Volume 21 Issue 10
Oct.  2023
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CHEN Weier, QIU Yan, PAN Xiaohua, REN Jingjing. Progress on medication compliance of patients with multimorbidity in China[J]. Chinese Journal of General Practice, 2023, 21(10): 1745-1748. doi: 10.16766/j.cnki.issn.1674-4152.003215
Citation: CHEN Weier, QIU Yan, PAN Xiaohua, REN Jingjing. Progress on medication compliance of patients with multimorbidity in China[J]. Chinese Journal of General Practice, 2023, 21(10): 1745-1748. doi: 10.16766/j.cnki.issn.1674-4152.003215

Progress on medication compliance of patients with multimorbidity in China

doi: 10.16766/j.cnki.issn.1674-4152.003215



  • Received Date: 2022-07-28
    Available Online: 2023-11-23
  • With the acceleration of China's industrialization, urbanization and population aging process, people's production and life style and disease spectrum are constantly changing. The prevalence of chronic diseases represented by cardiovascular and cerebrovascular diseases, diabetes, chronic respiratory diseases and cancer has increased year by year. Chronic diseases have replaced infectious diseases as the major diseases that threaten human life, health and quality of life. The coexistence of chronic diseases is increasingly common in community elderly people. Compared with single chronic diseases, the emergence of comorbidities challenges the basic principles of monmorbidity management, and the interaction of multiple slow traffic diseases also causes greater health harm to the population. The coexistence of chronic diseases often has many problems, such as complex diseases, multiple drugs, and excessive medical treatment, which seriously affect the quality of life and life expectancy of the elderly, increase the economic burden of families and society, increase the national medical expenditure, and cause the waste of health resources. Chronic disease management plays an important role in improving patient health outcomes and improving their quality of life. Drug treatment is an important part of chronic disease management, an important measure to control the condition and reduce complications, and an effective means of patient prognosis and rehabilitation. However, there are differences in China, which increases the difficulty of medical staff to manage comorbid patients. This paper relies on the current situation of medication compliance with chronic diseases patients in China, the social economics, disease, patients, medical team related factors, such as patients' mental health status, cognitive level, medication plan, doctor-patient communication, medical knowledge reserve, drug prices, etc., and then discusses the important measures to improve the comorbid patients' medication compliance, finally provides reference for better management of comorbid patients.


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  • [1]
    张可可. 北京部分社区老年人慢病及老年综合征的调查分析[D]. 北京: 北京协和医学院, 2016.

    ZHANG K K. Investigation of chronic diseases and geriatric syndromes in the community-dwelling elder people in Beijing[D]. Beijing: Peking Union Medical College, 2016.
    杨直, 高静, 柏丁兮, 等. 老年慢性病共病患者治疗负担体验的质性研究[J]. 中国全科医学, 2022, 25(19): 2336-2341. doi: 10.12114/j.issn.1007-9572.2022.0169

    YANG Z, GAO J, BAI D X, et al. Experience of treatment burden in older adults with multimorbidity: a qualitative study[J]. Chinese General Practice, 2022, 25(19): 2336-2341. doi: 10.12114/j.issn.1007-9572.2022.0169
    姚元龙, 史威力, 冯娴, 等. 老年共病的研究管理策略[J]. 中华全科医学, 2022, 20(8): 1267-1270. doi: 10.16766/j.cnki.issn.1674-4152.002574

    YAO Y L, SHI W L, FENG X, et al. Research management strategies for multimorbidity in elderly patients[J]. Chinese Journal of General Practice, 2022, 20(8): 1267-1270. doi: 10.16766/j.cnki.issn.1674-4152.002574
    范潇茹, 陈莎, 施予宁, 等. 我国中老年人慢性病共病现状及其对卫生服务利用和医疗费用的影响研究[J]. 中国全科医学, 2022, 25(19): 2371-2378. doi: 10.12114/j.issn.1007-9572.2022.0220

    FAN X R, CHEN S, SHI Y N, et al. Multimorbidity prevalence and its association with health service utilization and medical costs among middle-aged and older Chinese people[J]. Chinese General Practice, 2022, 25(19): 2371-2378. doi: 10.12114/j.issn.1007-9572.2022.0220
    李英, 刘兴鹏. 常见心血管疾病服药依从性[J]. 心血管病学进展, 2020, 41(10): 1016-1020. doi: 10.16806/j.cnki.issn.1004-3934.2020.10.005

    LI Y, LIU X P. Drug compliance for common cardiovascular diseases[J]. Advances in Cardiovascular Diseases, 2020, 40(10): 1016-1020. doi: 10.16806/j.cnki.issn.1004-3934.2020.10.005
    张振香, 何福培, 张春慧, 等. 慢性病共病患者服药依从性潜在类别及其影响因素分析[J]. 中国全科医学, 2022, 25(31): 3904-3913. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202231010.htm

    ZHANG Z X, HE F P, ZHANG C H, et al. Latent class analysis and influencing factors of medication adherence in multiple chronic conditions patients[J]. Chinese General Practice, 2022, 25(31): 3904-3913. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202231010.htm
    侯晓林, 曾庆华, 赵志颖. 某三甲医院门诊老年高血压病患者服药依从性现状及影响因素分析[J]. 中国卫生事业管理, 2019, 36(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201901015.htm

    HOU X L, ZENG Q Y, ZHAO Z Y. Condition of the compliance in the eldly patients with antihypertensive therapy and its influence factors[J]. Chinese Health Service Management, 2019, 36(1): 37-39. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWSG201901015.htm
    刘英杰, 王彤, 张丹丹, 等. 北京市城区家庭医生式服务签约糖尿病患者服药依从性影响因素研究[J]. 华西医学, 2017, 32(8): 1168-1172. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYX201708007.htm

    LIU Y J, WANG T, ZHANG D D, et al. Influencing factors of medication adherence among patients with diabetes signing family doctor service contract in Beijing urban areas[J]. West China Medical Journal, 2017, 32(8): 1168-1172. https://www.cnki.com.cn/Article/CJFDTOTAL-HXYX201708007.htm
    苏丽娜. 山东省老年慢性病患者服药依从性研究[D]. 济南: 山东大学, 2018.

    SU L N. Study on the medication adherence of elderly patients with chronic disease in Shandong province[D]. Jinan: Shandong University, 2018.
    姚媛英. 社区老年共病患者服药依从性及影响因素研究[D]. 开封: 河南大学, 2018.

    YAO Y Y. The study on medication adherence adherence and influencing factors of community elderly patients with comorbidity[D]. Kaifeng: Henan University, 2018.
    王金明. 社区共病患者服药依从性及自我管理小组在共病患者管理中的应用研究[D]. 广州: 广州医科大学, 2018.

    WANG J M. Medication adherence of community multimorbidity patients and application of self-management group in multimorbidity patients management[D]. Guangzhou: Guangzhou Medical University, 2018.
    ULLBERG T, ZIA E, PETERSSON J, et al. Doctor's follow-up after stroke in the south of Sweden: an observational study from the Swedish stroke register (Riksstroke)[J]. Eur Stroke J, 2016, 1(2): 114-121. doi: 10.1177/2396987316650597
    NISHIMURA R, KATO H, KISANUKI K, et al. Treatment patterns, persistence and adherence rates in patients with type 2 diabetes mellitus in Japan: a claims-based cohort study[J]. BMJ Open, 2019, 9(3): e025806. DOI: 10.1136/bmjopen-2018-025806.
    MONDESIR F L, CARSON A P, DURANT R W, et al. Association of functional and structural social support with medication adherence among individuals treated for coronary heart disease risk factors: findings from the REasons for geographic and racial differences in stroke (REGARDS) study[J]. PLoS One, 2018, 13(6): e0198578. DOI: 10.1371/journal.pone.0198578.
    TANGKIATKUMJAI M, WALKER D M, PRADITPORNSILPA K. Association between medication adherence and clinical outcomes in patients with chronic kidney disease: a prospective cohort study[J]. Clin Exp Nephrol, 2017, 21(3): 504-512. doi: 10.1007/s10157-016-1312-6
    谢晓华, 苏正丽, 刘咏梅. 2型糖尿病合并高脂血症患者调脂药物服药依从性现状及影响因素分析[J]. 临床误诊误治, 2019, 32(11): 35-38. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ201911009.htm

    XIE X H, SU Z L, LIU Y M. Adherence to lipid-regulating medications in patients with type 2 diabetes mellitus complicated with hyperlipidemia and influencing factors[J]. Clinical Misdiagnosis & Mistherapy, 2019, 32(11): 35-38. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ201911009.htm
    曾珊, 唐芳, 王怡琨, 等. 392例慢性肾脏病患者参与慢病管理依从性的影响因素分析[J]. 中国中西医结合肾病杂志, 2018, 19(1): 25-27. https://www.cnki.com.cn/Article/CJFDTOTAL-JXSB201801011.htm

    ZENG S, TANG F, WANG Y K. Analysis of the compliance and associated influencial factors of 392 chronic kidney disease patients in chronic disease management[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2018, 19(1): 25-27. https://www.cnki.com.cn/Article/CJFDTOTAL-JXSB201801011.htm
    余灵芝, 袁红梅. 维持性血液透析合并高血压患者降压药服药依从性及影响因素分析[J]. 中国慢性病预防与控制, 2020, 28(10): 770-773. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB202010016.htm

    YU L Z, YUAN H M. Analysis of antihypertensive medication compliance and influencing factors in patients with maintenance hemodialysis combined with hypertension[J]. Chinese Journal of Prevention and Control of Chronic Diseases, 2020, 28(10): 770-773. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB202010016.htm
    何苗, 张春华, 唐晓君, 等. 重庆市慢病管理系统中2型糖尿病患者就诊倾向及影响因素分析[J]. 复旦学报(医学版), 2017, 44(2): 162-167. doi: 10.3969/j.issn.1672-8467.2017.02.006

    HE M, ZHANG C H, TANG X J, et al. Influencing factors of health seeking intention among patients with type 2 diabetes in Chongqing chronic disease management system[J]. Fudan University Journal of Medical Sciences, 2017, 44(2): 162-167. doi: 10.3969/j.issn.1672-8467.2017.02.006
    LIN L W, TENG G G, LIM A Y N, et al. Cost-effectiveness of an adherence-enhancing intervention for gout based on real-world data[J]. Int J Rheum Dis, 2019, 22(4): 545-554.
    王金明, 林盛强, 杨玉明, 等. 社区共病患者服药依从性及影响因素调查分析[J]. 中国全科医学, 2017, 20(23): 2827-2831. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201723006.htm

    WANG J M, LIN S Q, YANG Y M, et al. Medication adherence and its influencing factors of community multimorbidity patients[J]. Chinese General Practice, 2017, 20(23): 2827-2831. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX201723006.htm
    BAE J P, DOBESH P P, KLEPSER D G, et al. Adherence and dosing frequency of common medications for cardiovascular patients[J]. Am J Manag Care, 2012, 18(3): 139-146.
    万荣荣, 刘雪君, 王爽, 等. 天津某社区心血管病危险人群他汀类药物使用依从性的研究[J]. 中华全科医师杂志, 2020, 19(7): 606-611.

    WAN R R, LIU X J, WANG S, et al. Compliance of statin use among cardiovascular risk residents in a community in Tianjin[J]. Chinese Journal of General Practitioners, 2020, 19(7): 606-611.
    王永馨, 李小菊, 井明霞, 等. 社区老年高血压患者服药依从性影响因素的路径分析[J]. 中国全科医学, 2021, 24(4): 503-508. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202104016.htm

    WANG Y X, LI X J, JING M X, et al. Path analysis of influencing factors for medication compliance in community-dwelling elderly patients with hypertension[J]. Chinese General Practice, 2021, 24(4): 503-508. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYX202104016.htm
    陈国亮, 王丽丹, 杨磊, 等. 焦虑抑郁对冠心病患者药物治疗依从性的影响[J]. 大连医科大学学报, 2018, 40(2): 138-141, 146. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201802011.htm

    CHEN G L, WANG L D, YANG L, et al. Effect of anxiety and depression on the compliance in secondary prevention for patient with coronary heart disease[J]. Journal of Dalian Medical University, 2018, 40(2): 138-141, 146. https://www.cnki.com.cn/Article/CJFDTOTAL-DLYK201802011.htm
    张鑫, 兰晶. 冠心病合并高血压患者二级预防服药依从性及影响因素[J]. 中国卫生工程学, 2019, 18(4): 559-561. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWX201904030.htm

    ZHANG X, LAN J. Secondary preventive medication adherence and influencing factors in patients with coronary heart disease and hypertension[J]. Chinese Journal of Public Health Engineering, 2019, 18(4): 559-561. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWX201904030.htm
    孙爱华, 旷璐, 王跃坤, 等. 肺动脉高压患者服药依从性现状及其影响因素研究[J]. 中华现代护理杂志, 2021, 27(11): 1472-1476.

    SUN A H, KUANG L, WANG Y K, et al. Current status and influencing factors of medication adherence in patients with pulmonary arterial hypertension[J]. Chinese Journal of Modern Nursing, 2021, 27(11): 1472-1476.
    KELLY A, TYMMS K, WIT M D, et al. Patient and caregiver priorities for medication adherence in gout, osteoporosis and rheumatoid arthritis: nominal group technique[J]. Arthritis Care Res, 2020, 72(10): 1410-1419.
    王军霞, 陈嘉林, 武琳, 等. 心房颤动抗凝管理服务的研究进展[J]. 中华全科医师杂志, 2020, 19(4): 368-371.

    WANG J X, CHEN J L, WU L, et al. Research progress of anticoagulant management service for atrial fibrillation[J]. Chinese Journal of General Practitioners, 2020, 19(4): 368-371.
    ZHANG X T, WEN D, LIANG J, et al. How the public uses social media wechat to obtain health information in china: a survey study[J]. BMC Med Inform Decis Mak, 2017, 17(Suppl 2): 66.
    闫佳佳, 李佳, 何秋毅, 等. 医联体内药师通过手机App全程管理出院慢性病患者实践[J]. 中华医院管理杂志, 2019, 35(4): 338-340.

    YAN J J, LI J, HE Q Y, et al. Practice of mobile App-based chronic care management for discharged patients by pharmacists within a medical alliance[J]. Chinese Journal of Hospital Administration, 2019, 35(4): 338-340.
    刘晓琳, 牛俊坤, 吴静, 等. 专业团队多途径健康教育模式对炎症性肠病患者自我管理的影响[J]. 中华消化杂志, 2021, 41(2): 112-117.

    LIU X L, NIU J K, WU J, et al. Effect of multi-channel health education model by professional team on self-management of patients with inflammatory bowel disease[J]. Chinese Journal of Digestion, 2021, 41(2): 112-117.
    WANG L, FAN R, ZHANG C, et al. Patients' educational program could improve azathioprine adherence in Crohn's disease maintenance therapy[J]. Gastroenterol Res Pract, 2020, 2020: 6848293. DOI: 10.1155/2020/6848293.
    PALMER M J, BARNARD S, PEREL P, et al. Mobile phone-based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults[J]. Cochrane Database Syst Rev, 2018, 6(6): CD012675. DOI: 10.1002/14651858.CD012675.
    张立新, 相爽, 营晓, 等. 微信干预对急性心肌梗死患者出院后服药依从性及生活方式的影响[J]. 中华现代护理杂志, 2020, 26(14): 1920-1923.

    ZHANG L X, XIANG S, YING X, et al. Effects of wechat intervention on medication compliance and lifestyle of patients with acute myocardial infarction after discharge[J]. Chinese Journal of Modern Nursing, 2020, 26(14): 1920-1923.
    MAGACHO E J C, RIBEIRO L C, CHAOUBAH A, et al. Adherence to drug therapy in kidney disease[J]. Braz J Med Biol Res, 2011, 44(3): 258-262.
    刘西玲, 常巧云, 鱼红, 等. 积极心理干预对阿尔茨海默病患者药物治疗依从性及精神行为障碍的影响[J]. 国际精神病学杂志, 2017, 44(6): 1091-1094. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ201706039.htm

    LIU X L, CHANG Q Y, YU H, et al. Effect of positive psychological intervention on compliance with drug therapy and behavioral and psychogical symptoms of dementia in patients with Alzheimer disease[J]. Journal of International Psychiatry, 2017, 44(6): 1091-1094. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ201706039.htm
    何光秀. 药品福利视角下慢性病患者健康不平等的影响因素及其分解研究: 基于甘、川、冀、浙、津的调研数据[D]. 南京: 南京中医药大学, 2020.

    HE G X. Study on the influencing factors and decomposition of health inequality of patients with chronic disease from the perspective of drug welfare[D]. Nanjing: Nanjing University of Chinese Medicine, 2020.
    于长永. "4+7"药品带量采购的实践效果与制度隐忧[J]. 西南民族大学学报(人文社科版), 2020, 41(4): 34-39. https://www.cnki.com.cn/Article/CJFDTOTAL-XNZS202004006.htm

    YU C J. The practical effect and system worries of "4+7" drug procurement with quantity[J]. Journal of Southwest University for Nationalities(Humanities and Social Science Section), 2020, 41(4): 34-39. https://www.cnki.com.cn/Article/CJFDTOTAL-XNZS202004006.htm
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