Volume 21 Issue 1
Jan.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 24-27
GAO Jing-jing, LI Cong, GAO Lei, BAO Peng, FEI Ai-hua, GAO Yan-hong. Changes in bone mineral density, bone metabolism and its influencing factors in early-onset type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2023, 21(1): 24-27. doi: 10.16766/j.cnki.issn.1674-4152.002803
Citation: GAO Jing-jing, LI Cong, GAO Lei, BAO Peng, FEI Ai-hua, GAO Yan-hong. Changes in bone mineral density, bone metabolism and its influencing factors in early-onset type 2 diabetes mellitus[J]. Chinese Journal of General Practice, 2023, 21(1): 24-27. doi: 10.16766/j.cnki.issn.1674-4152.002803
shu

Changes in bone mineral density, bone metabolism and its influencing factors in early-onset type 2 diabetes mellitus

doi: 10.16766/j.cnki.issn.1674-4152.002803
  • 1.

    Department of Geriatrics, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Funds:

 82071575

 20ZR1435100

  • Received Date: 2022-03-24
    Available Online: 2023-04-07
    Abstract
  •   Objective  To analyse the changes in bone mineral density, bone metabolism and its influencing factors in early-onset type 2 diabetes mellitus (T2DM).  Methods  We performed a retrospective analysis of 201 patients with T2DM who were diagnosed with diabetes aged ≤ 40 years old in the Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from January 2018 to December 2021. These subjects were classified as the early-onset group. In addition, we selected 107 non-diabetic patients matched with the early-onset group with regard to age and sex ratio as the control group. The general clinical data, biochemical indexes, mean bone mineral density (BMD) of lumbar spine L1-4 and bone metabolism markers were compared between the two groups.  Results  (1) After correcting the BMI, no statistically significant difference in BMD was observed between the early-onset group and control group (F=1.004, P>0.05). The levels of type Ⅰ procollagen amino-terminal peptide, osteocalcin, 25(OH)D3 and parathyroid hormone of the early-onset group were lower than those in the control group (t=3.941, 6.556, 7.123, 4.620, all P < 0.05), whereas no significant difference in β-carboxyl terminal peptide (β-CTX) was found between the two groups (t=1.684, P>0.05). (2) Correlation analysis results showed that BMD was independently and negatively correlated with age (95% CI: -0.007 to -0.001, P=0.012) but was independently and positively correlated with BMI (95% CI: 0.004 to 0.014, P=0.001) and HbA1c (95% CI: 0.002 to 0.021, P=0.014). β-CTX was independently and negatively correlated with age (95% CI: -0.013 to -0.003, P=0.001) and TC (95% CI: -0.079 to -0.015, P=0.004). In addition, the female gender was an independent risk factor for decreased β-CTX (95% CI: -0.177 to -0.020, P=0.014). P1NP was independently and negatively correlated with age (95% CI: -0.831 to -0.137, P=0.007), FPG (95% CI: -1.815 to -0.333, P=0.005) and TG (95% CI: -0.635 to -0.508, P=0.004).  Conclusion  There is no significant difference in BMD amongst patients with early-onset type 2 diabetes compared with non-diabetic people, but the markers of bone formation decrease. The age, gender, BMI, blood glucose and blood lipid levels are independent influencing factors of changes in BMD and bone metabolism in patients.

     

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    • References(20)
  • [1]
    管晶晶, 陈宇, 汤华冬, 等. 骨质疏松的健康管理发展现状及挑战[J]. 中华全科医学, 2021, 19(10): 1729-1732. doi: 10.16766/j.cnki.issn.1674-4152.002153

    GUAN JJ, CHEN Y, TANG HD, et al. Current status and challenges of health management for osteoporosis[J]. Chin J Gen Pract, 2021, 19(10): 1729-1732. doi: 10.16766/j.cnki.issn.1674-4152.002153
    [2]
    BARRETT T, JALALUDIN M Y, TURAN S, et al. Rapid progression of type 2 diabetes and related complications in children and young people: a literature review[J]. Pediatr Diabetes, 2020, 21(2): 158-172. doi: 10.1111/pedi.12953
    [3]
    LIN H H, HSU H Y, TSAI M C, et al. Association between type 2 diabetes and osteoporosis risk: a representative cohort study in Taiwan[J]. PLoS One, 2021, 16(7): e0254451. DOI: 10.1371/journal.pone.0254451.
    [4]
    刘杰, 顾天伟, 钟胜利, 等. 住院早发2型糖尿病患者代谢特征及慢性并发症情况[J]. 中华糖尿病杂志, 2020, 12(6): 387-392. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY202102020.htm

    LIU J, GU T W, ZHONG S L, et al. Metabolic profile and chronic complications in hospitalized patients with early onset type 2 diabetes mellitus[J]. Chin J Diabetes Mellitus, 2020, 12(6): 387-392. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYY202102020.htm
    [5]
    CHERUKURI L, KINNINGER A, BIRUDARAJU D, et al. Effect of body mass index on bone mineral density is age-specific[J]. Nutr Metab Cardiovasc Dis, 2021, 31(6): 1767-1773. doi: 10.1016/j.numecd.2021.02.027
    [6]
    RINONAPOLI G, PACE V, RUGGIERO C, et al. Obesity and bone: a complex relationship[J]. Int J Mol Sci, 2021, 22(24): 13662. doi: 10.3390/ijms222413662
    [7]
    宫祎慧, 闫彩凤. 肥胖患者脂肪分布和代谢与骨质疏松症关系的研究进展[J]. 中华肥胖与代谢病电子杂志, 2020, 6(1): 55-57. https://www.cnki.com.cn/Article/CJFDTOTAL-FPDX202001018.htm

    GONG Y H, YAN C F. Research progress on the relationship between fat distribution and metabolism in obese patients and osteoporosis[J]. Chin J Obes Metab Dis (Electronic Edition), 2020, 6(1): 55-57. https://www.cnki.com.cn/Article/CJFDTOTAL-FPDX202001018.htm
    [8]
    ZHAO H, ZHENG C, GAN K, et al. High body mass index and triglycerides help protect against osteoporosis in patients with type 2 diabetes mellitus[J]. J Diabetes Res, 2020, 2020: 1517879. DOI: 10.1155/2020/1517879.
    [9]
    GE B, LU S Q, LEI S F. The obesity indices mediate the relationships of blood lipids and bone mineral density in Chinese elders[J]. Mol Cell Probes, 2021, 56: 101705. DOI: 10.1016/j.mcp.2021.101705.
    [10]
    LI K H, LIU Y T, YANG Y W, et al. A positive correlation between blood glucose level and bone mineral density in Taiwan[J]. Arch Osteoporos, 2018, 13(1): 78. doi: 10.1007/s11657-018-0494-9
    [11]
    徐婉, 肖婧. 老年2型糖尿病患者血糖控制状况与合并骨质疏松症的相关性研究[J]. 中国糖尿病杂志, 2019, 27(10): 755-758. doi: 10.3969/j.issn.1006-6187.2019.10.008

    XU W, XIAO J. Correlation between the glucose control status and osteoporosis in elderly patients with type 2 diabetes mellitus[J]. Chin J Diabetes, 2019, 27(10): 755-758. doi: 10.3969/j.issn.1006-6187.2019.10.008
    [12]
    ZHAO H, QI C, ZHENG C, et al. Effects of glycated hemoglobin level on bone metabolism biomarkers in patients with type 2 diabetes mellitus[J]. Diabetes Metab Syndr Obes, 2020, 13: 1785-1791. doi: 10.2147/DMSO.S248844
    [13]
    FANG L, ZHONG S, MA D, et al. A cross-sectional study: an assessment of low muscle mass and osteoporosis in type 2 diabetes mellitus patients with a high glycated hemoglobin level[J]. Ther Adv Chronic Dis, 2021, 12: 20406223211026762. DOI: 10.1177/20406223211026762.
    [14]
    LIU X X, JIANG L, LIU Q, et al. Low bone turnover markers in young and middle-aged male patients with type 2 diabetes mellitus[J]. J Diabetes Res, 2020, 2020: 6191468. DOI: 10.1155/2020/6191468.
    [15]
    中华医学会骨质疏松和骨矿盐疾病分会. 骨转换生化标志物临床应用指南[J]. 中华骨质疏松和骨矿盐疾病杂志, 2021, 14(4): 321-336. doi: 10.3969/j.issn.1674-2591.2021.04.001

    China Society of Osteoporosis and Bone Mineral Research, China Medical Association. Guidelines for clinical application of bone turnover biomarkers[J]. Chin J Osteoporos Bone Miner Res, 2021, 14(4): 321-336. doi: 10.3969/j.issn.1674-2591.2021.04.001
    [16]
    HOLLOWAY-KEW K L, DE ABREU L L F, KOTOWICZ M A, et al. Bone turnover markers in men and women with impaired fasting glucose and diabetes[J]. Calcif Tissue Int, 2019, 104(6): 599-604. doi: 10.1007/s00223-019-00527-y
    [17]
    中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2017)[J]. 中华骨质疏松和骨矿盐疾病杂志, 2017, 10(5): 413-444. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZS201903001.htm

    China Society of Osteoporosis and Bone Mineral Research, China Medical Association. Guidelines for the diagnosis and treatment of primary osteoporosis (2017)[J]. Chin J Osteoporos Bone Miner Res, 2017, 10(5): 413-444. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZS201903001.htm
    [18]
    YAO X, XU X, JIN F, et al. The correlation of type 2 diabetes status with bone mineral density in middle-aged adults[J]. Diabetes Metab Syndr Obes, 2020, 13: 3269-3276.
    [19]
    JANG M, KIM H, LEA S, et al. Effect of duration of diabetes on bone mineral density: a population study on East Asian males[J]. BMC Endocr Disord, 2018, 18(1): 61.
    [20]
    CHENG C H, CHEN L R, CHEN K H. Osteoporosis due to hormone imbalance: an overview of the effects of estrogen deficiency and glucocorticoid overuse on bone turnover[J]. Int J Mol Sci, 2022, 23(3): 1376.
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