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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2006-2009
ZHANG Fang, CHEN Guo-fan, REN Kai-han, WANG Ming-wei. Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2006-2009. doi: 10.16766/j.cnki.issn.1674-4152.002756
Citation: ZHANG Fang, CHEN Guo-fan, REN Kai-han, WANG Ming-wei. Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2022, 20(12): 2006-2009. doi: 10.16766/j.cnki.issn.1674-4152.002756
shu

Effects of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.002756

  • Cardiovascular Department, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, China

Funds:

 2021KY890

  • Received Date: 2021-04-14
    Available Online: 2023-02-07
    Abstract
  •   Objective  To analyze the effect of Shexiang Baoxin Pills on cardiac function, ventricular remodeling and vascular endothelial factor in elderly patients with chronic heart failure (CHF), so as to provide reference for clinical treatment of CHF.  Methods  A total of 100 elderly patients with CHF in the Affiliated Hospital of Hangzhou Normal University from January 2018 to December 2019 were selected and divided into control group and observation group by random digital table method, 50 cases in each group. The control group was treated with conventional western medicine, and the observation group was treated with western medicine combined with Shexiang Baoxin Pills. The cardiac function, ventricular remodeling, hemodynamics, endothelial cell function and adverse reactions were compared between the two groups.  Results  After treatment, the levels of left ventricular ejection fraction, 6 min walking test, cardiac index in the two groups were significantly higher than those before treatment (all P < 0.05), and those in the observation group were significantly higher than those in the control group [(52.16±3.39) % vs. (44.24±4.73) %, (453.46±23.20) m vs. (417.25±22.52) m, (3.34±0.38) L/(min·m2) vs. (2.88±0.46) L/(min·m2), t=9.624, 7.919, 5.452, all P < 0.05]. After treatment, the levels of the left ventricular end diastolic diameter, left ventricular posterior wall thickness, interventricular septal end systolic thickness, left ventricular mass index, pulmonary artery wedge pressure, total peripheral resistance, angiotensin Ⅱ, aldosterone, endothelin-1 in the two groups were significantly lower than those before treatment (all P < 0.05), and the observation group were significantly lower than the control group (t=7.440, 7.083, 3.733, 6.272, 12.507, 11.399, 9.234, 7.876, 10.218, all P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.444, P>0.05).  Conclusion  Shexiang Baoxin Pills can effectively improve endothelial function, cardiac function and hemodynamics in elderly patients with CHF, delay ventricular remodeling, and has good safety.

     

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    • References(20)
  • [1]
    祁玮, 宋丽萍, 刘志霆, 等. 八段锦对慢性心力衰竭患者心功能及生活质量的影响[J]. 北京医学, 2020, 42(3): 263-265. https://www.cnki.com.cn/Article/CJFDTOTAL-BJYX202003031.htm
    [2]
    GAO P, WU X, ZHANG F H, et al. Efficacy of Shenmai injection for the treatment of chronic heart failure: A protocol of systematic review[J]. Medicine (Baltimore), 2020, 99(26): e20663. DOI: 10.1097/MD.0000000000020663.
    [3]
    WU L Y, ZHANG Q, SHU Q H, et al. Sex-dependent changes in physical, mental, and quality of life outcomes in metoprolol-treated Chinese chronic heart failure patients[J]. Medicine (Baltimore), 2019, 98(50): e18331. DOI: 10.1097/MD.0000000000018331.
    [4]
    刘淑荣, 张晓华, 钱锋, 等. 强心康颗粒治疗慢性心力衰竭的临床研究[J]. 中华全科医学, 2019, 17(3): 364-366. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201903007.htm
    [5]
    熊巍, 叶华, 佘姝娅, 等. 麝香保心丸联合阿托伐他汀治疗急性心肌梗死的疗效观察[J]. 世界中医药, 2018, 13(5): 1198-1201. doi: 10.3969/j.issn.1673-7202.2018.05.037
    [6]
    中华医学会心血管病学分会心力衰竭学组, 中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志, 2018, 46(10): 760-789. doi: 10.3760/cma.j.issn.0253-3758.2018.10.004
    [7]
    贺立山, 翁孝刚. 内科学[M]. 7版. 西安: 第四军医大学出版社, 2008.
    [8]
    孔繁达, 张艳, 朱爱松, 等. 补肾活血中药对慢性心力衰竭大鼠Klotho蛋白及心肌细胞形态的影响[J]. 中华中医药学刊, 2019, 37(3): 619-623. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS201903026.htm
    [9]
    SESSA M, RASMUSSEN D B, JENSEN M T, et al. Metoprolol versus carvedilol in patients with heart failure, chronic obstructive pulmonary disease, diabetes mellitus, and renal failure[J]. Am J Cardiol, 2019, 125(7): 1069-1076.
    [10]
    高玲, 杨婷, 王迪, 等. 强心活力方对慢性心力衰竭大鼠IL-6、TNF-α含量及NF-κB表达的影响[J]. 中华中医药杂志, 2018, 33(3): 1070-1073. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201803072.htm
    [11]
    刘琛怡, 李济廷, 卢洁, 等. 四逆汤合参附汤治疗慢性心力衰竭阳虚血瘀证[J]. 长春中医药大学学报, 2018, 34(4): 715-718. https://www.cnki.com.cn/Article/CJFDTOTAL-CZXX201804032.htm
    [12]
    赵娜, 齐新. 芪苈强心胶囊治疗慢性心力衰竭的临床疗效观察[J]. 中西医结合心脑血管病杂志, 2018, 16(8): 1001-1004. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY201808003.htm
    [13]
    吕永飞, 吴桂玲, 孙玮琦, 等. 真武四物汤足浴联合中药穴位贴敷治疗慢性心衰对血液流变学指标的影响[J]. 世界中西医结合杂志, 2020, 15(4): 760-762, 778. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZX202004044.htm
    [14]
    刘亚红, 赵越娟. 生脉养心汤配合内关穴针刺对慢性心力衰竭患者心功能、炎性因子的影响[J]. 中医药信息, 2020, 37(1): 88-92. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXN202001022.htm
    [15]
    董珊珊. 舒适护理对美托洛尔治疗老年慢性心力衰竭的疗效及生活质量和心功能的影响[J]. 中国现代医生, 2019, 57(34): 161-163. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS201934049.htm
    [16]
    ROUL G, GERMAIN P, BAREISS P. Does the 6-minute walk test predict the prognosis in patients with NYHA class Ⅱ or Ⅲ chronic heart failure?[J]. Am Heart J, 1998, 136(3): 449-457.
    [17]
    刘颖, 董京京, 江涛, 等. 麝香保心丸联合缬沙坦治疗慢性心力衰竭的临床研究[J]. 现代药物与临床, 2020, 35(4): 730-734. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202004028.htm
    [18]
    徐素容, 谢成琴, 罗娅, 等. 磷酸肌酸钠联合麝香保心丸对慢性心力衰竭患者心功能和心室重构的影响[J]. 中华实用诊断与治疗杂志, 2019, 33(4): 366-368. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201904016.htm
    [19]
    KUSTER G M, PFISTER O. Chronic heart failure: Advances in pharmacological treatment and future perspectives[J]. Swiss Med Wkly, 2019, 149: w20036. DOI: 10.4414/smw.2019.20036.
    [20]
    王彦斌, 陈小平, 任素芳, 等. 麝香保心丸联合曲美他嗪对缺血性心肌病心力衰竭患者的临床疗效[J]. 中国药物与临床, 2019, 19(3): 410-411. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC201903032.htm
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