Volume 21 Issue 6
Jun.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(6): 1008-1011
LI Dan, WU Wanbo, SHEN Siping, YAO Lili, YANG Junyu, YANG Jianjun. Correlation between preoperative ultrasound parameters and the risk of cervical lymph node metastasis in papillary thyroid cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 1008-1011. doi: 10.16766/j.cnki.issn.1674-4152.003037
Citation: LI Dan, WU Wanbo, SHEN Siping, YAO Lili, YANG Junyu, YANG Jianjun. Correlation between preoperative ultrasound parameters and the risk of cervical lymph node metastasis in papillary thyroid cancer[J]. Chinese Journal of General Practice, 2023, 21(6): 1008-1011. doi: 10.16766/j.cnki.issn.1674-4152.003037
shu

Correlation between preoperative ultrasound parameters and the risk of cervical lymph node metastasis in papillary thyroid cancer

doi: 10.16766/j.cnki.issn.1674-4152.003037

  • Department of Ultrasound, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2021KY1090

  • Received Date: 2023-02-17
    Available Online: 2023-08-26
    Abstract
  •   Objective  To investigate the relationship between preoperative ultrasonography parameters and the risk of cervical lymph node metastasis in papillary thyroid carcinoma (PTC), in order to provide evidence for clinical treatment and prognosis evaluation.  Methods  A total of 148 patients with PTC who received surgical treatment in Huzhou Central Hospital from June 2021 to June 2022 were selected as subjects, and were divided into metastatic group (59 cases) and non-metastatic group (89 cases) according to cervical lymph node metastasis. The general data and preoperative conventional ultrasound parameters (tumor maximum diameter, boundary, morphology, distance from capsule, etc.) were compared between the two groups. Pearson correlation was used to analyze the correlation between PTC ultrasound image features and cervical lymph node metastasis. Multivariate logistic regression was used to analyze the influencing factors of cervical lymph node metastasis of PTC.  Results  The micro-calcification, distance from the capsule < 1 mm, and the maximum diameter of the tumor >7 mm in the metastatic group were more than those in the non-metastatic group (P < 0.05). Pearson correlation analysis showed that cervical lymph node metastasis was positively correlated with micro-calcification (r=0.227, P < 0.05), distance from capsule (r=0.293, P < 0.05), and maximum tumor diameter (r=0.360, P < 0.05). Multivariate logistic regression analysis showed that micro-calcification (OR=2.601, 95% CI: 1.049-6.452), distance from capsule < 1 mm (OR=2.955, 95% CI: 1.102-7.922), and the largest tumor diameter >7 mm (OR=2.965, 95% CI: 1.095-8.031) were risk factors for cervical lymph node metastasis in PTC (all P < 0.05).  Conclusion  The appearance of micro-calcification, distance from the capsule < 1 mm, and maximum diameter of the tumor > 7 mm suggest that PTC may have the risk of cervical lymph node metastasis.

     

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    • References(17)
  • [1]
    TONG Y Y, ZHANG J W, WEI Y, et al. Ultrasound-based radiomics analysis for preoperative prediction of central and lateral cervical lymph node metastasis in papillary thyroid carcinoma: a multi-institutional study[J]. BMC Med Imaging, 2022, 22(1): 82. doi: 10.1186/s12880-022-00809-2
    [2]
    ZHAN L, FENG H F, YU X Z, et al. Clinical and prognosis value of the number of metastatic lymph nodes in patients with papillary thyroid carcinoma[J]. BMC Surg, 2022, 22(1): 235. doi: 10.1186/s12893-022-01635-7
    [3]
    IQBAL M A, WANG X, GUOLIANG Z, et al. A comparison of the efficiency of diagnostic ultrasound and magnetic resonance imaging of cervical lymph nodes in papillary thyroid carcinoma[J]. J Xray Sci Technol, 2021, 29(6): 1033-1044.
    [4]
    中国抗癌协会甲状腺癌专业委员会(CATO). 甲状腺微小乳头状癌诊断与治疗中国专家共识(2016版)[J]. 中国肿瘤临床, 2016, 43(10): 405-411. https://www.cnki.com.cn/Article/CJFDTOTAL-YRBH201906023.htm

    Thyroid Cancer Professional Committee of China Anti-Cancer Association (CATO). Chinese expert consensus on diagnosis and treatment of thyroid micropapillary carcinoma (2016 edition)[J]. Chinese Journal of Clinical Oncolog, 2016, 43(10): 405-411. https://www.cnki.com.cn/Article/CJFDTOTAL-YRBH201906023.htm
    [5]
    WONG K S, DONG F, TELATAR M, et al. Papillary thyroid carcinoma with high-grade features versus poorly differentiated thyroid carcinoma: an analysis of clinicopathologic and molecular features and outcome[J]. Thyroid, 2021, 31(6): 933-940. doi: 10.1089/thy.2020.0668
    [6]
    PÉREZ-SOTO R H, VELÁZQUEZ-FERNÁNDEZ D, ARELLANO-GUTIéRREZ G, et al. Preoperative and postoperative risk stratification of thyroid papillary microcarcinoma: a comparative study between kuma criteria and 2015 american thyroid association guidelines risk stratification[J]. Thyroid, 2020, 30(6): 857-862. doi: 10.1089/thy.2019.0698
    [7]
    KIM D H, KIM G J, KIM S W, et al. Predictive value of ipsilateral central lymph node metastasis for contralateral central lymph node metastasis in patients with thyroid cancer: Systematic review and meta-analysis[J]. Head Neck, 2021, 43(10): 3177-3184. doi: 10.1002/hed.26787
    [8]
    郭斌, 陈蕊, 王圣应, 等. 208例甲状腺乳头状癌患者颈部淋巴结转移相关因素分析[J]. 中华全科医学, 2022, 20(2): 195-198, 262. doi: 10.16766/j.cnki.issn.1674-4152.002310

    GUO B, CHEN R, WANG S Y, et al. Analysis of factors related to cervical lymph node metastasis in 208 patients with papillary thyroid carcinoma[J]. Chinese Journal of General Practice, 2022, 20(2): 195-198, 262. doi: 10.16766/j.cnki.issn.1674-4152.002310
    [9]
    SALEM F A, BERGENFELZ A, NORDENSTRÖM E, et al. Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population-based study[J]. Br J Surg, 2021, 108(6): 684-690. doi: 10.1002/bjs.12028
    [10]
    LIU C H, LIU Y W, ZHANG L, et al. Risk factors for high-volume lymph node metastases in cN0 papillary thyroid microcarcinoma[J]. Gland Surg, 2019, 8(5): 550-556. doi: 10.21037/gs.2019.10.04
    [11]
    HĆŢU L, şTEFAN P A, PICIU D. Total tumor diameter and unilateral multifocality as independent predictor factors for metastatic papillary thyroid microcarcinoma[J]. J Clin Med, 2021, 10(16): 3707. doi: 10.3390/jcm10163707
    [12]
    TALLINI G, DE LEO A, REPACI A, et al. Does the site of origin of the microcarcinoma with respect to the thyroid surface matter? a multicenter pathologic and clinical study for risk stratification[J]. Cancers (Basel), 2020, 12(1): 246. doi: 10.3390/cancers12010246
    [13]
    MALHI H S, VELEZ E, KAZMIERSKI B, et al. Peripheral thyroid nodule calcifications on sonography: evaluation of malignant potential[J]. AJR Am J Roentgenol, 2019, 213(3): 672-675. doi: 10.2214/AJR.18.20799
    [14]
    GAO Z X, LU Q, YAN J P. Value of differential diagnosis of contrast-enhanced ultrasound in benign and malignant thyroid nodules with microcalcification[J]. Oncol Lett, 2019, 17(5): 4545-4549.
    [15]
    SCHOLZ F, GRAU M, MENZEL L, et al. The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions[J]. Proc Natl Acad Sci U S A, 2020, 117(42): 26328-26339. doi: 10.1073/pnas.2008883117
    [16]
    JEONG S Y, CHUNG S R, BAEK J H, et al. Sonographic assessment of minor extrathyroidal extension of papillary thyroid microcarcinoma involving the posterior thyroid capsule[J]. Eur Radiol, 2022, 32(9): 6090-6096. doi: 10.1007/s00330-022-08765-9
    [17]
    ZHU M T, ZHENG W H, XIANG Y F, et al. The relationship between central lymph node metastasis and the distance from tumor to thyroid capsule in papillary thyroid microcarcinoma without capsule invasion[J]. Gland Surg, 2020, 9(3): 727-736. doi: 10.21037/gs-20-478
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