Volume 21 Issue 1
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(1): 81-83
LI Bin, QIU Li-ling, DU Kun, ZHAO Mei, GAO Jin, ZHAO Pei-li. Clinical features of neonatal severe enterovirus infection[J]. Chinese Journal of General Practice, 2023, 21(1): 81-83. doi: 10.16766/j.cnki.issn.1674-4152.002817
Citation: LI Bin, QIU Li-ling, DU Kun, ZHAO Mei, GAO Jin, ZHAO Pei-li. Clinical features of neonatal severe enterovirus infection[J]. Chinese Journal of General Practice, 2023, 21(1): 81-83. doi: 10.16766/j.cnki.issn.1674-4152.002817
shu

Clinical features of neonatal severe enterovirus infection

doi: 10.16766/j.cnki.issn.1674-4152.002817

  • Department of Neonatology, Kunming Children' s Hospital, Kunming Medical University, Kunming, Yunnan 650034, China

Funds:

 2020J0227

  • Received Date: 2022-01-04
    Available Online: 2023-04-07
    Abstract
  •   Objective  To analyze the clinical characteristics and influencing factors of neonatal severe enterovirus infection.  Methods  A retrospective analysis of neonatal enterovirus infection cases admitted to Children' s Hospital Affiliated of Kunming Medical University from December 2019 to December 2020 was performed. Based on the severity of infection, they were divided into the common infection group (n=63) and severe infection group (n=13). The clinical characteristics of the two groups were compared, and the risk factors of severe enterovirus infection were analysed by Logistic regression.  Results  Compared with the common infection group, the severe infection group had a significantly lower gestational age at birth and a significantly higher proportion of preterm infants and a significantly earlier onset time (P < 0.05). The abnormal white blood cells (< 5×109/L or >15×109/L), thrombocytopenia, pH decrease, C-reactive protein increase, procalcitonin and lactic acid increase were higher than those in the common infection group (all P < 0.05). The incidence of combined liver function abnormality, coagulation function abnormality and myocardial injury was also higher than that of common infection group (all P < 0.05). The mortality of children in severe infection group was higher than that in common infection group (P < 0.05). Multivariate logistic regression analysis showed that preterm birth (OR=7.125, 95% CI: 2.275-29.021), coagulation dysfunction (OR=22.452, 95% CI: 2.948-268.656) and pH ≤ 7.25 (OR=14.569, 95% CI: 2.675-40.590) were the risk factors for severe enterovirus infection.  Conclusion  Significant differences in clinical manifestations, complications and laboratory tests are observed between the neonates with common and severe enterovirus infection. Neonatal enterovirus infection is accompanied by premature delivery, early onset, acidosis, elevated lactic acid, abnormal liver function, and abnormal blood coagulation function, and it is necessary to be alert to severe infection.

     

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