Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 622-625
SHU Zhongyu, DENG Fang, YANG Shuxinying. Analysis of the influencing factors of Kawasaki disease combined with liver function impairment[J]. Chinese Journal of General Practice, 2023, 21(4): 622-625. doi: 10.16766/j.cnki.issn.1674-4152.002945
Citation: SHU Zhongyu, DENG Fang, YANG Shuxinying. Analysis of the influencing factors of Kawasaki disease combined with liver function impairment[J]. Chinese Journal of General Practice, 2023, 21(4): 622-625. doi: 10.16766/j.cnki.issn.1674-4152.002945
shu

Analysis of the influencing factors of Kawasaki disease combined with liver function impairment

doi: 10.16766/j.cnki.issn.1674-4152.002945
  • 1.

    Internal Medicine, Anhui Hospital, Pediatric Hospital Affiliated to Fudan University, Hefei, Anhui 230051, China

Funds:

 202004j07020028

  • Received Date: 2022-03-28
    Available Online: 2023-05-31
    Abstract
  •   Objective  This study aims to analyze the clinical features of Kawasaki disease (KD) with liver function impairment, and to explore the possible influencing factors of it.  Methods  The clinical data of 300 children with KD in Anhui Pediatric Hospital of Fudan University, ranging from January 2020 to December 2020, were collected. According to the presence or absence of liver function impairment, the children were divided into normal liver function group [181 cases (60.3%)] and abnormal liver function group [119 cases (39.7%)].The age, gender, total serum bilirubin (TBIL), serum albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), erythrocyte sedimentation rate (ESR), calcitoninogen (PCT), total white blood cell count (WBC), platelet count (PLT), C-reactive protein (CRP) of the children in the 2 groups were compared, PLT, PCT and CRP were included in the binary logistic regression analysis.  Results  Of the 300 children with KD, 189 (63.0%) were male and 111 (37.0%) were female, and the male-to-female ratio was 1.7∶ 1; The minimum age was 2 months, and the maximum age was 9 years, with a median age of 2 years; There were 45 cases (37.8%) under 1 years old, 54 cases (45.4%) were 2-3 years old, 12 cases (10.1%) were 4-5 years old, and 8 cases more than 6 years old (6.7%) in the group with abnormal liver function. Some children showed mild gastrointestinal symptoms. There were 8 children with vomiting (2.7%), 6 with diarrhea (2.0%), 2 with abdominal pain (0.7%) and 1 with hepatomegaly (0.3%). Compared the general data such as age and gender, the differences were not statistically significant (all P>0.05); ALT, AST, ALB, GGT, TBIL, PLT, PCT, CRP were significantly higher in the group with abnormal liver function than in the group with normal liver function, the differences were statistically significant (all P < 0.05). PLT, PCT and CRP were included in the binary logistic regression analysis. The results showed that PLT, PCT and CRP were all influencing factors of abnormal liver function in children with KD (all P < 0.05).  Conclusion  Increased PLT, PCT and CRP are risk factors for KD combined with liver function impairment.

     

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