Volume 21 Issue 4
Apr.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 650-654
FENG Hongyan, TU Ning, WANG Ke, XIAO Xiong, WANG Chao, BU Lihong. Value of PET/CT on diagnosis and staging of primary bone lymphoma[J]. Chinese Journal of General Practice, 2023, 21(4): 650-654. doi: 10.16766/j.cnki.issn.1674-4152.002952
Citation: FENG Hongyan, TU Ning, WANG Ke, XIAO Xiong, WANG Chao, BU Lihong. Value of PET/CT on diagnosis and staging of primary bone lymphoma[J]. Chinese Journal of General Practice, 2023, 21(4): 650-654. doi: 10.16766/j.cnki.issn.1674-4152.002952
shu

Value of PET/CT on diagnosis and staging of primary bone lymphoma

doi: 10.16766/j.cnki.issn.1674-4152.002952

  • PET Center, Molecular Imaging Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Funds:

 81701735

  • Received Date: 2022-11-30
    Available Online: 2023-05-31
    Abstract
  •   Objective  Primary bone lymphoma (PBL) is a rare type of malignant lymphoma. This study mainly analyzes the 18F-FDG PET/CT imaging signs of PBL in order to improve the accuracy of the diagnosis and differential diagnosis of PBL, and conduct accurate staging to guide accurate clinical treatment.  Methods  A total of 10 patients with untreated PBL were retrospectively enrolled from March 2018 to October 2020 in PET Center of People ' s Hospital of Wuhan University. We analyzed the PET/CT, MRI characteristic and clinical data of PBL patients. There were 7 males and 3 females. The range of age was 29-73 years old with the median age of 46.0±7.4. Ten patients underwent PET/CT examination and 8 patients underwent MRI scanning. Using bone biopsy results as gold standard, the sites of bone infiltration and the detection rates of the PET/CT and MRI were analyzed.  Results  The main clinical symptoms of PBL patients were bone pain at different locations. The types of pathology of patients all were non-Hodgkin ' s lymphoma, and diffuse large B cell lymphoma in 5 patients. The 18F-FDG PET/CT were high uptake in all of patients with SUVmax 2.7-17.5 (10.2±5.2). Multiple involved lesions were found in 8 patients, while 2 patients presented with a single involved lesion. Four patients were found to be located in extremity skeleton, 2 in the axial skeleton and 4 in the extremity skeleton and axial skeleton. PET/CT also found the lesions infiltrate to the surrounding soft tissue in 6 patients. MRI images lack specificity, the focus showed iso-intensity or low signal on T1WI and slightly high or high signal on T2WI, and enhanced scan showed moderate enhancement. The detection rate of the PET/CT and MRI for PBL were 94.5% and 89.1%, respectively.  Conclusion  18F-FDG PET/CT has the ability to depict bone lesions, and upper draining lymph nodes and extra-nodal involvement. It has good clinical application value for diagnosis and staging of PBL.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    SHEN G, SU M, LIU B, et al. PET/CT Imaging for solitary primary bone lymphoma of thoracic vertebra[J]. Clin Nucl Med, 2018, 43(11): 857-859. doi: 10.1097/RLU.0000000000002275
    [2]
    WANG L J, WU H B, WANG M, et al. Utility of F-18 FDG PET/CT on the evaluation of primary bone lymphoma[J]. Eur J Radiol, 2015, 84(11): 2275-2279. doi: 10.1016/j.ejrad.2015.09.011
    [3]
    HUAN Y, QI Y, ZHANG W, et al. Primary bone lymphoma of radius and tibia: a case report and review of literature[J]. Medicine (Baltimore), 2017, 96(15): e6603. DOI: 10.1097/MD.0000000000006603.
    [4]
    BARZ M, AFTAHY K, JANSSEN I, et al. Spinal manifestation of malignant primary (PLB) and secondary bone lymphoma (SLB)[J]. Curr Oncol, 2021, 28(5): 3891-3899. doi: 10.3390/curroncol28050332
    [5]
    沈小东, 王喜, 钱申贤. 18F-FDGPET-CT在自体高效CIK细胞联合化疗治疗初诊弥漫大B细胞淋巴瘤中的应用[J]. 中华全科医学, 2018, 16(6): 892-895. doi: 10.16766/j.cnki.issn.1674-4152.000244

    SHEN X D, WANG X, QIAN S X. Application of 18F-FDG, PET-CT, and CIK in the treatment of diffuse large cell lymphoma in patients with newly diagnosed diffuse large B cell lymphoma[J]. Chinese Journal of General Practice, 2018, 16(6): 892-895. doi: 10.16766/j.cnki.issn.1674-4152.000244
    [6]
    王友群, 唐小万. CHOP方案联合美罗华治疗弥漫大B细胞淋巴瘤78例回顾性分析[J]. 中华全科医学, 2018, 16(6): 916-918. doi: 10.16766/j.cnki.issn.1674-4152.000251

    WANG Y Q, TANG X W. A retrospective analysis of 78 cases of diffuse large B-cell lymphoma treated with CHOP chemotherapy regimen combined with rituximab[J]Chinese Journal of General Practice, 2018, 16(6): 916-918. doi: 10.16766/j.cnki.issn.1674-4152.000251
    [7]
    JADIDI J, BEHZADI F, SIGHARY M et al. Primary bone lymphoma of patella: a case report and review of literature[J]. Radiol Case Rep, 2019, 14(12): 1561-1565. doi: 10.1016/j.radcr.2019.09.015
    [8]
    于荭, 赵建, 于宝海, 等. 不同部位骨原发性非霍奇金淋巴瘤的影像表现对比分析[J]. 放射学实践, 2021, 36(1): 33-36. https://www.cnki.com.cn/Article/CJFDTOTAL-FSXS202101013.htm

    YU H, ZHAO J, YU B H, et al. Comparative analysis of imaging findings of primary non-Hodgkin lymphoma of bone in different locations[J]. Radiological Practice, 2021, 36(1): 33-36. https://www.cnki.com.cn/Article/CJFDTOTAL-FSXS202101013.htm
    [9]
    姚卓, 綦向. 原发性骨淋巴瘤的MRI及CT表现分析[J]. 中国CT和MRI杂志, 2020, 18(12): 148-151. https://www.cnki.com.cn/Article/CJFDTOTAL-CTMR202012047.htm

    YAO Z, QI X. CT, MRI features and pathological analysis of primary lymphoma of bone[J]. Chinese Journal of CT and MRI, 2020, 18(12): 148-151. https://www.cnki.com.cn/Article/CJFDTOTAL-CTMR202012047.htm
    [10]
    于宝海, 刘杰, 钟志伟, 等. 骨原发性淋巴瘤影像分析[J]. 中华放射学杂志, 2011, 45(7): 653-656. https://www.cnki.com.cn/Article/CJFDTOTAL-LYYX202007022.htm

    YU B H, LIU J, ZHONG Z W, et al. Analysis of image findings in forty-one patients with primary lymphoma of the bone[J]. Chin J Radiol, 2011, 45(7): 653-656. https://www.cnki.com.cn/Article/CJFDTOTAL-LYYX202007022.htm
    [11]
    郑敏, 张晓宝, 林晨琳, 等. 骨原发淋巴瘤的多模态影像学分析[J]. 功能与分子医学影像学(电子版), 2018, 10(4): 1553-1558.

    ZHEN M, ZHANG X B, LIN C L, et al. Multimodality imaging analysis of primary lymphoma of bone[J]. Funct Mol Med Imaging (Electronic Edition), 2018, 10(4): 1553-1558.
    [12]
    CARROLL G, BREIDAHL W, ROBBINS P, et al. Musculoskeletal lymphoma: MRI of bone or soft tissue presentations[J]. J Med Imaging Radiat Oncol, 2013, 57(6): 663-673. http://www.nstl.gov.cn/paper_detail.html?id=42295fd08c7990437b61d43334bc5c0a
    [13]
    BALBO-WUSSETTO A, SAVIOLO C, FORNARI A, et al. Whole body MRI with qualitative and quantitative analysis of DWI for assessment of bone marrow involvement in lymphoma[J]. Radiol Med, 2017, 122(8): 623-632. http://www.onacademic.com/detail/journal_1000039884904510_6f67.html
    [14]
    LIU Y Y. The role of 18F-FDG PET/CT in staging and restaging primary bone lymphoma[J]. Nucl Med Commun, 2017, 38(4): 319-324. http://www.onacademic.com/detail/journal_1000040028192110_5fd6.html
    [15]
    CHISHOLM K M, OHGAMI R S, TAN B, et al. Primary lymphoma of bone in the pediatric and young adult population[J]. Hum Pathol, 2017, 60: 1-10. http://www.onacademic.com/detail/journal_1000039517460710_0bc0.html
    [16]
    BARZ M, AFTAHY K, JANSSEN I, et al. Spinal manifestation of malignant primary (PLB) and Secondary Bone Lymphoma (SLB)[J]. Curr Oncol, 2021, 28(5): 3891-3899. http://pubmed.ncbi.nlm.nih.gov/34677250/
    [17]
    SHYAMASUNDAR L G, KANDAGADDALA M, JENNIFER A, et al. A rare presentation of primary lymphoma of bone with aneurysmal bone cyst-like changes[J]. Skeletal Radiol, 2021, 50(5): 1029-1037. doi: 10.1007/s00256-020-03641-3
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (276) PDF downloads(11) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return