Volume 20 Issue 12
Dec.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(12): 2034-2037
CHEN Nian-ping, HOU Hai-yan, QIU Yuan-li, SONG Cheng, ZHU Ya-fang, XU Liang. Application of nalbuphine combined with dexmedetomidine in painless ultrasound bronchoscopy[J]. Chinese Journal of General Practice, 2022, 20(12): 2034-2037. doi: 10.16766/j.cnki.issn.1674-4152.002763
Citation: CHEN Nian-ping, HOU Hai-yan, QIU Yuan-li, SONG Cheng, ZHU Ya-fang, XU Liang. Application of nalbuphine combined with dexmedetomidine in painless ultrasound bronchoscopy[J]. Chinese Journal of General Practice, 2022, 20(12): 2034-2037. doi: 10.16766/j.cnki.issn.1674-4152.002763
shu

Application of nalbuphine combined with dexmedetomidine in painless ultrasound bronchoscopy

doi: 10.16766/j.cnki.issn.1674-4152.002763
  • 1.

    Department of Anesthesiology, Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang 312000, China

Funds:

 2020KY988

  • Received Date: 2021-11-25
    Available Online: 2023-02-07
    Abstract
  •   Objective  To investigate the influence of nalbuphine or sufentanil combined with dexmedetomidine on hemodynamics, respiratory rate and pain score in painless ultrasonic bronchoscopy.  Methods  Fifty patients planned to undergo painless ultrasound bronchoscopy in Affiliated Hospital of Shaoxing University from December 2019 to October 2021 were randomly divided into sufentanil combined with dexmedetomidine group (SD group) and nalbuphine combined with dexmedetomidine (ND group), 25 patients in each group. On the basis of topical anesthesia with lidocaine, the patients in the two groups were injected with dexmedetomidine 1 μg/kg (15 min) intravenously. The patients in the ND group were intravenously injected with nalbuphine 0.1 mg/kg and patients in the SD group were given sufentanil 0.1 μg/kg intravenously, then propofol was used to maintain anesthesia in both groups. The changes of blood pressure, heart rate, pulse oxygen saturation and respiratory rate were monitored before medication, at fibrobronchoscope entered glottis, biopsy and the end of examination. The amount of propofol, operation time, recovery time, anesthesia effect classification during the examination and the occurrence of adverse reactions after administration were observed and recorded. The VAS score before operation, 1 hour, 2 hours, 4 hours and 6 hours after operation were also evaluated and recorded.  Results  The changes in blood pressure, heart rate, pulse oxygen saturation and respiratory rate during bronchoscopy in the ND group were lower than those in the SD group (all P < 0.05). There was no significant difference in the dosage of propofol [(210.4±30.3) mg vs. (232.2±58.5) mg], operation time [(28.9±9.4) min vs. (30.1±8.8) min], recovery time [(8.3±2.2) min vs. (9.1±3.1) min] and excellent rate of anesthesia effect (96.0% vs. 72.0%) between the two groups (all P>0.05). The postoperative VAS score and the incidence of adverse reactions in the ND group were significantly lower than those in the SD group (all P < 0.05).  Conclusion  Nalbuphine combined with dexmedetomidine used in painless ultrasound bronchoscopy has stable hemodynamics and few adverse reactions. It is one of the safe and effective substitutes for sufentanil.

     

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