Volume 21 Issue 6
Jun.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(6): 940-944
WANG Mengge, LI Man, CHANG Yuhuan, LYU Lili, YE Guoliu. Predictive value of HIST1H3D in lymph node metastasis of early cervical cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 940-944. doi: 10.16766/j.cnki.issn.1674-4152.003020
Citation: WANG Mengge, LI Man, CHANG Yuhuan, LYU Lili, YE Guoliu. Predictive value of HIST1H3D in lymph node metastasis of early cervical cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 940-944. doi: 10.16766/j.cnki.issn.1674-4152.003020
shu

Predictive value of HIST1H3D in lymph node metastasis of early cervical cancer

doi: 10.16766/j.cnki.issn.1674-4152.003020

  • Department of Obstetrics and Gynecology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 gxyq2021190

 20210338

  • Received Date: 2022-10-21
    Available Online: 2023-08-26
    Abstract
  •   Objective  To analyze the high-risk factors of lymph node metastasis in early cervical cancer, and study the predictive value of HIST1H3D in lymph node metastasis of cervical cancer.  Methods  A total of 40 patients with early cervical squamous cell carcinoma who underwent radical hysterectomy in Department of Obstetrics and Gynecology from January to December 2021 and 124 patients with early cervical squamous cell carcinoma from January 2016 to December 2020 were selected from the First Affiliated Hospital of Bengbu Medical College. The expression difference of HIST1H3D in lymph node metastasis group and non-metastasis group was analyzed by RT-qPCR, Western Blot and immunohistochemistry. Chi-square test and survival curve analysis were used to analyze the influence of HIST1H3D on the clinical characteristics and survival of lymph node metastasis group and non-metastasis group of early stage cervical carcinoma. The influencing factors of lymph node metastasis were analyzed by binary logistic regression.  Results  FIGO stage (χ2=30.491, P < 0.001), tumor size (χ2=8.362, P < 0.004), infiltration of lymphatic vascular space (P < 0.001), vaginal involvement (χ2=29.350, P < 0.001) and HIST1H3D expression (χ2=4.148, P < 0.042) were significantly related to lymph node metastasis. Overexpression of HIST1H3D gene was a high-risk factor for lymph node metastasis in early cervical cancer. The survival rate of patients with positive lymph nodes was worse (P=0.0136). There was significant difference in survival rate between the high and low expression groups of HIST1H3D, and the low expression group of HIST1H3D had a longer survival time (P=0.019). ROC curve showed that when HIST1H3D immunohistochemical score was 5, the area under the curve (AUC) was 0.704, the sensitivity was 89.29%, the specificity was 64.71%. At this time, the prediction effect of lymph node metastasis was the best (P < 0.001).  Conclusion  HIST1H3D has predictive value for lymph node metastasis of early stage cervical cancer.

     

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