Effect of <i>Jieyu Qingxin Anshen</i> Decoction on adverse emotion and quality of life scale score in patients with depression

WANG Jiangang; YAN Huanni; ZHANG Ke; LIU Panmiao

doi:10.16766/j.cnki.issn.1674-4152.002959

Volume 21 Issue 4

Apr. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(4): 681-684

WANG Jiangang, YAN Huanni, ZHANG Ke, LIU Panmiao. Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression[J]. Chinese Journal of General Practice, 2023, 21(4): 681-684. doi: 10.16766/j.cnki.issn.1674-4152.002959

Citation:

WANG Jiangang, YAN Huanni, ZHANG Ke, LIU Panmiao. Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression[J]. Chinese Journal of General Practice, 2023, 21(4): 681-684. doi: 10.16766/j.cnki.issn.1674-4152.002959

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Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.002959

1.
Department of Psychiatry, the Sixth People' s Hospital, Zhoukou, Henan 466000, China

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LHGJ20200295

Received Date: 2022-06-01
Available Online: 2023-05-31

Abstract

Abstract

Objective To explore the effect of Jieyu Qingxin Anshen Decoction in the treatment of depression and its effect on the generation of adverse emotion and the score of quality of life scale (QOL). Methods A total of 120 patients with depression collected in the Psychiatric Department of the Sixth People ' s Hospital of Zhoukou City, Henan Province from October 2019 to October 2021 were divided into regular group and study group according to the random number table method, with 60 cases in each group. The patients in the regular group were treated with venlafaxine hydrochloride sustained-release tablets, and the patients in the study group were treated with Jieyu Qingxin Anshen Decoction on the basis of the regular group. After 2 months of treatment, the clinical efficacy, the level of regulating hormone of thalamus adrenal pituitary axis (HPA) axis, brain-derived neurotrophic factor (BDNF), serum high-sensitivity C-reactive protein (hs-CRP) and uric acid (UA), adverse emotion, quality of life and adverse reactions were compared between the two groups. Results Compared with the regular group, the total effective rate (91.67% vs. 78.33%) in the study group was significantly higher, while the incidence of adverse reactions (3.33% vs. 13.33%) and adverse reaction symptoms scale (TESS) score [(2.57±1.42) points vs. (4.78±1.47) points] were significantly lower (all P < 0.05). Compared with before treatment, the levels of serum cortisol (COR), adrenocortical hormones (ACTH), hs-CRP, 17-item Hamilton depression scale (HAMD-17) score and Hamilton anxiety scale (HAMA) score in the two groups decreased significantly after treatment, while the levels of serum BDNF, UA and QOL score increased significantly (all P < 0.05), and the change range of the above indexes in the study group were significantly greater than that in the regular group (all P < 0.05). Conclusion Jieyu Qingxin Anshen Decoction can improve the adverse emotion and quality of life of patients with depression, with significant therapeutic effect and high safety.
- Depression,
- Jieyu Qingxin Anshen Decoction,
- Adverse emotion,
- Quality of life score

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References(23)

References

[1]	薛亮, 朱明, 吴明飞. 奥沙西泮联合阿米替林治疗抑郁症的临床研究[J]. 现代药物与临床, 2022, 37(4): 770-773. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202204015.htm XUE L, ZHU M, WU M F. Clinical study of oxazepam combined with amitriptyline in treatment of depression[J]. Drugs & Clinic, 2022, 37(4): 770-773. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202204015.htm
[2]	韩庆林, 芦文娟, 李书迪. 疏利少阳方治疗难治性抑郁症的疗效[J]. 实用临床医药杂志, 2021, 25(11): 63-67. doi: 10.7619/jcmp.20210735 HAN Q L, LU W J, LI S D. Therapeutic effect of Shuli Shaoyang Prescription for refractory depression[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 63-67. doi: 10.7619/jcmp.20210735
[3]	闫晓如, 卫佳宁, 王丽, 等. 实验动物在抑郁症研究中的应用[J]. 中国药物与临床, 2020, 20(15): 2540-2542. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202015027.htm YAN X R, WEI J N, WANG L, et al. Application of experimental animals in depression research[J]. Chinese Remedies & Clinics, 2020, 20(15): 2540-2542. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202015027.htm
[4]	徐莉, 吴云, 夏乐宏. 疏肝解郁安神汤治疗抑郁症临床研究及对睡眠质量、神经递质的影响[J]. 新中医, 2021, 53(4): 69-72. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202104020.htm XU L, WU Y, XIA L H. Clinical Study on Shugan Jieyu Anshen Tang for Depression and Its Effect on Sleep Quality and Neurotransmitter[J]. Journal of New Chinese Medicine, 2021, 53(4): 69-72. https://www.cnki.com.cn/Article/CJFDTOTAL-REND202104020.htm
[5]	和丽杰, 徐启春. 解郁清心安神汤治疗抑郁症肝郁化火、扰心伤神证疗效观察[J]. 中西医结合心血管病电子杂志, 2020, 8(13): 166. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXJH202013142.htm HE L J, XU Q C. Efficacy Observation of Jieyu Qingxin Anshen Decoction in Treatment of Depression with Liver Qi Stagnation and Disturbing Heart Syndrome[J]. Cardiovascular Disease Journal Of integrated traditional Chinese and Western Medicine, 2020, 8(13): 166. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXJH202013142.htm
[6]	宋宝华, 戴红, 沈仲夏, 等. 解郁清心安神汤联合平腕立指针刺手法治疗抑郁症临床疗效及安全性观察[J]. 中华中医药学刊, 2020, 38(5): 158-161. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202005037.htm SONG B H, DAI H, SHEN Z X, et al. Clinical Efficacy and Safety Observation of Jieyu Qingxin Anshen Decoction Combined with Needling by Horizontal Wrist and Vertical Fingersfor Treatment of Depression[J]. Chinese Archives of Traditional Chinese Medicine, 2020, 38(5): 158-161. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202005037.htm
[7]	李念, 梁雪梅, 刘可智. 抑郁症快感缺失的特点及对症状严重程度和短期预后的影响[J]. 现代医药卫生, 2021, 37(3): 392-395. doi: 10.3969/j.issn.1009-5519.2021.03.009 LI N, LIANG X M, LIU K Z. The traits of anhedonia of depression and its effects on symptoms severity and short-term clinical outcome[J]. Journal of Modern Medicine & Health, 2021, 37(3): 392-395. doi: 10.3969/j.issn.1009-5519.2021.03.009
[8]	李孝君, 肖锋, 肖茂良. 归脾汤结合文拉法辛治疗恶性肿瘤相关中重度抑郁症的临床研究[J]. 中医药导报, 2020, 26(12): 65-68. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202012018.htm LI X J, XIAO F, XIAO M L. Clinical study on Guipi Decoction Combined with venlafaxine in the treatment of malignant tumor related moderate and severe depression[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2020, 26(12): 65-68. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202012018.htm
[9]	张燕, 申军. 滋肾平颤汤联合多巴丝肼片对老年帕金森病伴失眠症病人PSQI评分, TESS评分及生活质量的影响[J]. 中西医结合心脑血管病杂志, 2019, 17(24): 4046-4050. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY201924046.htm ZHANG Y, SHEN J. Influences of Zishen Pingchan Decoction and Benserazide Tablets on PSQI, TESS Score and Quality of Life in the Elderly Parkinson's Disease Patients with Insomnia[J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2019, 17(24): 4046-4050. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY201924046.htm
[10]	廖飞文, 曾德志, 祝峰. 奥氮平联合艾司西酞普兰治疗抑郁症的疗效观察[J]. 神经损伤与功能重建, 2021, 16(7): 430-431. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202107018.htm LIAO F W, ZEGN D Z, ZHU F. Observation on the efficacy of olanzapine combined with escitalopram in the treatment of depression[J]. Neural Injury and Functional Reconstruction, 2021, 16(7): 430-431 https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202107018.htm
[11]	陈克龙, 陈凌, 宋成城, 等. 逍遥散合半夏厚朴汤对肝郁脾虚型抑郁症患者认知功能和事件相关电位P300的影响[J]. 中华全科医学, 2022, 20(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.002425 CHEN K L, CHEN L, SONG C C, et al. Effect of Xiaoyao Powder and Banxia Houpu Decoction on cognitive function and event-related potential P300 in patients with liver depression and spleen deficiency depression[J]. Chinese Journal of General Practice, 2022, 20(4): 665-668. doi: 10.16766/j.cnki.issn.1674-4152.002425
[12]	鲜慈英, 凌志峰, 黄斌, 等. 中医药治疗抑郁症研究现状[J]. 湖北民族大学学报: 医学版, 2020, 37(1): 75-78. https://www.cnki.com.cn/Article/CJFDTOTAL-FBMZ202001020.htm XIAN C Y, LING Z F, HUANG B, et al. Research status of depression treated with traditional Chinese medicine[J]. Journal of HuBei Minzu University(Medical Edition), 2020, 37(1): 75-78. https://www.cnki.com.cn/Article/CJFDTOTAL-FBMZ202001020.htm
[13]	沈波, 胡佳, 颜延凤, 等. 徐景藩运用疏肝解郁法治疗肝脾不和之郁证的思考[J]. 中国临床研究, 2021, 34(6): 829-831. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202106025.htm SHEN B, HU J, YAN Y F, et al. Xu Jingfan's thinking on the treatment of depression syndrome of liver spleen disharmony by soothing the liver and resolving depression[J]. Chinese Journal of Clinical Research, 2021, 34(6): 829-831. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202106025.htm
[14]	戴建锋. 小柴胡汤对抑郁症患者睡眠质量及神经功能相关因子水平的影响[J]. 福建中医药, 2022, 53(1): 7-9. https://www.cnki.com.cn/Article/CJFDTOTAL-FJZY202201003.htm DAI J F. Effects of Xiaochaihu Decoction on Sleep Quality and Nerve Function Related Factors in Patients with Depression[J]Fujian Journal of Traditional Chinese Medicine, 2022, 53(1): 7-9. https://www.cnki.com.cn/Article/CJFDTOTAL-FJZY202201003.htm
[15]	孙守强, 高媛, 程伟. 解郁清心安神汤治疗抑郁症肝郁化火、扰心伤神证疗效观察[J]. 中医学报, 2018, 33(5): 870-874. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201805042.htm SUN S Q, GAO Y, CHENG W. Efficacy Observation of Jieyu Qingxin Anshen Decoction in Treatment of Depression with Liver Qi Stagnation and Disturbing Heart Syndrome[J]. Acta Chinese Medicine, 2018, 33(5): 870-874. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZK201805042.htm
[16]	文誉坤, 陈春妹, 张福利. 温胆汤及其类方治疗抑郁症的研究进展[J]. 江苏中医药, 2021, 53(12): 74-77. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY202112024.htm WEN Y K, CHEN C M, ZHANG F L. Review of Treatment of Depression with Wendan Decoction[J]. Jiangsu Journal of Traditional Chinese Medicine, 2021, 53(12): 74-77. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY202112024.htm
[17]	VASSOU C, GEORGOUSOPOULOU E, YANNAKOULIA M, et al. Irrational beliefs triggers depression and anxiety symptoms, and increase inflammation and oxidative stress surrogate markers of cardiovascular disease risk; The Attica epidemiological study (2002-2012)[J]. Atherosclerosis, 2021, 331(1): e49. DOI: 10.1016/j.atheroselerosis.2021.06.138.
[18]	AKSOY H, ERGUN T, AKKIPRIK M, et al. The impact of antipsoriatic treatment on serum pro-DNF, BDNF levels, depression, anxiety scores and quality of life[J]. Dermatol Ther, 2021, 34(2): e14872. DOI: 10.1111/dth.14872.
[19]	BULJUBASIC D, DRENJANCEVIC I, KIBEL A, et al. Myeloperoxidase (MPO) and high sensitivity C-reactive protein (hsCRP) as inflammatory biomarkers of endothelial and leukocyte activation in overweight hypertensive patients[J]. Arterial Hypertens, 2021, 1(1): 14-21. http://www.researchgate.net/publication/351466883_Myeloperoxidase_MPO_and_high_sensitivity_C-reactive_protein_hsCRP_as_inflammatory_biomarkers_of_endothelial_and_leukocyte_activation_in_overweight_hypertensive_patients
[20]	唐颖, 张素娟, 赵蕊, 等. 健脾疏肝汤联合文拉法辛治疗复发性抑郁障碍疗效及对脑源性神经营养因子、抗氧化能力的影响[J]. 四川中医, 2020, 38(10): 134-137. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY202010043.htm TANG Y, ZHANG S J, ZHAO R, et al. Effect of Using Jianpi Shugan Decoction Combined with Venlafaxine in the Treatment of Recurrent Depression and Its Influence on Brain-derived Neurotrophic Factor and Antioxidant Capacit[J]. Journal of Sichuan of Traditional Chinese Medicine, 2020, 38(10): 134-137. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY202010043.htm
[21]	雷秀雯, 李艳红, 黄松翠, 等. 羟异栀子苷对抑郁大鼠HPA轴的影响及机制研究[J]. 浙江中医药大学学报, 2021, 45(9): 977-984. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202109007.htm LEI X W, LI Y H, HUANG S C, et al. Effect and Mechanism of Hydroxyisogeniposide on HPA Axis of Depression Rats[J]. Journal of Zhejiang Chinese Medical University, 2021, 45(9): 977-984. https://www.cnki.com.cn/Article/CJFDTOTAL-BHON202109007.htm
[22]	高亮, 陈瑞, 孙志华, 等. 柴胡皂苷A对脑外伤大鼠海马神经元自噬及AMPK-mTORC1通路的影响[J]. 现代药物与临床, 2022, 37(1): 11-18. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202201002.htm GAO L, CHEN R, SUN Z H, et al. Effects of saikosaponin A on autophagy and AMPK-mTORC1 pathway in hippocampal neurons of rats with traumatic brain injury[J]. Drugs & Clinic, 2022, 37(1): 11-18. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW202201002.htm
[23]	李会英, 赵晓丽, 王丽, 等. 川陈皮素对高糖诱导的大鼠肾小球系膜细胞炎症因子和氧化应激水平的影响[J]. 中国新药杂志, 2019, 28(20): 2537-2542. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXYZ201920030.htm LI H Y, ZHAO X L, WANG L, et al. Effects of nobiletin on high glucose-induced inflammatory cytokines and oxidative stress in rat mesangial cells[J]. Chinese Journal of New Drugs, 2019, 28(20): 2537-2542. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXYZ201920030.htm

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Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression

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