Volume 21 Issue 5
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JIN Zikai, HU Yanqi, ZHANG Lida, ZHANG Junyu, LUO Foci, HAN Wei. Advances of miR-124 in cerebral ischemia-reperfusion injury[J]. Chinese Journal of General Practice, 2023, 21(5): 838-843. doi: 10.16766/j.cnki.issn.1674-4152.002996
Citation: JIN Zikai, HU Yanqi, ZHANG Lida, ZHANG Junyu, LUO Foci, HAN Wei. Advances of miR-124 in cerebral ischemia-reperfusion injury[J]. Chinese Journal of General Practice, 2023, 21(5): 838-843. doi: 10.16766/j.cnki.issn.1674-4152.002996
shu

Advances of miR-124 in cerebral ischemia-reperfusion injury

doi: 10.16766/j.cnki.issn.1674-4152.002996
  • 1.

    Spine Department, Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100102, China

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 81973933

 皖人才办[2020]4号

 2017070802D151

 gxbjZD16

 2016H098

 2020efyzc03

  • Received Date: 2022-01-10
    Available Online: 2023-07-10
    Abstract
  • MicroRNAs (miRNAs) are a class of evolutionarily highly conserved non-coding medium-stranded small molecule RNAs that can participate in regulating the pathophysiological processes of cerebral ischemia-reperfusion injury (CIRI). They are also considered as potential diagnostic biomarkers of cerebral ischemia (CI). miR-124 is a preferentially expressed miRNA in the cerebral cortex and cerebellum, which binds to multiple targets in the body after ischemic brain injury. It regulates the development of ischemic brain injury through various mechanisms such as regulation of apoptosis, autophagy, neuroinflammation, oxidative stress, promotion of neuroprotection and regeneration and inhibition of excitatory amino acid toxicity. In addition, it has a certain potential for neurorestoration by regulating the development of brain injury. Moreover, it has a negative regulatory role in regulating apoptosis and neuroinflammation. However, there is a paucity of evidence on miR-124 regulation of ischemic brain injury at the clinical level. Therefore, its potential as a diagnostic biomarker and therapeutic target for ischemic brain injury needs to be further demonstrated in extensive clinical trials.

     

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