Analysis of curative effect of <i>Zishen Huoxue</i> Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

SUN Shuyun; YIN Yihong; YE Liqun

doi:10.16766/j.cnki.issn.1674-4152.003547

Volume 22 Issue 6

Jun. 2024

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SUN Shuyun, YIN Yihong, YE Liqun. Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve[J]. Chinese Journal of General Practice, 2024, 22(6): 975-978. doi: 10.16766/j.cnki.issn.1674-4152.003547

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SUN Shuyun, YIN Yihong, YE Liqun. Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve[J]. Chinese Journal of General Practice, 2024, 22(6): 975-978. doi: 10.16766/j.cnki.issn.1674-4152.003547

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Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

doi: 10.16766/j.cnki.issn.1674-4152.003547

Department II of Gynecology, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang 315010, China

Funds:

GZY-ZJ-KJ-23090

2022J285

Received Date: 2023-11-16
Available Online: 2024-07-22

Abstract

Abstract

Objective To observe and analyze the clinical efficacy of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve, and its effect on ovarian function and ovarian blood flow, providing a basis for clinical treatment. Methods A total of 750 patients with diminished ovarian reserve (kidney deficiency and blood stasis type) admitted to Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM) from July 2022 to November 2023 were selected as the study subjects, and the included patients were divided into group A (treated with Zishen Huoxue Decoction), group B (treated with estradiol valerate tablets combined with dydrogesterone tablets), and group C (treated with Zishen Huoxue Decoction + estradiol valerate tablets combined with dydrogesterone tablets) using the random number table method, with 250 patients in each group. Treatment effects, changes in follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume (OV), and ovarian stromal flow index before and after treatment were compared among the three groups of patients. Results The total effective rates of group A, group B, and group C were 82.0% (205/250), 64.4% (161/250), and 90.8% (227/250), respectively, and the total effective rates of group C were all higher than those of group B and A, and the total effective rate of group A was higher than that of group B (P < 0.05). After treatment, FSH and LH decreased more significantly in group C than in groups A and B, and FSH and LH decreased more significantly in group A than in group B (P < 0.05). AMH rose more significantly in group C than in groups A and B, and AMH rose more significantly in group A than in group B (P < 0.05). AFC and OV rose more significantly in group C than in groups A and B after treatment, and AFC and OV rose more significantly in group A than in group B (P < 0.05). PSV, VI, and FI rose were more significantly in group C than in groups A and B after treatment, and VI levels rose was more significantly in group A than in group B (P < 0.05). Conclusion Zishen Huoxue Decoction can effectively regulate ovarian function and improve ovarian blood supply in patients with kidney deficiency and blood stasis type of diminished ovarian reserve, with remarkable clinical efficacy, and is worth applying in clinical practice.
- Diminished ovarian reserve,
- Kidney deficiency and blood stasis type,
- Zishen Huoxue Decoction,
- Ovarian blood flow

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Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

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Analysis of curative effect of Zishen Huoxue Decoction in treating kidney deficiency and blood stasis type of diminished ovarian reserve

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