Volume 22 Issue 4
Apr.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(4): 589-591
CAO Jiang, ZHANG Yan, YUAN Nahua, ZHU Guidong. Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression[J]. Chinese Journal of General Practice, 2024, 22(4): 589-591. doi: 10.16766/j.cnki.issn.1674-4152.003457
Citation: CAO Jiang, ZHANG Yan, YUAN Nahua, ZHU Guidong. Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression[J]. Chinese Journal of General Practice, 2024, 22(4): 589-591. doi: 10.16766/j.cnki.issn.1674-4152.003457
shu

Effects of transcranial direct current stimulation on therapeutic effect and cognitive function in patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.003457

  • The Sixth Ward of the Second People's Hospital of Lishui, Lishui, Zhejiang 323000, China

Funds:

 LGF22H090055

  • Received Date: 2023-12-27
    Available Online: 2024-05-29
    Abstract
  •   Objective  To investigate the therapeutic effect of transcranial direct current stimulation (tDCS) on patients with depression, and to observe its influence on the patients' cognitive function in order to provide a reference for the clinical application of tDCS in the treatment of depression.  Methods  A total of 112 patients with depression admitted to the Second People's Hospital of Lishui from March to December 2023 were selected as observation objects, and divided into control group (n=55) and tDCS group (n=57) according to whether they were treated with tDCS or not. The 17-item Hamilton depression scale (HAMD-17) score, Wisconsin card sorting test (WCST) score, and adverse reactions were compared between the two groups.  Results  After treatment, the overall efficacy rate of the tDCS group was higher than that of the control group [89.47% (51/57) vs. 69.09% (38/55), P < 0.01]. Before treatment, there was no significant difference in HAMD-17 score and WCST score between the two groups (P>0.05). After treatment, the HAMD-17 scores of both groups were significantly decreased (P < 0.05). After 4 weeks of treatment, the HAMD-17 score of the tDCS group was lower than that of the control group [(10.64±2.57) points vs. (15.82±2.96) points]. After 4 weeks of treatment, the 5-item WCST scores of the tDCS group were better than those of the control group (P < 0.001), and the patients' cognitive function was significantly improved. During treatment, adverse events occurred in both groups, including 1 case of nausea in the control group, 1 case of skin tingling, and 1 case of nausea in the tDCS group. There was no statistically significant difference in side effects between the two groups (P>0.05).  Conclusion  tDCS can effectively relieve the clinical symptoms of depression patients, the effect is obvious, and can improve the cognitive function of depression patients.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    MONROE S M, HARKNESS K L. Major depression and its recurrences: life course matters[J]. Annu Rev Clin Psychol, 2022, 18: 329-357. doi: 10.1146/annurev-clinpsy-072220-021440
    [2]
    邓杰, 何建波, 汪雨婷, 等. 青少年首发未治疗抑郁症患者脑灰质体积改变[J]. 中国医学影像技术, 2023, 39(1): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXX202301004.htm

    DENG J, HE J B, WANG Y T, et al. Changes of gray matter volume in adolescents with first-episode untreated depression[J]. Chinese Journal of Medical Imaging Technology, 2023, 39(1): 17-21. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXX202301004.htm
    [3]
    李鸿, 吕钦谕, 易正辉. 抑郁症合并焦虑症患者自杀态度调查及其与病情、应对方式的关系探讨[J]. 中华全科医学, 2019, 17(12): 2069-2071, 2134. doi: 10.16766/j.cnki.issn.1674-4152.001129

    LI H, LYU Q Y, YI Z H. Investigation of suicide attitudes and its relationship with illness conditions and coping styles in patients with depression combined with anxiety disorder[J]. Chinese Journal of General Practice, 2019, 17(12): 2069-2071, 2134. doi: 10.16766/j.cnki.issn.1674-4152.001129
    [4]
    REN J J, WU Z G, PENG D H, et al. Changes of anhedonia and cognitive symptoms in first episode of depression and recurrent depression, an analysis of data from NSSD[J]. J Affect Disord, 2023, 321: 47-55. doi: 10.1016/j.jad.2022.10.015
    [5]
    SCHILLING T M, BOSSERT M, WEISBROD M, et al. Cognitive impairments in patients with depression[J]. Nervenarzt, 2021, 92(3): 277-288. doi: 10.1007/s00115-021-01074-4
    [6]
    朱春燕, 胡希文, 菊轩, 等. 经颅直流电刺激联合伏硫西汀对快感缺失型抑郁症患者的疗效探究[J]. 中华全科医学, 2022, 20(9): 1477-1480. doi: 10.16766/j.cnki.issn.1674-4152.002627

    ZHU C Y, HU X W, JU X, et al. Effectiveness of Transcranial Direct Current Stimulation Therapy Combined with Vortioxetine for patients with anhedonia depression[J]. Chinese Journal of General Practice, 2022, 20(9): 1477-1480. doi: 10.16766/j.cnki.issn.1674-4152.002627
    [7]
    CHENG Y C, KUO P H, SU M I, et al. The efficacy of non-invasive, non-convulsive electrical neuromodulation on depression, anxiety and sleep disturbance: a systematic review and meta-analysis[J]. Psychol Med, 2022, 52(5): 801-812. doi: 10.1017/S0033291721005560
    [8]
    KIM W J, KIM H R, SONG J S, et al. Low levels of serum urate are associated with a higher prevalence of depression in older adults: a nationwide cross-sectional study in Korea[J]. Arthritis Res Ther, 2020, 22(1): 104. doi: 10.1186/s13075-020-02192-1
    [9]
    BRUNONI A R, VALIENGO L, ZANAO T, et al. Manic psychosis after sertraline and transcranial direct-current stimulation[J]. J Neuropsychiatry Clin Neurosci, 2011, 23(3): E4-5. DOI: 10.1176/jnp.23.3.jnpe4.
    [10]
    PARKER G, HADZI-PAVLOVIC D. Do hamilton depression scale items have the capacity to differentiate melancholic and non-melancholic depressive sub-types?[J]. J Affect Disord, 2020, 274: 1022-1027. doi: 10.1016/j.jad.2020.05.138
    [11]
    AUST S, BRAKEMEIER E L, SPIES J, et al. Efficacy of augmentation of cognitive behavioral therapy with transcranial direct current stimulation for depression: a randomized clinical trial[J]. JAMA Psychiatry, 2022, 79(6): 528-537. doi: 10.1001/jamapsychiatry.2022.0696
    [12]
    XU D, WANG Y L, WANG K T, et al. A scientometrics analysis and visualization of depressive disorder[J]. Curr Neuropharmacol, 2021, 19(6): 766-786. doi: 10.2174/1570159X18666200905151333
    [13]
    ZUMRAWI D, GLAZIER B L, LEONOVA O, et al. Subjective cognitive functioning, depressive symptoms, and objective cognitive functioning in people with treatment-resistant psychosis[J]. Cogn Neuropsychiatry, 2022, 27(6): 411-429. doi: 10.1080/13546805.2022.2108389
    [14]
    BARAKAT A, HAMDY M M, ELBADR M M. Uses of fluoxetine in nociceptive pain management: a literature overview[J]. Eur J Pharmacol, 2018, 829: 12-25. doi: 10.1016/j.ejphar.2018.03.042
    [15]
    段国平, 张旭, 汪洁, 等. 经颅直流电刺激在神经系统疾病康复中的应用现状[J]. 中国康复医学杂志, 2019, 34(9): 1106-1111. doi: 10.3969/j.issn.1001-1242.2019.09.022

    DUAN G P, ZHANG X, WANG J, et al. Application of transcranial direct current stimulation in rehabilitation of nervous system diseases[J]. Chinese Journal of Rehabilitation Medicine, 2019, 34(9): 1106-1111. doi: 10.3969/j.issn.1001-1242.2019.09.022
    [16]
    CHASE H W, BOUDEWYN M A, CARTER C S, et al. Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation[J]. Mol Psychiatry, 2020, 25(2): 397-407. doi: 10.1038/s41380-019-0499-9
    [17]
    邹建鹏, 毕鸿雁, 彭伟. 非侵入性脑刺激技术在神经系统疾病康复中的应用[J]. 中华全科医学, 2017, 15(11): 1948-1951. doi: 10.16766/j.cnki.issn.1674-4152.2017.11.038

    ZOU J P, BI H Y, PENG W. Application of non-invasive brain stimulation technique in rehabilitation of neurological diseases[J]. Chinese Journal of General Practice, 2017, 15(11): 1948-1951. doi: 10.16766/j.cnki.issn.1674-4152.2017.11.038
    [18]
    LIN Y Y, CHANG C C, HUANG C C, et al. Efficacy and neurophysiological predictors of treatment response of adjunct bifrontal transcranial direct current stimulation (tDCS) in treating unipolar and bipolar depression[J]. J Affect Disord, 2021, 280(Pt A): 295-304.
    [19]
    KENNEY D L, BLACKER C J, CAMSARI D D, et al. Transcranial direct current stimulation: mechanisms and psychiatric applications[J]. Child Adolesc Psychiatr Clin N Am, 2019, 28(1): 53-60. doi: 10.1016/j.chc.2018.07.008
    [20]
    JENKINS L M, STANGE J P, BESSETTE K L, et al. Differential engagement of cognitive control regions and subgenual cingulate based upon presence or absence of comorbid anxiety with depression[J]. J Affect Disord, 2018, 241: 371-380. doi: 10.1016/j.jad.2018.07.082
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (158) PDF downloads(14) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return