Volume 21 Issue 9
Sep.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(9): 1520-1522
WANG Sa, YU Hao. Correlation of serum copper and inducible nitric oxide synthase with neurological deficit and prognosis in patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2023, 21(9): 1520-1522. doi: 10.16766/j.cnki.issn.1674-4152.003160
Citation: WANG Sa, YU Hao. Correlation of serum copper and inducible nitric oxide synthase with neurological deficit and prognosis in patients with acute ischemic stroke[J]. Chinese Journal of General Practice, 2023, 21(9): 1520-1522. doi: 10.16766/j.cnki.issn.1674-4152.003160
shu

Correlation of serum copper and inducible nitric oxide synthase with neurological deficit and prognosis in patients with acute ischemic stroke

doi: 10.16766/j.cnki.issn.1674-4152.003160
  • 1.

    Department of Neurology of Wenling First People' s Hospital, Taizhou, Zhejiang 317500, China

Funds:

 LQ19H090017

  • Received Date: 2023-04-10
    Abstract
  •   Objective  To analyze the relationship between serum copper, inducible nitric oxide synthase (iNOS) levels and neurological impairment and prognosis in patients with acute ischemic stroke (AIS), and to provide reference for clinical treatment of AIS.  Methods  A total of 118 patients with AIS admitted to the Department of Neurology of Wenling First People' s Hospital from January 2020 to December 2022 were selected as the observation objects. According to NIHSS score, the AIS patients were divided into mild group (35 cases), moderate group (47 cases) and severe group (36 cases). According to mRS score, AIS patients were divided into good prognosis group (83 cases) and poor prognosis group (35 cases). In the same period, 100 healthy subjects were selected as control subjects. The levels of serum copper and iNOS were detected and compared among all groups, and the correlation between their levels and the scores of NIHSS and mRS was analyzed.  Results  The serum copper [(1 436.35±128.53) μg/L vs. (1 076.64±98.41) μg/L] and iNOS [(29.78±3.04) U/mL vs. (15.43±2.26) U/mL] levels in the observation group were significantly higher than those in the control group (all P < 0.001). Compared with the mild group, the serum copper and iNOS levels in the moderate group and the severe group showed a rising trend (all P < 0.05). Serum copper [(1 468.63±136.81) μg/L vs. (1 046.83±115.65) μg/L] and iNOS [(32.94±3.15) U/mL vs. (20.74±3.23) U/mL] levels in patients with good prognosis were significantly higher than those in the good prognosis group (all P < 0.001). Pearson correlation analysis showed that serum copper and iNOS levels in AIS patients were positively correlated with NIHSS scores and mRS scores (all P < 0.05).  Conclusion  The higher the levels, the more severe the neurological deficit and the worse the prognosis of AIS patients. The detection of the above indicators can provide certain reference for clinical diagnosis and treatment of AIS, and can be used as prognostic indicators for AIS patients.

     

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