Volume 22 Issue 4
Apr.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 571-573
LUO Song, WANG Xiaorui, MA Bo, QU Hongdang. Clinical effect observation of prednisone combined with sodium aescinate tablets in the treatment of facial neuritis[J]. Chinese Journal of General Practice, 2024, 22(4): 571-573. doi: 10.16766/j.cnki.issn.1674-4152.003452
Citation: LUO Song, WANG Xiaorui, MA Bo, QU Hongdang. Clinical effect observation of prednisone combined with sodium aescinate tablets in the treatment of facial neuritis[J]. Chinese Journal of General Practice, 2024, 22(4): 571-573. doi: 10.16766/j.cnki.issn.1674-4152.003452
shu

Clinical effect observation of prednisone combined with sodium aescinate tablets in the treatment of facial neuritis

doi: 10.16766/j.cnki.issn.1674-4152.003452

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 202304295107020076

 2022AH051480

 2022

  • Received Date: 2023-04-13
    Available Online: 2024-05-29
    Abstract
  •   Objective  To explore the clinical efficacy of combining sodium aescinate tablets with prednisone in the treatment of facial neuritis and to explore the clinical value of this scheme in treating facial neuritis.  Methods  This study enrolled 60 patients with facial neuropathy from January 2020 to December 2022 at the Department of Neurology, the First Affiliated Hospital of Bengbu Medical University. The patients were randomly divided into two groups using a random number table method: the control group (n=30) received conventional treatment, while the observation group (n=30) received conventional therapy along with the addition of sodium aescinate tablets. After a 30-day treatment period, the clinical effects were assessed by comparing neural function scores, House-Brackman (H-B) rating, and record adverse events between the two groups.  Results  Following clinical treatment, the observation group showed 9 patients achieving complete recovery (30.0%), 10 patients with significant improvement (33.3%), 9 were effective (30.0%), and 2 patients with no improvement (6.7%). In the control group, 7 patients achieved complete recovery (23.3%), 9 patients showed significant improvement (30.0%), 6 patients had moderate improvement (20.0%), and 8 patients showed no improvement (26.7%). The difference in total effective rate between the two groups was statistically significant (P < 0.05). The mean score of the patients in the observation group was 69.33±14.41, which was higher than that in the control group (61.63±9.45) after treatment, with a statistical difference (P < 0.05). There was no significant difference in H-B grade between the observation group and the control group (P>0.05). Additionally, no significant difference in adverse events was observed between the observation group and the control group (P>0.05).  Conclusion  The combination of sodium aescinate tablets and propionate promotes improved facial neuropathic function and enhances safety.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    SPENCER C R, IRVING R M. Causes and management of facial nerve palsy[J]. Br J Hosp Med(Lond), 2016, 77(12): 686-691. doi: 10.12968/hmed.2016.77.12.686
    [2]
    刘晓芳, 郝风玲. 面神经炎的中西医联合治疗的研究概况[J]. 中国中医药现代远程教育, 2022, 20(13): 206-208. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYY202213077.htm

    LIU X F, HAO F L. Research Overviewof Integrated Traditional Chinese and Western Medicine in the Treatment of Facial Neuritis[J]. Chinese Medicine Modern Distance Education of China, 2022, 20(13): 206-208. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYY202213077.htm
    [3]
    马艳玲. 面神经炎中西医治疗进展[J]. 湖北民族大学学报(医学版), 2020, 37(4): 52-54. https://www.cnki.com.cn/Article/CJFDTOTAL-FBMZ202004012.htm

    MA Y L. Progress in treatment of facial neuritis with traditional Chinese and Western medicine[J]. Journal of Hubei Minzu University(Medical Edition), 2020, 37(4): 52-54. https://www.cnki.com.cn/Article/CJFDTOTAL-FBMZ202004012.htm
    [4]
    任丽丽, 王武庆, 伍伟景, 等. 七叶皂苷钠治疗梅尼埃病的临床初步研究报告[J]. 中华耳科学杂志, 2023, 21(1): 6-10. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHER202301002.htm

    REN L L, WANG W Q, WU W J, et al. Preliminary Results of Sodium Aescinate in Treatment of Meniere's Disease[J]. Chinese Journal of Otology, 2023, 21(1): 6-10. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHER202301002.htm
    [5]
    官泽宇, 宋涛, 余朝文, 等. 七叶皂苷钠对氧化型低密度脂蛋白诱导的血管平滑肌细胞增殖和迁移的影响[J]. 中国临床药理学杂志, 2023, 39(5): 639-643. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ202305007.htm

    GUANG Z Y, SONG T, YU C W, et al. Effects of sodium aescinate on proliferation and migration of oxidized low-density lipoprotein induced vascular smooth muscle cells[J]. The Chinese Journal of Clinical Pharmacology, 2023, 39(5): 639-643. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ202305007.htm
    [6]
    张瑞彪, 罗永伟, 石秋艳. 阿托伐他汀钙联合七叶皂甙钠对自身免疫性脑脊髓炎大鼠血清炎症因子水平及脊髓内病变的影响[J]. 中国老年学杂志, 2018, 38(2): 300-302. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201802018.htm

    ZHANG R B, LUO Y W, SHI Q Y. Effects of atorvastatin calcium combined with sodium heptafolinate on serum levels of inflammatory factors and spinal cord lesions in autoimmune encephalomyelitis rats[J]. Chinese Journal of Gerontology, 2018, 38(2): 300-302. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201802018.htm
    [7]
    杨计策, 杨永敏, 刘德政, 等. β-七叶皂甙钠静滴治疗神经根型颈椎病疗效观察[J]. 山东医药, 2015, 55(11): 77-78. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201511035.htm

    YANG J C, YANG Y M, LIU D Z, et al. Effect of intravenous drip of sodium aescinate on cervical spondylotic radiculopathy[J]. Shandong Medical Journal, 2015, 55(11): 77-78. https://www.cnki.com.cn/Article/CJFDTOTAL-SDYY201511035.htm
    [8]
    郑茂平, 陈华东, 李绍波. 七叶皂苷钠对脊髓半横断损伤大鼠后肢运动功能的影响[J]. 现代医药卫生, 2014, 30(22): 3372-3373, 3376. https://www.cnki.com.cn/Article/CJFDTOTAL-XYWS201422009.htm

    ZHENG M P, CHEN H D, LI S B. Influence of sodium aescinate on hindlimb movement in rats with hemisection of spinal cord injury[J]. Journal of Modern Medicine & Health, 2014, 30(22): 3372-3373, 3376. https://www.cnki.com.cn/Article/CJFDTOTAL-XYWS201422009.htm
    [9]
    秦树巧, 黑丹丹. β-七叶皂苷钠辅助溶栓治疗对急性脑梗死病人血清miR-155与miR-181c表达的影响[J]. 中西医结合心脑血管病杂志, 2022, 20(16): 3042-3044. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202216045.htm

    QIN S Q, HEI D D. β-Influence of beta-heptadioloside sodium on serum miR-155 and miR-181c expression in patients with acute cerebral infarction[J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2022, 20(16): 3042-3044. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202216045.htm
    [10]
    于涛. 七叶皂苷钠与甘油果糖用于脑出血患者降颅压治疗的效果比较[J]. 中国民康医学, 2022, 34(15): 142-145. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202215042.htm

    YU T. Comparison of effects of Sodium aescinate and Glycerol fructose for lowering intracranial pressure in patients with cerebral hemorrhage[J]. Medical Journal of Chinese People's Health, 2022, 34(15): 142-145. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMYX202215042.htm
    [11]
    卜云芸, 陈琳, 戴宜武, 等. 中国特发性面神经麻痹神经修复治疗临床指南(2022版)[J]. 神经损伤与功能重建, 2023, 18(1): 1-12. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202301001.htm

    BU Y Y, CHEN L, DAI Y W, et al. Clinical Guidelines for the Repair of Idiopathic Facial Paralysis in China (2022 Edition)[J]. Neural Injury and Functional Reconstruction, 2023, 18(1): 1-12. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202301001.htm
    [12]
    中华医学会神经病学分会, 中华医学会神经病学分会神经肌肉病学组, 中华医学会神经病学分会肌电图与临床神经电生理学组. 中国特发性面神经麻痹诊治指南[J]. 中华神经科杂志, 2016, 49(2): 84-86. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202301001.htm

    Chinese Medical Association Neurology Branch, Chinese Medical Association Neurology Branch Neuromyopathy Group, Chinese Medical Association Neurology Branch Electromyography and Clinical Neurophysiology Group. Guidelines for diagnosis and treatment of Idiopathic facial paralysis in China[J]. Chinese Journal of Neurology, 2016, 49(2): 84-86. https://www.cnki.com.cn/Article/CJFDTOTAL-GWKF202301001.htm
    [13]
    高志强. 面神经功能评价标准(讨论稿)[J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(1): 22-24. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHEB200601006.htm

    GAO Z Q. Evaluation criteria of facial nerve Function (Discussion Draft)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2006, 41(1): 22-24. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHEB200601006.htm
    [14]
    MALHOTRA V, DAYASHANKARA RAO J K, ARYA V, et al. Assessment of facial nerve injury with "House and Brackmann facial nerve grading system" in patients of temporomandibular joint ankylosis operated using deep subfascial approach[J]. Natl J Maxillofac Surg, 2015, 6(2): 194-199.
    [15]
    赵朋涛, 闫聚瀚, 闫晓冬, 等. 七叶皂苷钠对肾缺血再灌注的保护作用及机制[J]. 神经药理学报, 2022, 12(5): 17-23. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJKB202205003.htm

    ZHAO P T, YAN J H, YAN X D, et al. Protective Effect and Mechanism of Sodium Aescinate on Renal Ischemia Reperfusion[J]. Acta Neuropharmacologica, 2022, 12(5): 17-23. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJKB202205003.htm
    [16]
    张涛, 徐文昱, 周素敏. 泼尼松联合七叶皂苷钠治疗面神经炎的疗效及对调节性T细胞/辅助性T细胞17细胞因子、自由基生成的影响[J]. 中国药物经济学, 2021, 16(3): 95-98. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYWA202103024.htm

    ZHANG T, XU W Y, ZHOU S M. Efficacy of Prednisone Combined with Sodium Aescinate in the Treatment of Facial Neuritis and Their Effect on the Production of Treg/Th17 Cytokines and Free Radicals[J]. China Journal of Pharmaceutical Economics, 2021, 16(3): 95-98. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYWA202103024.htm
    [17]
    顾泉, 周林, 段波. 泼尼松与β-七叶皂苷钠对急性面神经炎患者功能恢复及肌电图的影响对比[J]. 世界临床药物, 2022, 43(4): 425-430, 448. https://www.cnki.com.cn/Article/CJFDTOTAL-GWHH202204011.htm

    GU Q, ZHOU L, DUAN B. Effects of prednisone and β-aescinate sodium on functional recovery and electromyography in patients with acute facial neuritis[J]. World Clinical Drug, 2022, 43(4): 425-430, 448. https://www.cnki.com.cn/Article/CJFDTOTAL-GWHH202204011.htm
    [18]
    赵紫楠, 赵飞, 李婷, 等. 注射用七叶皂苷钠的药品临床综合评价[J]. 中国医院用药评价与分析, 2022, 22(9): 1109-1113. https://www.cnki.com.cn/Article/CJFDTOTAL-YYPF202209020.htm

    ZHAO Z N, ZHAO F, LI T, et al. Comprehensive Clinical Evaluation of Sodium Aescinate for Injection[J]. Evaluation and Analysis of Drug-use in Hospitals of China, 2022, 22(9): 1109-1113. https://www.cnki.com.cn/Article/CJFDTOTAL-YYPF202209020.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (120) PDF downloads(12) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return