small cell lung cancer[J]. Journal of Modern Oncology, 2020, 28(10): 1659-1663. doi: 10.3969/j.issn.1672-4992.2020.10.011
    [8]
    褚翔宇, 王纪文, 高志. 老年早期非小细胞肺癌术后生存的影响因素[J]. 中华胸心血管外科杂志, 2021, 37(8): 509-512. doi: 10.3760/cma.j.cn112434-20200207-00030

    CHU X Y, WANG J W, GAO Z. Review of risk factors influencing the postoperative survival of elderly patients with early-staged non-small cell lung cancer[J]. Chinese Journal of Thoracic and Cardiovascular Surgery, 2021, 37(8): 509-512. doi: 10.3760/cma.j.cn112434-20200207-00030
    [9]
    张炳太, 张雷, 刘军, 等. 胸腔镜下肺叶与肺段切除术治疗早期非小细胞肺癌的临床效果观察[J]. 中华全科医学, 2022, 20(3): 399-402. doi: 10.16766/j.cnki.issn.1674-4152.002362

    ZHANG B T, ZHANG L, LIU J, et al. Clinical effect observation of thoracoscopic lobectomy and segmentectomy in the treatment of early non-small cell lung cancer[J]. Chinese Journal of General Practice, 2022, 20(3): 399-402. doi: 10.16766/j.cnki.issn.1674-4152.002362
    [10]
    宋洋, 夏冰, 吴岳光. 肺癌患者肺部感染的相关临床危险因素分析[J]. 中华全科医学, 2021, 19(3): 354-357, 462. doi: 10.16766/j.cnki.issn.1674-4152.001808

    SONG Y, XIA B, WU Y G. Analysis of related clinical risk factors of lung infection in patients with lung cancer[J]. Chinese Journal of General Practice, 2021, 19(3): 354-357, 462. doi: 10.16766/j.cnki.issn.1674-4152.001808
    [11]
    孙翠翠, 张斯萌, 温倜, 等. 晚期非小细胞肺癌肿瘤生长速率与临床病理特征及预后的相关性[J]. 中国医科大学学报, 2019, 48(8): 673-677. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYK201908001.htm

    SUN C C, ZHANG S M, WEN T, et al. Correlation between tumor growth rate and clinicopathological features and prognosis in advanced non-small cell lung cancer[J]. Journal of China Medical University, 2019, 48(8): 673-677. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYK201908001.htm
    [12]
    SOYKUT E D, KEMAL Y, KARACIN C, et al. Prognostic impact of immune inflammation biomarkers in predicting survival and radiosensitivity in patients with non-small-cell lung cancer treated with chemoradiotherapy[J]. J Med Imaging Radiat Oncol, 2022, 66(1): 146-157.
    [13]
    郭根军, 刘尚国, 张俊杰, 等. 非小细胞肺癌脉管癌栓的相关性分析及对手术后预后的影响[J]. 现代肿瘤医学, 2021, 29(13): 2265-2268. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZL202113013.htm

    GUO G J, LIU S G, ZHANG J J, et al. Correlation analysis of vascular tumor thrombus in non-small cell lung cancer and its influence on postoperative prognosis[J]. Journal of Modern Oncology, 2021, 29(13): 2265-2268. https://www.cnki.com.cn/Article/CJFDTOTAL-SXZL202113013.htm
    [14]
    张云魁, 张荣生, 张羽捷. 非小细胞肺癌患者手术治疗预后影响因素分析[J]. 肿瘤研究与临床, 2019, 31(3): 209-213. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201721010.htm

    ZHANG Y K, ZHANG R S, ZHANG Y J. Prognostic influencing factors analysis of patients with non-small cell lung cancer after surgery[J]. Cancer Research and Clinic, 2019, 31(3): 209-213. https://www.cnki.com.cn/Article/CJFDTOTAL-QLZL201721010.htm
    [15]
    唐中豪, 林开, 李向阳, 等. 非小细胞肺癌患者临床疗效及预后的影响因素[J]. 老年医学与保健, 2021, 27(2): 245-249. https://www.cnki.com.cn/Article/CJFDTOTAL-LYBJ202102011.htm

    TANG Z H, LIN K, LI X Y, et al. Study of clinical therapeutic efficacy and prognostic factors in patients with non-small cell lung cancer[J]. Geriatrics & Health Care, 2021, 27(2): 245-249. https://www.cnki.com.cn/Article/CJFDTOTAL-LYBJ202102011.htm
    [16]
    HUANG W H, ZHANG H, ZHANG Z W, et al. A prognostic nomogram based on a new classification of combined micropapillary and solid components for stage ⅠA invasive lung adenocarcinoma[J]. J Surg Oncol, 2022, 125(4): 796-808.
    [17]
    张爽, 胡月华, 娄桂珍. 同步放化疗治疗Ⅲ期不可切除老年非小细胞肺癌的临床效果及预后因素分析[J]. 实用癌症杂志, 2022, 37(5): 769-771, 776. https://www.cnki.com.cn/Article/CJFDTOTAL-SYAZ202205018.htm

    ZHANG S, HU Y H, LOU G Z. Clinical effect and prognostic factors of simultaneous radiotherapy and chemotherapy in the treatment of stage Ⅲ unresectable elderly non-small cell lung cancer[J]. The Practical Journal of Cancer, 2022, 37(5): 769-771, 776. https://www.cnki.com.cn/Article/CJFDTOTAL-SYAZ202205018.htm
    [18]
    冯婷婷, 陈众众, 闫文锦, 等. 基于SEER数据库的肿瘤直径大于7.0厘米的非小细胞肺癌患者预后分析[J]. 肿瘤防治研究, 2021, 48(1): 49-54. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLFY202101010.htm

    FENG T T, CHEN Z Z, YAN W J, et al. Prognosis analysis of non-small cell lung cancer with diameter over 7.0 cm based on SEER Database[J]. Cancer Research on Prevention and Treatment, 2021, 48(1): 49-54. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLFY202101010.htm
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