Volume 21 Issue 10
Oct.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1778-1782
HONG Jing, ZHU Qing, CAI Xintian, LIU Shasha, WU Ting, WANG Guoliang, LI Nanfang. Association of serum MCP-1 levels with vasculitis: A meta-analysis[J]. Chinese Journal of General Practice, 2023, 21(10): 1778-1782. doi: 10.16766/j.cnki.issn.1674-4152.003223
Citation: HONG Jing, ZHU Qing, CAI Xintian, LIU Shasha, WU Ting, WANG Guoliang, LI Nanfang. Association of serum MCP-1 levels with vasculitis: A meta-analysis[J]. Chinese Journal of General Practice, 2023, 21(10): 1778-1782. doi: 10.16766/j.cnki.issn.1674-4152.003223
shu

Association of serum MCP-1 levels with vasculitis: A meta-analysis

doi: 10.16766/j.cnki.issn.1674-4152.003223
  • 1.

    Hypertension Center of People ' s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang 830001, China

Funds:

 2019D01C153

 2021D01C205

  • Received Date: 2022-12-15
    Available Online: 2023-11-23
    Abstract
  •   Objective  Monocyte chemotactic protein 1 (MCP-1) is a proinflammatory chemokine that is involved in the pathogenesis of vasculitis. The purpose of this meta-analysis is to determine the relationship between serum MCP-1 levels with vasculitis.  Methods  Articles were identified by searching Web of Science, PubMed, Wanfang, and CNKI databases (up to July 1, 2020). Two independent evaluators screened literature according to inclusion and exclusion criteria, extracted relevant data, and then used Review Manager software (version 5.4.0) and Stata 12.0 software for meta-analysis.  Results  A total of 13 original articles of vasculitis (1 034 participants) were finally included. The vasculitis group had a higher level of MCP-1 than healthy control (SMD=1.23, 95% CI: 0.48-1.98, P=0.001). Subgroup analysis based on the classification of vasculitis indicated that the serum MCP-1 levels in small vessel vasculitis patients were significantly higher compared to healthy controls, but not in large vessel vasculitis and Behcet ' s disease patients.  Conclusion  Meta-analysis shows that serum MCP-1 level is significantly higher in patients with vasculitis, especially small vessel vasculitis, than in healthy controls. It suggests that this index has some clinical value for the diagnosis of vasculitis.

     

    • FullText(HTML)
  • loading
    • References(24)
  • [1]
    FELICETTI M, TREPPO E, POSARELLI C, et al. One year in review 2020: vasculitis[J]. Clin Exp Rheumatol, 2020, 124(2): 3-14.
    [2]
    侯传云, 李志军. 系统性血管炎的诊断与治疗[J]. 中华全科医学, 2020, 18(5): 710-711. http://www.zhqkyx.net/article/id/450159ed-8208-42b3-bea4-23f0ad841586

    HOU C Y, LI Z J. Diagnosis and treatment of systemic vasculitis[J]. Chinese Journal of General Practice, 2020, 18(5): 710-711. http://www.zhqkyx.net/article/id/450159ed-8208-42b3-bea4-23f0ad841586
    [3]
    ZHU Q, LIU S S, HEIZHATI M, et al. Systemic vasculitis: an important and underestimated cause of malignant hypertension[J]. Cardiovasc Innov Appl, 2019, 4(2): 99-108.
    [4]
    JENNETTE J C, FALK R J, BACON P A, et al. 2012 revised international chapel hill consensus conference nomenclature of vasculitides[J]. Arthritis Rheum, 2013, 65(1): 1-11. doi: 10.1002/art.37715
    [5]
    LIU S S, LI N F, ZHU Q, et al. Increased serum MCP-1 levels in systemic vasculitis patients with renal involvement[J]. J Interferon Cytokine Res, 2018, 38(9): 406-412. doi: 10.1089/jir.2017.0140
    [6]
    DESHMANE S L, KREMLEV S, AMINI S, et al. Monocyte chemoattractant protein-1 (MCP-1): an overview[J]. J Interferon Cytokine Res, 2009, 29(6): 313-326. doi: 10.1089/jir.2008.0027
    [7]
    HALLER H, BERTRAM A, NADROWITZ F, et al. Monocyte chemoattractant protein-1 and the kidney[J]. Curr Opin Nephrol Hypertens, 2016, 25(1): 42-49. doi: 10.1097/MNH.0000000000000186
    [8]
    CID M C, HOFFMAN M P, HERNÁNDEZ-RODRÍGUEZ J, et al. Association between increased CCL2 (MCP-1) expression in lesions and persistence of disease activity in giant-cell arteritis[J]. Rheumatology (Oxford), 2006, 45(11): 1356-1363. doi: 10.1093/rheumatology/kel128
    [9]
    ELLINGSEN T, ELLING P, OLSON A, et al. Monocyte chemoattractant protein 1 (MCP-1) in temporal arteritis and polymyalgia rheumatica[J]. Ann Rheum Dis, 2000, 59(10): 775-780. doi: 10.1136/ard.59.10.775
    [10]
    张铭明, 张锐, 杨小珂, 等. 抗中性粒细胞胞浆抗体相关性血管炎患者中MIF及MCP-1的检测及临床意义[J]. 国际检验医学杂志, 2020, 41(13): 1581-1584. doi: 10.3969/j.issn.1673-4130.2020.13.011

    ZHANG M M, ZHANG R, YANG X K, et al. The study of MIF and MCP-1 in patients with anti-neutrophil cytoplasmic antibody associated vasculitis[J]. International Journal of Laboratory Medicine, 2020, 41(13): 1581-1584. doi: 10.3969/j.issn.1673-4130.2020.13.011
    [11]
    MIRIOGLU S, CINAR S, YAZICI H, et al. Serum and urine TNF-like weak inducer of apoptosis, monocyte chemoattractant protein-1 and neutrophil gelatinase-associated lipocalin as biomarkers of disease activity in patients with systemic lupus erythematosus[J]. Lupus, 2020, 29(4): 379-388. doi: 10.1177/0961203320904997
    [12]
    SUZUKI K, NAGAO T, ITABASHI M, et al. A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis[J]. Nephrol Dial Transplant, 2014, 29(6): 1168-1177. doi: 10.1093/ndt/gft469
    [13]
    OZER H T, ERKEN E, GUNESACAR R, et al. Serum RANTES, MIP-1alpha, and MCP-1 levels in Behet ' s disease[J]. Rheumatol Int, 2005, 25(6): 487-488. doi: 10.1007/s00296-004-0519-0
    [14]
    KABURAKI T, FUJINO Y, KAWASHIMA H, et al. Plasma and whole-blood chemokine levels in patients with Behcet ' s disease[J]. Graefes Arch Clin Exp Ophthalmol, 2003, 241(5): 353-358. doi: 10.1007/s00417-003-0668-y
    [15]
    ANTONELLI A, FALLAHI P, FERRARI S M, et al. Parallel increase of circulating CXCL11 and CXCL10 in mixed cryoglobulinemia, while the proinflammatory cytokine IL-6 is associated with high serum Th2 chemokine CCL2[J]. Clin Rheumatol, 2013, 32(8): 1147-1154. doi: 10.1007/s10067-013-2246-y
    [16]
    ANTONELLI A, FERRI C, FALLAHI P, et al. CXCL10 and CCL2 serum levels in patients with mixed cryoglobulinaemia and hepatitis C[J]. Dig Liver Dis, 2009, 41(1): 42-48. doi: 10.1016/j.dld.2008.04.009
    [17]
    孙伟娜, 陈院朝, 蔡文杰. 45例系统性血管炎患者炎症性因子检测结果分析[J]. 中外健康文摘, 2013, 10(28): 158.

    SUN W N, CHEN Y C, CAI W J. Analysis of inflammatory factors in 45 patients with systemic vasculitis[J]. World Health Digest Medical Periodieal, 2013, 10(28): 158.
    [18]
    DHAWAN V, MAHAJAN N, JAIN S. Role of C-C chemokines in Takayasu ' s arteritis disease[J]. Int J Cardiol, 2006, 112(1): 105-111. doi: 10.1016/j.ijcard.2005.11.101
    [19]
    WALLACE G R, FARMER I, CHURCH A, et al. Serum levels of chemokines correlate with disease activity in patients with retinal vasculitis[J]. Immunol Lett, 2003, 90(1): 59-64. doi: 10.1016/S0165-2478(03)00159-7
    [20]
    朱晴, 朱彬, 吴婷, 等. 高迁移率族蛋白水平与系统性血管炎相关性的Meta分析[J]. 中华全科医学, 2021, 19(1): 131-136. doi: 10.16766/j.cnki.issn.1674-4152.001749

    ZHU Q, ZHU B, WU T, et al. Meta-analysis of the relationship between HMGB1 level and systemic vasculitis[J]. Chinese Journal of General Practice, 2021, 19(1): 131-136. doi: 10.16766/j.cnki.issn.1674-4152.001749
    [21]
    NORRIS J M, SIMPSON B S, BALLR, et al. A modified Newcastle-Ottawa scale for assessment of study quality in genetic urological research[J]. Eur Urol, 2021, 79(3): 325-326.
    [22]
    SUGIYAMA M, WADA Y, KANAZAWA N, et al. A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy[J]. PLoS One, 2020, 15(4): e0232194. DOI: 10.1371/journal.pone.0232194.
    [23]
    TAM F W, SANDERS J S, GEORGE A, et al. Urinary monocyte chemoattractant protein-1 (MCP-1) is a marker of active renal vasculitis[J]. Nephrol Dial Transplant, 2004, 19(11): 2761-2768.
    [24]
    MORAN S M, MONACH P A, ZGAGA L, et al. Urinary soluble CD163 and monocyte chemoattractant protein-1 in the identification of subtle renal flare in anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Nephrol Dial Transplant, 2020, 35(2): 283-291.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(4)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (268) PDF downloads(9) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return