Volume 21 Issue 2
Feb.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 255-258
REN Fei, WEI Teng-fei, TU Sheng. Hyperuricemia predicts adverse outcomes ater myocardial infarction with non-obstructive coronary arteries[J]. Chinese Journal of General Practice, 2023, 21(2): 255-258. doi: 10.16766/j.cnki.issn.1674-4152.002858
Citation: REN Fei, WEI Teng-fei, TU Sheng. Hyperuricemia predicts adverse outcomes ater myocardial infarction with non-obstructive coronary arteries[J]. Chinese Journal of General Practice, 2023, 21(2): 255-258. doi: 10.16766/j.cnki.issn.1674-4152.002858
shu

Hyperuricemia predicts adverse outcomes ater myocardial infarction with non-obstructive coronary arteries

doi: 10.16766/j.cnki.issn.1674-4152.002858

  • Department of Cardiovascular Medicine, the People's Hospital of Bozhou, Bozhou, Anhui 236800, China

Funds:

 KJ2020A0336

  • Received Date: 2022-04-18
    Available Online: 2023-04-20
    Abstract
  •   Objective  This study aimed to investigate the potential association between hyperuricemia and the adverse outcomes in myocardial infarction with non-obstructive coronary arteries (MINOCA) patients.  Methods  A total of 168 patients diagnosed with acute myocardial infarction who underwent emergency coronary angiography and were diagnosed as MINOCA in the Department of Cardiology of the People's Hospital of Bozhou from January 2019 to June 2020 were enrolled, and were divided into two groups based on the level of serum creatinine: hyperuricemia group (47 cases) and normouricemia group (121 cases). Follow-up was carried out for 18 months after discharge through outpatient visits, telephone calls, reviewing electronic medical records and clinical notes by two experienced cardiologists to obtain patient's clinical status and major adverse cardiovascular and cerebrovascular events (MACCE) or the first reported outcome case. The study also aimed to explore the association between hyperuricemia and adverse outcomes in MINOCA patients.  Results  All patients had follow-up data, of which 35 MACCE were recorded. The hyperuricemia group was associated with 16 MACCE, whereas 19 MACCE occurred in the normouricemia group. The hyperuricemia group had a higher incidence of MACCE and nonfatal myocardial infarction (MI) compared with the normouricemia group (34.0% vs. 15.7% and 10.6% vs. 0.8%, respectively; both P < 0.05). The increased risk of MACCE in the hyperuricemia group is shown in Kaplan-Meier survival curves, which demonstrated that MINOCA patients within the hyperuricemia group were clearly different from those in the normouricemia group, and this difference is statistically significant (log-rank P=0.003).  Conclusion  Hyperuricemia is associated with adverse outcomes and appears to be an independent predictor of MACCE in MINOCA patients. This finding indicates that the serum uric acid levels may serve as a surrogate biomarker related to risk prediction and adverse outcomes of MINOCA patients.

     

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