Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 186-189
LIU Yao, WU Jin-huan, FAN Ming-xing, CHEN Jun, ZHAO Shao-dong, MIAO Hong-jun. Clinical study of dynamic monitoring of serum procalcitonin for anti-infection treatment in children with severe community acquired pneumonia[J]. Chinese Journal of General Practice, 2023, 21(2): 186-189. doi: 10.16766/j.cnki.issn.1674-4152.002841
Citation: LIU Yao, WU Jin-huan, FAN Ming-xing, CHEN Jun, ZHAO Shao-dong, MIAO Hong-jun. Clinical study of dynamic monitoring of serum procalcitonin for anti-infection treatment in children with severe community acquired pneumonia[J]. Chinese Journal of General Practice, 2023, 21(2): 186-189. doi: 10.16766/j.cnki.issn.1674-4152.002841
shu

Clinical study of dynamic monitoring of serum procalcitonin for anti-infection treatment in children with severe community acquired pneumonia

doi: 10.16766/j.cnki.issn.1674-4152.002841
  • 1.

    Department of Pharmacy, Children ' s Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China

Funds:

 BK20170147

 A202218

  • Received Date: 2022-11-21
    Available Online: 2023-04-20
    Abstract
  •   Objective  To explore the guiding significance and application value of dynamic monitoring of serum procalcitonin for anti-infection therapy in children with severe community acquired pneumonia.  Methods  A total of 150 children with severe community acquired pneumonia treated in Nanjing Children ' s Hospital from January 2019 to June 2022 were enrolled. They were assigned into observation group (65 cases) and control group (85 cases) according to whether dynamic procalcitonin monitoring was performed. The control group was treated with conventional antibacterial drugs, while the observation group was adjusted with the results of PCT dynamic monitoring. The use rate of antibiotics, the course of use, the cumulative consumption of antibiotics, the choice of drugs, the duration of fever, the time of ICU stay, and the outcome of discharge were compared between the two groups.  Results  The cumulative consumption of antibacterial drugs per capita in the control group was 3.50 (1.92, 6.20), while it was significantly lower than that in the observation group [2.13 (1.25, 4.95), P < 0.05]. The duration of antimicrobial treatment in the observation group was about 1 day shorter than that in the control group [7.0 (5.0, 10.0) days vs. 8.0 (5.0, 11.0) days, P < 0.05]. The total cost of antimicrobial drugs in the control group was 1 659.0 (1 036.3, 3 263.2) yuan, which was significantly higher than that in the observation group [762.2 (243.3, 1 423.8) yuan, P < 0.01]. The use rate of special grade antibiotics in the observation group was lower than that in the control group [27.3% (18/66) vs. 51.8% (44/85), P < 0.01]. There was no difference in the duration of fever, the time of ICU stay, the outcome of discharge between the two groups (P>0.05).  Conclusion  Dynamic monitoring of serum PCT is helpful to the rational use of antibiotics in children with severe community-acquired pneumonia, especially for the use, degradation and discontinuation of special grade antibiotics.

     

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