Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1665-1668
GUO Shunan, WANG Gengming, CHEN Man, PAN Quan, ZHOU Yongchun, ZHU Chaomang. Clinical significance of lymphocyte-monocyte ratio in the prognosis of elderly patients undergoing curative chemoradiotherapy for esophageal cancer[J]. Chinese Journal of General Practice, 2023, 21(10): 1665-1668. doi: 10.16766/j.cnki.issn.1674-4152.003195
Citation: GUO Shunan, WANG Gengming, CHEN Man, PAN Quan, ZHOU Yongchun, ZHU Chaomang. Clinical significance of lymphocyte-monocyte ratio in the prognosis of elderly patients undergoing curative chemoradiotherapy for esophageal cancer[J]. Chinese Journal of General Practice, 2023, 21(10): 1665-1668. doi: 10.16766/j.cnki.issn.1674-4152.003195
shu

Clinical significance of lymphocyte-monocyte ratio in the prognosis of elderly patients undergoing curative chemoradiotherapy for esophageal cancer

doi: 10.16766/j.cnki.issn.1674-4152.003195
  • 1.

    Department of Radiation Oncology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2018A0241

 卫科教秘[2018]291号

  • Received Date: 2022-03-21
    Available Online: 2023-11-23
    Abstract
  •   Objective  To analyze the prognostic value of lymphocyte to monocyte ratio (LMR) in elderly patients with esophageal cancer (EC).  Methods  A total of 220 elderly (≥65 years) patients who underwent radical chemoradiotherapy for EC at the Radiation Oncology Department of the First Affiliated Hospital of Bengbu Medical College from January 2014 to December 2017 were enrolled, and the clinical data and laboratory test indexes of the included patients were retrospectively reviewed. By constructing receiver operating characteristic curve, the LMR at the maximum value of Youden index was 4.9, and LMR=4.9 was used as the cut-off value to divide the patients into high LMR group (>4.9, 69 cases) and low LMR group (≤4.9, 151 cases), the survival curves of the two groups were plotted by Kaplan-Meier method, log-rank method to compare the survival status of the two groups, and multivariate analysis was performed by Cox regression model.  Results  A total of 82 patients were alive in the whole group with a median overall follow-up of 45 months and a median overall survival time of 28 months. The 5-year progression-free survival rates of patients in the high and low LMR groups before radical chemoradiotherapy were 38.6% and 29.8%, respectively (P=0.005), and the 5-year overall survival rates were 47.0% and 26.5%, respectively (P=0.003). By Cox regression model multivariate analysis, the results showed that LMR value before radical chemoradiotherapy was an independent factor affecting the prognosis of elderly EC patients (HR=0.634, 95% CI: 0.422-0.954, P=0.029).  Conclusion  In elderly EC patients receiving radical chemoradiotherapy, reduced LMR prior to radical chemoradiotherapy was an independent adverse prognostic factor.

     

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