Volume 21 Issue 11
Nov.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(11): 1924-1927
LI Hong, LI Geng, LIU Xing, YU Hong. Clinical value of HE4 as a molecular marker for renal fibrosis[J]. Chinese Journal of General Practice, 2023, 21(11): 1924-1927. doi: 10.16766/j.cnki.issn.1674-4152.003259
Citation: LI Hong, LI Geng, LIU Xing, YU Hong. Clinical value of HE4 as a molecular marker for renal fibrosis[J]. Chinese Journal of General Practice, 2023, 21(11): 1924-1927. doi: 10.16766/j.cnki.issn.1674-4152.003259
shu

Clinical value of HE4 as a molecular marker for renal fibrosis

doi: 10.16766/j.cnki.issn.1674-4152.003259

  • Department of Clinical Laboratory, Wuhan Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430000, China

Funds:

 ZY2023F052

 WZ22C69

  • Received Date: 2023-06-11
    Available Online: 2024-01-13
    Abstract
  •   Objective  To investigate the changes of serum human epididymis protein 4(HE4) in patients with chronic kidney disease (CKD) and its diagnostic value for renal fibrosis.  Methods  A total of 159 patients with CKD who were treated in Wuhan Hospital of Traditional Chinese Medicine from January 2020 to January 2022 were selected and divided into CKD 1-5 stage groups, and 39 healthy subjects were selected as the control group.The levels of serum HE4, creatinine (Crea), blood urea nitrogen (Bun) and urine β2-microglobulin (β2-M) in each group were compared.The receiver operating characteristic (ROC) curve was used to evaluate the value of HE4 in the auxiliary diagnosis of CKD.The relationship between HE4 and renal fibrosis was analyzed by GEO database.  Results  Serum HE4 levels in CKD 1-5 stage patients were (84.36±7.53) pmol/L, (148.90±16.46) pmol/L, (259.80±36.93) pmol/L, (438.80±81.92) pmol/L, and (1 002.34±68.55) pmol/L, respectively, were all higher than that of control group[(33.80±1.99) pmol/L, all P < 0.05].With the progression of CKD, serum HE4 increased gradually.The areas under the curve of serum HE4, Crea, Bun and urine β2-M for predicting CKD were 0.998, 0.801, 0.748 and 0.826, respectively (all P < 0.05).The sensitivity and specificity of HE4 for the diagnosis of CKD were 0.983 and 0.949, respectively.GEO database analysis showed that HE4 gene WFDC2 was closely related to renal fibrosis, and WFDC2 gene expression was significantly increased in renal fibrosis models induced by different diseases (all P < 0.05).  Conclusion  Elevated serum HE4 level is associated with renal fibrosis and has a high clinical value for chronic renal insufficiency caused by renal fibrosis.

     

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