Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 598-601
JIANG Ni, ZHOU Baotong, FAN Hongwei, MIAO Qi, LIU Xiaoqing, LI Taisheng. Clinical Analysis of 29 cases of Staphylococcus aureus endocarditis[J]. Chinese Journal of General Practice, 2023, 21(4): 598-601. doi: 10.16766/j.cnki.issn.1674-4152.002939
Citation: JIANG Ni, ZHOU Baotong, FAN Hongwei, MIAO Qi, LIU Xiaoqing, LI Taisheng. Clinical Analysis of 29 cases of Staphylococcus aureus endocarditis[J]. Chinese Journal of General Practice, 2023, 21(4): 598-601. doi: 10.16766/j.cnki.issn.1674-4152.002939
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Clinical Analysis of 29 cases of Staphylococcus aureus endocarditis

doi: 10.16766/j.cnki.issn.1674-4152.002939
  • 1.

    Department of Infectious Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100027, China

Funds:

 GSWSKY2017-45

 20JR5RA364

  • Received Date: 2022-03-09
    Available Online: 2023-05-31
    Abstract
  •   Objective  To analyze the clinical characteristics of Staphylococcus aureus (SA) endocarditis, in order to improve the clinical treatment of this disease.  Methods  Patients with SA endocarditis hospitalized in Peking Union Medical College Hospital from January 2012 to January 2022 were retrospectively analyzed. The epidemiological characteristics, clinical characteristics, laboratory and imaging findings, therapeutic measures and prognosis were analyzed.  Results  A total of 29 patients with SA endocarditis were included. Among them, 16 were males and 13 were females, aged from 17 to 82 years. Among these patients, methicillin sensitive Staphylococcus aureus was found in 16 cases (MSSA group) and methicillin resistant Staphylococcus aureus was found in 13 cases (MRSA group). Seven (24.14%) had congenital heart disease, 19 (65.52%) had underlying chronic diseases, and 4 (13.79%) had a history of previous cardiac surgery. Half of the patients had skin barrier damage in the early stage, all patients had fever during the course of the disease, 18 (62.07%) patients had heart souffle, 22 (75.86%) patients had migration lesions, and most of these were suppurative pericarditis and lung abscess, which were more likely to occur in MSSA group. The positive time of MSSA culture was 14.0 (9.3, 25.5) h in aerobic bottle and 16.0 (10.3, 37.5) h in anaerobic bottle. The positive time of MSSA culture was less than that of MRSA group (Z=-2.289, P=0.022). There were 13 patients with cardiac valve grafts larger than 10 mm, and the grafts were most often attached to the aortic valve with a total of 11 cases (37.93%). The most commonly used antibiotics were vancomycin and daptomycin, and 19 cases (65.52%) received surgical treatment. In the end, the condition of 21 (72.41%) patients improved and 8 (27.59%) got worse.  Conclusion  In high-risk groups with SA infection and long-term fever, careful cardiac auscultation should be carried out, and blood culture and cardiac ultrasound should be completed as soon as possible. Once confirmed, timely antibacterial treatment and timely surgical operation may improve the prognosis.

     

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