Volume 22 Issue 2
Feb.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(2): 269-272
SHI Xiaojuan, LI Dongfeng, ZHANG Xiaowei. Predictive value of pregestational TG/HDL-C ratio combined with cystatin C in predicting gestational diabetes in pregnant women[J]. Chinese Journal of General Practice, 2024, 22(2): 269-272. doi: 10.16766/j.cnki.issn.1674-4152.003381
Citation: SHI Xiaojuan, LI Dongfeng, ZHANG Xiaowei. Predictive value of pregestational TG/HDL-C ratio combined with cystatin C in predicting gestational diabetes in pregnant women[J]. Chinese Journal of General Practice, 2024, 22(2): 269-272. doi: 10.16766/j.cnki.issn.1674-4152.003381
shu

Predictive value of pregestational TG/HDL-C ratio combined with cystatin C in predicting gestational diabetes in pregnant women

doi: 10.16766/j.cnki.issn.1674-4152.003381
  • 1.

    Nursing Department, Affiliated Hospital of West Anhui Health Vocational College, Lu'an, Anhui 237008, China

Funds:

 SK2020A0722

 KJ2021A1367

  • Received Date: 2023-03-21
    Available Online: 2024-03-27
    Abstract
  •   Objective  This study aims to examine the association between the triglycerides to HDL cholesterol(TG/HDL-C), cystatin C levels, and insulin resistance in pre-pregnancy women. Additionally, it seeks to investigate the correlation between TG/HDL-C and cystatin C with gestational diabetes mellitus (GDM).  Methods  A total of 198 pregnant women at the Affiliated Hospital of West Anhui Health Vocational College from January 2020 to June 2022 were selected as the research objects. They were divided into two groups: the observation group (98 cases with GDM) and the control group (100 cases without GDM). General clinical data from both groups were collected and analyzed to explore the relationship between these data and GDM.  Results  There were no significant difference in education, family economic situation, diet control, exercise, smoking history, drinking history, waist circumference, SBP, DBP, FPG, ALT, AST, Cr, UA, TC, HDL-C, and LDL-C between the two groups (P>0.05). However, but there were significant difference in age, BMI, Cys-C, and LDL-C. Logistic regression analysis showed that advanced age, elevated serum Cys-C, and increased TG/HDL-C ratio were independent risk factors for GDM (P < 0.05), with corresponding OR of 1.111, 3.190 and 3.970 respectively. ROC curve analysis demonstrated that TG/HDL-C ratio had an area under the Cys-C curve (AUC) of 0.820 (P < 0.001), while Cys-C had an AUC of 0.667 (P < 0.001). The combined detection of both parameters yielded an AUC of 0.848(P < 0.001), indicating better diagnostic efficiency compared to individual tests.  Conclusion  Pregnant women with high serum TG/HDL-C ratio and Cys-C levels prior to pregnancy are at a higher risk of GDM. These two indicators hold promise for risk assessment and prediction of GDM in pregnant women.

     

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    • References(20)
  • [1]
    SWEETING A, WONG J, MURPHY H R, et al. A clinical update on gestational diabetes mellitus[J]. Endocr Rev, 2022, 43(5): 763-793. doi: 10.1210/endrev/bnac003
    [2]
    SUN H, SAEEDI P, KARURANGA S, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J]. Diabetes Res Clin Pract, 2022, 183: 109119. DOI: 10.1016/j.diabres.2021.109119.
    [3]
    SAEEDI P, PETERSOHN I, SALPEA P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition[J]. Diabetes Res Clin Pract, 2019, 157: 107843. DOI: 10.1016/j.diabres.2019.107843.
    [4]
    SERT U Y, OZGU-ERDINC A S. Gestational diabetes mellitus screening and diagnosis[J]. Adv Exp Med Biol, 2021, 1307: 231-255.
    [5]
    中华医学会妇产科学分会产科学组, 中华医学会围产医学分会, 中国妇幼保健协会妊娠合并糖尿病专业委员会, 等. 妊娠期高血糖诊治指南(2022)[第一部分][J]. 中华妇产科杂志, 2022, 57(1): 3-12.

    Obstetrics Group of Obstetrics and Gynecology Branch of Chinese Medical Association, Perinatal Medicine Branch of Chinese Medical Association, Professional Committee of Pregnancy Complicated with Diabetes of China Maternal and Child Health Association, et al. Guideline of diagnosis and treatment of hyperglycemia in pregnancy(2022)[Part one][J]. Chinese Journal of Obstetrics and Gynecology, 2022, 57(1): 3-12.
    [6]
    WEI Y L, HE A D, TANG C P, et al. Risk prediction models of gestational diabetes mellitus before 16 gestational weeks[J]. BMC Pregnancy Childbirth, 2022, 22(1): 889. doi: 10.1186/s12884-022-05219-4
    [7]
    WAKABAYASHI I, DAIMON T. Comparison of discrimination for cardio-metabolic risk by different cut-off values of the ratio of triglycerides to HDL cholesterol[J]. Lipids Health Dis, 2019, 18(1): 156-165. doi: 10.1186/s12944-019-1098-0
    [8]
    JIN H. Increased levels of glycosylated hemoglobin, microalbuminuria and serum cystatin C predict adverse outcomes in high-risk pregnancies with gestational diabetes mellitus[J]. Exp Ther Med, 2020, 19(2): 1281-1287.
    [9]
    中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志, 2021, 13(4): 315-409. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYX202112018.htm

    Chinese Diabetes Society. Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition)[J]. Chinese Journal of Diabetes Mellitus, 2021, 13(4): 315-409. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYX202112018.htm
    [10]
    BORIBOONHIRUNSARN D, SUNSANEEVITHAYAKUL P, PANNIN C, et al. Prevalence of early-onset GDM and associated risk factors in a university hospital in Thailand[J]. J Obstet Gynaecol, 2021, 41(6): 915-919. doi: 10.1080/01443615.2020.1820469
    [11]
    LIN L, WANG X Y, ZHAO W H, et al. Upregulation of Klotho aggravates insulin resistance in gestational diabetes mellitus trophoblast cells[J]. Genet Res (Camb), 2022: 1500768. DOI: 10.1155/2022/1500768.
    [12]
    LIU X L, WANG N, GAO Z. β-Carotene regulates glucose transport and insulin resistance in gestational diabetes mellitus by increasing the expression of SHBG. [J]. Clin Exp Pharmacol Physiol, 2022, 49(12): 1307-1318. doi: 10.1111/1440-1681.13712
    [13]
    赵林芳, 陈丹丹. 妊娠期甲状腺功能、糖脂代谢变化及增重与妊娠期糖尿病发生风险关系[J]. 中国计划生育学杂志, 2023, 31(7): 1727-1731. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202307039.htm

    ZHAO L F, CHEN D D. Correlation between the hypothyroidism, metabolic changes, and weight gain of pregnant women and their risk of gestational diabetes mellitus occurrence[J]. Chinese Journal of Family Planning, 2023, 31(7): 1727-1731. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202307039.htm
    [14]
    YONG H Y, SHARIFF Z M, YUSOF B, et al. Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus[J]. Sci Rep, 2020, 10(1): 84-86. doi: 10.1038/s41598-019-56962-2
    [15]
    孟耀涵, 曲翌敏, 湛永乐, 等. 妊娠糖尿病的影响因素及围产期结局[J]. 中华疾病控制杂志, 2022, 26(9): 1011-1016. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ202209005.htm

    MENG Y H, QU Y M, ZHAN Y L, et al. The influencing factors and perinatal outcomes of gestational diabetes[J]. Chinese Journal of Disease Control & Prevention, 2022, 26(9): 1011-1016. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ202209005.htm
    [16]
    骆长江, 李明珠. 孕早期血清P-LAP、NSF-1水平预测妊娠期糖尿病价值[J]. 中国计划生育学杂志, 2023, 31(7): 1703-1707. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202307036.htm

    LUO C J, LI M Z. Predictive value of the serum placental leucine aminopeptidase and nesfatin 1levels of pregnant women during the first trimester of pregnancy for their gestational diabetes mellitus[J]. Chinese Journal of Family Planning, 2023, 31(7): 1703-1707. https://www.cnki.com.cn/Article/CJFDTOTAL-JHSY202307036.htm
    [17]
    叶瑛瑛, 王金辉, 王丽君, 等. 孕妇血维生素D水平与妊娠期糖尿病相关性研究[J]. 中华全科医学, 2021, 19(1): 77-79, 119. doi: 10.16766/j.cnki.issn.1674-4152.001735

    YE Y Y, WANG J H, WANG L J, et al. Study on the relationship between serum vitamin D level and gestational diabetes mellitus in pregnant women[J]. Chinese Journal of General Practice, 2021, 19(1): 77-79, 119. doi: 10.16766/j.cnki.issn.1674-4152.001735
    [18]
    LIU P, WANG Z H, KANG S S, et al. High-fat diet-induced diabetes couples to Alzheimer's disease through inflammation-activated C/EBPβ/AEP pathway[J]. Mol Psychiatry, 2022, 27(8): 3396-3409. doi: 10.1038/s41380-022-01600-z
    [19]
    楼公先, 楼时先, 程秒鸳, 等. 孕早期FBG、HbA1c、TC、TG联合检测在妊娠期糖尿病诊断中的应用价值分析[J]. 中华全科医学, 2019, 17(5): 809-812. doi: 10.16766/j.cnki.issn.1674-4152.000798

    LOU X G, LOU S X, CHENG M Y, et al. Analysis of the application value combined detection of FBG, HbA1c, TC and TG in diagnosis of GDM in early pregnancy[J]. Chinese Journal of General Practice, 2019, 17(5): 809-812. doi: 10.16766/j.cnki.issn.1674-4152.000798
    [20]
    YOUNG K A, MATURU A, LORENZO C, et al. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans[J]. J Diabetes Complications, 2019, 33(2): 118-122. doi: 10.1016/j.jdiacomp.2018.10.018
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