Volume 21 Issue 2
Feb.  2023
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ZHU Cai-xia, TIAN Dou-dou, YU Yun-xia, ZHANG Ke-dong. Expression of KL-6 in patients with rheumatoid arthritis-associated interstitial lung disease[J]. Chinese Journal of General Practice, 2023, 21(2): 247-249. doi: 10.16766/j.cnki.issn.1674-4152.002856
Citation: ZHU Cai-xia, TIAN Dou-dou, YU Yun-xia, ZHANG Ke-dong. Expression of KL-6 in patients with rheumatoid arthritis-associated interstitial lung disease[J]. Chinese Journal of General Practice, 2023, 21(2): 247-249. doi: 10.16766/j.cnki.issn.1674-4152.002856
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Expression of KL-6 in patients with rheumatoid arthritis-associated interstitial lung disease

doi: 10.16766/j.cnki.issn.1674-4152.002856

  • Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, China

Funds:

 XZ2018005

 2019BEG03021

  • Received Date: 2022-02-22
    Available Online: 2023-04-20
    Abstract
  •   Objective  Krebs von den Lungen-6 (KL-6) is mainly expressed in type Ⅱ alveolar epithelium and bronchial epithelial cells, and increased in lung infection, interstitial lung disease. This study plans to investigate the expression of KL-6 in rheumatoid arthritis-related interstitial lung diseases.  Methods  Sixty-eight patients with rheumatoid arthritis (RA) who were diagnosed for the first time and treated in the General Hospital of Ningxia Medical University from January 2018 to December 2020 were collected, including 35 patients with RA without pulmonary interstitial lesions confirmed by chest CT (RA group) and 33 patients with RA with interstitial lung disease (RA-ILD group). Another 30 healthy people at the same time were enrolled. Serum of three groups of patients and joint effusion of some patients in RA group and RA-ILD group were collected respectively, and the expression level of KL-6 was detected by ELISA. The clinical characteristics such as gender, age and course of disease of patients in RA group and RA-ILD group were analyzed. The expression level of KL-6 in serum of patients with chronic obstructive pulmonary disease (COPD) and without COPD in RA group was analyzed.  Results  There was no significant difference in gender and age between RA group and RA-ILD group. The course of disease in the RA-ILD group was significantly longer than that in the RA group [(163.50±88.07) months vs. (94.42±50.14) months, P < 0.05]. In RA group, there were 6 patients with COPD, and there was no significant difference in serum KL-6 level compared with patients without COPD in the same group. The expression level of serum KL-6 in RA-ILD group was (100.96±14.29) U/mL, which were significantly higher than that in RA group [(30.33±5.30) U/mL] and normal control group [(26.67±2.78) U/mL], but there was no significant difference between RA group and normal control group. The level of KL-6 in joint cavity effusion of RA patients was significantly lower than that of RA-ILD patients (P < 0.05).  Conclusion  The expression of KL-6 is increased in RA-ILD patients, and KL-6 is an effective index to reflect the severity of pulmonary interstitial lesions in RA-ILD patients.

     

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