Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 203-206
PAN Li-na, XU Lei, MENG Nan-nan, CHENG Yu-ting. Effect of different proportions of enteral parenteral nutrition on patients with early-stage chronic obstructive pulmonary disease complicated with respiratory failure type Ⅱ[J]. Chinese Journal of General Practice, 2023, 21(2): 203-206. doi: 10.16766/j.cnki.issn.1674-4152.002845
Citation: PAN Li-na, XU Lei, MENG Nan-nan, CHENG Yu-ting. Effect of different proportions of enteral parenteral nutrition on patients with early-stage chronic obstructive pulmonary disease complicated with respiratory failure type Ⅱ[J]. Chinese Journal of General Practice, 2023, 21(2): 203-206. doi: 10.16766/j.cnki.issn.1674-4152.002845
shu

Effect of different proportions of enteral parenteral nutrition on patients with early-stage chronic obstructive pulmonary disease complicated with respiratory failure type Ⅱ

doi: 10.16766/j.cnki.issn.1674-4152.002845
  • 1.

    Department of Respiratory and Critical Care Medicine, the 10th People ' s Hospital of Tongji University, Shanghai 200072, China

Funds:

 2018LP043

  • Received Date: 2022-04-27
    Available Online: 2023-04-20
    Abstract
  •   Objective  To perform early enteral and parenteral nutrition with different calorie ratios in patients with chronic obstructive pulmonary disease (COPD) and type Ⅱ respiratory failure, and explore the impact of different proportions of early enteral and parenteral nutrition on the clinical treatment effect and prognosis of patients.  Methods  A total of 108 patients with COPD combined with type Ⅱ respiratory failure admitted to the 10th People ' s Hospital of Tongji University from February 2019 to February 2021 were selected and randomly divided into low, medium and high proportion groups, with 36 cases in each group according to random number table method. On the basis of conventional treatment, the three groups were given combined nutritional support with enteral and parenteral calorie ratios of 1∶ 3, 1∶ 1 and 3∶ 1. Respiratory function, nutritional status, gastrointestinal mucosal barrier function and clinical prognosis of the three groups were compared before and after treatment.  Results  After 10 days of treatment, respiratory function, nutritional status and gastrointestinal mucosal barrier function-related indices in the three groups were significantly improved compared with before treatment (all P < 0.05). PaO2, FVC, FEV1/FVC, ALB, PA and TRF in high-proportion groups were significantly higher than those in the medium-and low-proportion groups (all P < 0.05). D-lactic acid, DAO and procalcitonin were significantly lower than those in the medium-and low-proportion groups (all P < 0.05). PaCO2 in the high-proportion group was significantly lower than that in the low-proportion group (P < 0.05), and ALB, PA and TRF in the medium-proportion group were significantly higher than those in the low-proportion group (all P < 0.05). The mechanical ventilation duration, length of ICU stay and total length of hospital stay in the high-proportion group were significantly lower than those in the low-proportion group (all P < 0.05). The 28-day mortality was not significantly different among the three groups (13.8%, 8.33%, 3.56%, χ2=1.543; P=0.462).  Conclusion  Early enteral parenteral combined nutrition can effectively improve the respiratory function, nutritional status and intestinal mucosal barrier dysfunction in patients with COPD and respiratory failure type Ⅱ, as well as the prognosis. The combined nutrition program with enteral parenteral nutrition calorie ratio of 3∶ 1 has the best effect.

     

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    • References(16)
  • [1]
    刘颖, 杨志高, 李慧琼, 等. 肠内联合肠外营养与肠内营养支持治疗COPD机械通气患者疗效比较的Meta分析[J]. 医学信息, 2022, 35(10): 98-104. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXX202210024.htm

    LIU Y, YANG Z G, LI H Q, et al. Meta-analysis of the efficacy of enteral combined parenteral nutrition and enteral nutrition support in the treatment of COPD patients with mechanical ventilation[J]. Journal of Medical Information, 2022, 35(10): 98-104. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXX202210024.htm
    [2]
    GAYAN-R G. Relevance of nutritional support and early rehabilitation in hospitalized patients with COPD[J]. Thorac Dis, 2018, 10(Suppl 12): 1400-1414.
    [3]
    赵凤娥. 肠外营养联合肠内营养对老年肺癌术后化疗患者营养状况及免疫功能的影响分析[J]. 河南外科学杂志, 2021, 27(5): 142-143. https://www.cnki.com.cn/Article/CJFDTOTAL-HLWK202105063.htm

    ZHAO F E. Effect of parenteral nutrition combined with enteral nutrition on nutritional status and immune function in elderly patients with postoperative chemotherapy for lung cancer[J]. Henan Journal of Surgery, 2021, 27(5): 142-143. https://www.cnki.com.cn/Article/CJFDTOTAL-HLWK202105063.htm
    [4]
    马艳梅, 常箫匀. 结直肠癌患者围手术期肠内外联合营养支持与预后的关系[J]. 中国医科大学学报, 2018, 47(7): 604-608. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYK201807008.htm

    MA Y M, CHANG X Y. Relationship between perioperative enteral nutrition and prognosis in patients with colorectal cancer[J]. Journal of China Medical University, 2018, 47(7): 604-608. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYK201807008.htm
    [5]
    王丽丽, 王晓林. 等热卡不同蛋白质含量肠内营养对COPD并发重症肺部感染患者代谢的影响[J]. 医药论坛杂志, 2021, 42(21): 98-101. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202121026.htm

    WANG L L, WANG X L. Effects of different protein content of isocarb on metabolism of patients with COPD complicated with severe pulmonary infection[J]. Journal of Medical Forum, 2021, 42(21): 98-101. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202121026.htm
    [6]
    严飞飞, 徐旭东, 张海波, 等. 健脾通络汤治疗慢性阻塞性肺疾病合并抑郁症的效果研究[J]. 中华全科医学, 2022, 20(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.002560

    YAN F F, XU X D, ZHANG H B, et al. Effects of Jianpi Tongluo Decoction on chronic obstructive pulmonary disease complicated with depression[J]. Chinese Journal of General Practice, 2022, 20(7): 1211-1214. doi: 10.16766/j.cnki.issn.1674-4152.002560
    [7]
    徐超, 卞月梅, 李成恩, 等. 肠内营养时机对慢性阻塞性肺疾病急性加重期机械通气患者疗效和预后的影响[J]. 中国现代医生, 2020, 58(11): 88-91. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202011029.htm

    XU C, BIAN Y M, LI C E, et al. Effect of enteral nutrition timing on the efficacy and prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease undergoing mechanical ventilation[J]. China Modern Doctor, 2020, 58(11): 88-91. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDYS202011029.htm
    [8]
    赵雨, 杨雪钰. 序贯肠内外营养支持对慢性阻塞性肺疾病急性加重期合并呼吸衰竭患者的影响[J]. 实用临床医药杂志, 2021, 25(1): 41-44. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202101011.htm

    ZHAO Y, YANG X Y. Effect of sequential enteral and parenteral nutrition for patients with acute exacerbation of chronic obstructive pulmonary disease complicated with respiratory failure[J]. Journal of Clinical Medicine in Practice, 2021, 25(1): 41-44. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202101011.htm
    [9]
    OLIVEIRA B A D S, PONTES E R J C, ROSA T C A. Resolution of control and monitoring instrument of nutritional therapy in the intensive care unit of a university hospital[J]. Nutr Hosp, 2018, 35(1): 19-24.
    [10]
    CHAO P C, LIN C F, CHUANG H J, et al. Parenteral nutrition combined with enteral feeding improves the outcome of cancer patients[J]. Asia Pac J Clin Nutr, 2017, 26 (6): 1032.
    [11]
    杨翠, 赵亚光, 靳杨, 等. 早期肠内营养联合经鼻高流量氧疗对慢性阻塞性肺疾病合并急性中度Ⅱ型呼吸衰竭的临床疗效分析[J]. 中国医学前沿杂志(电子版), 2019, 11(7): 167-171. https://www.cnki.com.cn/Article/CJFDTOTAL-YXQY201907023.htm

    YANG C, ZHAO Y G, JIN Y, et al. Effect of early enteral nutrition combined with high-flow nasal cannula on chronic obstructive pulmonary disease complicated with acute-moderate type Ⅱ respiratory failure[J]. Chinese Journal of the Frontiers of Medical Science(Electronic Version), 2019, 11(7): 167-171. https://www.cnki.com.cn/Article/CJFDTOTAL-YXQY201907023.htm
    [12]
    魏军, 于春妮, 牛小娜. 早期肠内肠外联合营养的不同比例对慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者的应用效果分析[J]. 中国医学前沿杂志(电子版), 2020, 12(12): 115-120. https://www.cnki.com.cn/Article/CJFDTOTAL-YXQY202012026.htm

    WEI J, YU C N, NIU X N. Effect of different proportion of early enteral and parenteral nutrition on patients with chronic obstructive pulmonary disease combined with typeⅡrespiratory failure[J]. Chinese Journal of the Frontiers of Medical Science(Electronic Version), 2020, 12(12): 115-120. https://www.cnki.com.cn/Article/CJFDTOTAL-YXQY202012026.htm
    [13]
    何玥. 肠内营养及综合护理干预对慢性阻塞性肺疾病患者营养状况、肺功能及生活质量的影响[J]. 中国疗养医学, 2018, 27(2): 180-182. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGLX201802031.htm

    HE Y. Effects of enteral nutrition and comprehensive nursing intervention on nutritional status, lung function and quality of life in patients with chronic obstructive pulmonary disease[J]. Chinese Journal of Convalescent Medicine, 2018, 27(2): 180-182. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGLX201802031.htm
    [14]
    谌步云, 吴杏梅, 张鸿光, 等. 早期肠内-肠外联合营养对老年结直肠癌患者术后营养状况及免疫功能的影响[J]. 浙江医学, 2019, 41(2): 150-153. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE201902015.htm

    CHEN B Y, WU X M, ZHANG H G, et al. Impact of early enteral combined with parenteral nutrition on postoperative nutritional status and immune function in elderly patients with colorectal cancer[J]. Zhejiang Medical Journal, 2019, 41(2): 150-153. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE201902015.htm
    [15]
    杨军, 周涛, 付加强, 等. 急性胰腺炎的肠内营养: 从"胰腺休息"到"肠道唤醒"[J]. 转化医学电子杂志, 2018, 5(4): 58-62. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHDZ201804014.htm

    YANG J, ZHOU T, FU J Q, et al. The transformation of enteral nutrition therapy in acute pancreatitis[J]. E-Journal of Translational Medicine, 2018, 5(4): 58-62. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHDZ201804014.htm
    [16]
    李青, 史琳娜, 杨顺玉, 等. 不同比例肠内营养支持对重型颅脑损伤病人临床结局的影响[J]. 肠外与肠内营养, 2018, 25(3): 161-165. https://www.cnki.com.cn/Article/CJFDTOTAL-CWCN201803013.htm

    LI Q, SHI L N, YANG S Y, et al. Effect of percentage of enteral nutrition in the total energy and nutrition support for patients with traumatic brain injury[J]. Parenteral & Enteral Nutrition, 2018, 25(3): 161-165. https://www.cnki.com.cn/Article/CJFDTOTAL-CWCN201803013.htm
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