Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

YAO Yao; LU Ning; CHEN Jianguo

doi:10.16766/j.cnki.issn.1674-4152.003421

Volume 22 Issue 3

Mar. 2024

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2024 > 22(3): 440-442

YAO Yao, LU Ning, CHEN Jianguo. Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2024, 22(3): 440-442. doi: 10.16766/j.cnki.issn.1674-4152.003421

Citation:

YAO Yao, LU Ning, CHEN Jianguo. Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure[J]. Chinese Journal of General Practice, 2024, 22(3): 440-442. doi: 10.16766/j.cnki.issn.1674-4152.003421

Citation:

PDF( 467 KB)

Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.003421

YAO Yao¹
, LU Ning^{1
,
,}
, CHEN Jianguo²

1.
Department of Geriatrics, Wuhu First People ' s Hospital, Wuhu, Anhui 241000, China

Funds:

2008085MH257

Received Date: 2023-11-12
Available Online: 2024-05-27

Abstract

Abstract

Objective To investigate the diagnostic value of cardiac troponin I (cTnI), N-terminal precursor brain natriuretic peptide (NT-proBNP) and carbohydrate antigen-125 (CA-125) in elderly patients with chronic heart failure who have pulmonary infection. Methods During the period between January 2020 and June 2023, we selected 40 elderly patients with chronic heart failure and pulmonary infection as the combined lung infection group, 40 elderly patients with simple heart failure as the simple heart failure group, and 40 elderly patients who underwent physical examination as the control. The study compared the levels of serum cTnI, NT-proBNP, and CA-125 among the three groups, including the group with pulmonary infection. The diagnostic efficiency of serum cTnI, NT-proBNP and CA-125 in patients with pulmonary infection was analyzed by using the ROC curve. Results The levels of serum cTnI, NT-proBNP and CA-125 were higher in patients with pulmonary infection compared to those in the simple heart failure group and control group (P < 0.05). Additionally, the levels of serum cTnI, NT-proBNP and CA-125 were higher in grade Ⅳ patients with pulmonary infection were higher than those in grade Ⅲ and grade Ⅱ, and those in grade Ⅲ were higher than those in grade Ⅱ (P < 0.05). The serum cTnI, NT-proBNP and CA-125 AUC values for diagnosing pulmonary infection with chronic heart failure alone and in combination were 0.935, 0.977, 0.996 and 1.000, respectively (P < 0.05). Conclusion In elderly patients with chronic heart failure and pulmonary infection, serum levels of cTnI, NT-proBNP and CA-125 were found to be abnormally elevated. The combined detection of these three biomarkers could improve the diagnostic efficiency of the disease.
- Elderly chronic heart failure,
- Lung infection,
- Cardiac troponin I,
- N-terminal precursor brain natriuretic peptide,
- Carbohydrate antigen-125

FullText(HTML)

References(22)

References

[1]	温连彬, 伍玉洁, 肖飞, 等. 老年慢性心力衰竭患者肺部感染病原学及危险因素与预测模型构建[J]. 中华医院感染学杂志, 2023, 33(9): 1303-1307. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202309006.htm WEN L B, WU Y J, XIAO F, et al. Etiology, risk factors and prediction model construction of pulmonary infection in elderly patients with chronic heart failure[J]. Chin J nosoc, 2023, 33(9): 1303-1307. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202309006.htm
[2]	鲍利改, 董谦. 慢性心力衰竭合并肺部感染患者MIP-2, MMP-9, D-D, miR-21表达及与病原菌类型, 心肌功能的关联性研究[J]. 临床误诊误治, 2022, 35(3): 78-83. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ202203018.htm BAO L G, DONG Q. Study on the expression of MIP-2, MMP-9, D-D and miR-21 in patients with chronic heart failure complicated with pulmonary infection and their correlation with pathogenic bacteria and myocardial function[J]. Clin misdia mistreat, 2022, 35(3): 78-83. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ202203018.htm
[3]	芦志雁, 周俊阁, 韩萍, 等. 降钙素原与超敏C反应蛋白联合胱抑素C对老年急性左心衰竭合并肺部感染的临床价值[J]. 心肺血管病杂志, 2023, 42(1): 18-22. https://www.cnki.com.cn/Article/CJFDTOTAL-XFXZ202301003.htm LU Z Y, ZHOU J G, HAN P, et al. Clinical value of procalcitonin and hypersensitive C-reactive protein combined with cystatin C in elderly patients with acute left heart failure complicated with lung infection[J]. J Card Vascu Dise, 2023, 42(1): 18-22. https://www.cnki.com.cn/Article/CJFDTOTAL-XFXZ202301003.htm
[4]	崔晓婷, 郑红晓, 李海燕, 等. 血清BNP与hs-CRP和PCT对慢性心力衰竭患者肺部感染的诊断评价[J]. 中华医院感染学杂志, 2019, 29(11): 1651-1655. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201911013.htm CUI X T, ZHENG H X, LI H Y, et al. Diagnostic evaluation of serum BNP, hs-CRP and PCT for pulmonary infection in patients with chronic heart failure[J]. Chin J Nosoc, 2019, 29(11): 1651-1655. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201911013.htm
[5]	王肖雅, 胡丹, 兰超, 等. 含免疫炎性指标的老年慢性心力衰竭患者肺部感染预测模型的构建及价值[J]. 临床误诊误治, 2022, 35(11): 59-63. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ202211013.htm WANG X Y, HU D, LAN C, et al. Construction and value of prediction model of pulmonary infection in elderly patients with chronic heart failure with immunoinflammatory indexes[J]. Clin Misdia Mistreat, 2022, 35(11): 59-63. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWZ202211013.htm
[6]	张淑艳, 申洁, 赵文慧. 老年慢性心力衰竭患者肺部感染后血清胆碱酯酶和胱抑素C及炎症因子分析[J]. 中华医院感染学杂志, 2019, 29(3): 365-368. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201903011.htm ZHANG S Y, SHEN J, ZHAO W H. Analysis of serum cholinesterase and cystatin C and inflammatory factors in elderly patients with chronic heart failure after pulmonary infection[J]. Chin J Nosoc, 2019, 29(3): 365-368. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201903011.htm
[7]	中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 慢性心力衰竭基层诊疗指南(实践版·2019)[J]. 中华全科医师杂志, 2019, 18(10): 948-956. doi: 10.3760/cma.j.issn.1671-7368.2019.10.009 Chinese Medical Association, Journal of Chinese Medical Association, General Medicine Branch of Chinese Medical Association, et al. Guideline for primary care of chronic heart failure: practice version (2019)[J]. Chin J Gene Pract, 2019, 18(10): 948-956. doi: 10.3760/cma.j.issn.1671-7368.2019.10.009
[8]	中华医学会呼吸病学分会. 中国成人社区获得性肺炎诊断和治疗指南(2016年版)[J]. 中华结核和呼吸杂志, 2016, 39(4): 253-279. doi: 10.3760/cma.j.issn.1001-0939.2016.04.005 Chinese Society of Respiratory Medicine. Guidelines for diagnosis and treatment of community-acquired pneumonia in Chinese adults (2016 edition)[J]. Chin J Tuber Respirat, 2016, 39(4): 253-279. doi: 10.3760/cma.j.issn.1001-0939.2016.04.005
[9]	CARABALLO C, DESAI N R, MULDER H, et al. Clinical implications of the New York Heart Association Classification[J]. J Am Heart Assoc, 2019, 8(23): e014240. DOI: 10.1161/JAHA.119.014240.
[10]	安春生, 陈康玉, 刘志泉, 等. 心肌致密化不全心肌病伴慢性心力衰竭患者的临床研究[J]. 中华全科医学, 2020, 18(9): 1439-1442. doi: 10.16766/j.cnki.issn.1674-4152.001527 AN C S, CHEN K Y, LIU Z Q, et al. Clinical study of patients with myocardial underdensification cardiomyopathy with chronic heart failure[J]. Chin Gene pract, 2020, 18(9): 1439-1442. doi: 10.16766/j.cnki.issn.1674-4152.001527
[11]	王剑锋, 凌华. 慢性心力衰竭患者血清可溶性细胞间黏附分子-1和半乳糖凝集素-3的表达及其临床意义[J]. 中华全科医学, 2020, 18(12): 2040-2042. doi: 10.16766/j.cnki.issn.1674-4152.001683 WANG J F, LING H. Expression and clinical significance of serum soluble intercellular adhesion molecule-1 and galactin-3 in patients with chronic heart failure[J]. Chin Gene pract, 2020, 18(12): 2040-2042. doi: 10.16766/j.cnki.issn.1674-4152.001683
[12]	吴英凤, 刘毅, 王林. 血清MMP-9, MIP-2, CD64指数在心力衰竭合并肺部感染诊断中价值及与心功能关系[J]. 中国老年学杂志, 2022, 42(4): 781-784. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202204005.htm WU Y F, LIU Y, WANG L. Value of serum MMP-9, MIP-2, CD64 index in diagnosis of heart failure complicated with pulmonary infection and relationship with cardiac function[J]. Chin J Geront, 2022, 42(4): 781-784. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202204005.htm
[13]	张琼. 血清NT-proBNP, cTnI表达与老年慢性心衰患者心室重构的相关性[J]. 中国实验诊断学, 2022, 26(9): 1308-1310. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202209012.htm ZHANG Q. Correlation between expression of serum NT-proBNP and cTnI and ventricular remodeling in elderly patients with chronic heart failure[J]. Chin Experi Diagnost, 2022, 26(9): 1308-1310. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202209012.htm
[14]	孙媛媛, 余其贵, 鲁朝玉, 等. 心力衰竭超声指数联合血清肌钙蛋白Ⅰ, 脑钠肽对老年舒张性心力衰竭患者不良心血管事件的预测价值分析[J]. 现代生物医学进展, 2021, 21(14): 2753-2757. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202114033.htm SUN Y Y, YU Q G, LU C Y, et al. Predictive value of cardiac failure ultrasound index combined with serum troponin Ⅰ and brain natriuretic peptide for adverse cardiovascular events in elderly patients with diastolic heart failure[J]. Advanc mode biomed, 2021, 21(14): 2753-2757. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202114033.htm
[15]	王伟. N末端脑钠素原, 心肌肌钙蛋白Ⅰ对老年左心衰竭合并肺部感染患者的诊断价值[J]. 吉林医学, 2023, 44(2): 402-405. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202302035.htm WANG W. Diagnostic value of N-terminal brain natriuretic peptide and cardiac troponin Ⅰ in elderly patients with left heart failure combined with pulmonary infection[J]. Jilin Med Colle, 2023, 44(2): 402-405. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202302035.htm
[16]	王国玉, 巴春贺, 李彤, 等. 老年慢性心力衰竭患者肺部感染的危险因素及其对PCT, NT-proBNP及氧化应激指标的影响[J]. 中南医学科学杂志, 2023, 51(1): 110-113. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYY202301029.htm WANG G Y, BA C H, LI T, et al. Risk factors of pulmonary infection in elderly patients with chronic heart failure and their effects on PCT, NT-proBNP and oxidative stress indexes[J]. Cent Sout J Med Scie, 2023, 51(1): 110-113. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYY202301029.htm
[17]	黄杭镇, 施晓军. CKMB, cT-nT, NT-proBNP联合检测在NSCLC并发心力衰竭患者病情评估, 预后中的价值[J]. 分子诊断与治疗杂志, 2023, 15(3): 450-453. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYQ202303022.htm HUANG H Z, SHI X J. Value of combined detection of CKMB, cT-nT and NT-proBNP in disease assessment and prognosis of patients with NSCLC complicated with heart failure[J]. J Molec Diagno Thera, 2023, 15(3): 450-453. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYQ202303022.htm
[18]	戴梅, 雷育军, 孙骥, 等. NT-proBNP联合cTnT检测在评估肺炎合并心力衰竭新生儿心肌损害损伤程度及预后的价值[J]. 安徽医学, 2023, 44(4): 405-409. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYX202304009.htm DAI M, LEI Y J, SUN J, et al. The value of NT-proBNP combined with cTnT in evaluating the degree and prognosis of myocardial damage in neonates with pneumonia complicated with heart failure[J]. Anhui Med Scie, 2023, 44(4): 405-409. https://www.cnki.com.cn/Article/CJFDTOTAL-AHYX202304009.htm
[19]	路轶晴, 段雯婷. 血清IL-1, IL-6, CA125, BNP及hsCRP水平用于评估慢性心力衰竭的临床价值[J]. 贵阳医学院学报, 2021, 46(1): 115-119. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202317040.htm LU Y Q, DUAN W T. Serum levels of IL-1, IL-6, CA125, BNP and hsCRP are used to evaluate the clinical value of chronic heart failure[J]. J Guiyang Med Colle, 2021, 46(1): 115-119. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202317040.htm
[20]	STANCIU A E, VATASESCU R G, IORGULESCU C, et al. Elevated CA-125 levels are associated with increased immune activation in coronary sinus blood samples of patients with chronic heart failure[J]. Clin Chen, 2017, 63(10): 276-287.
[21]	吴曼, 郭俊玲, 潘超, 等. 血清BNP、CA125表达在老年慢性心力衰竭预后评估中的应用[J]. 标记免疫分析与临床, 2019, 26(3): 132-136. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201903031.htm WU M, GUO J L, PAN C, et al. Application of serum BNP and CA125 expression in prognosis assessment of senile chronic heart failure[J]. Marker Immunoa Clin, 2019, 26(3): 132-136. https://www.cnki.com.cn/Article/CJFDTOTAL-BJMY201903031.htm
[22]	张艳超, 翟玉民. 血清胱抑素C及糖类抗原125对老年慢性心力衰竭患者预后的评估[J]. 中华老年心脑血管病杂志, 2019, 21(2): 137-140. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG201902007.htm ZHANG Y C, ZHAI Y M. Prognostic evaluation of serum cystatin C and carbohydrate antigen 125 in elderly patients with chronic heart failure[J]. Chin J seni card dise, 2019, 21(2): 137-140. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG201902007.htm

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (119) PDF downloads(7)

Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.003421

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Value of cTnI, NT-proBNP and CA-125 in diagnosis of pulmonary infection in elderly patients with chronic heart failure

doi: 10.16766/j.cnki.issn.1674-4152.003421

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content