Volume 22 Issue 6
Jun.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(6): 1028-1032
ZENG Ge, LONG Jun, JIANG Junjie, CAI Hui, LI Qiaofeng. Predictive value of micro-blood flow imaging in the response of patients with rheumatoid arthritis to lguratimod therapy[J]. Chinese Journal of General Practice, 2024, 22(6): 1028-1032. doi: 10.16766/j.cnki.issn.1674-4152.003559
Citation: ZENG Ge, LONG Jun, JIANG Junjie, CAI Hui, LI Qiaofeng. Predictive value of micro-blood flow imaging in the response of patients with rheumatoid arthritis to lguratimod therapy[J]. Chinese Journal of General Practice, 2024, 22(6): 1028-1032. doi: 10.16766/j.cnki.issn.1674-4152.003559
shu

Predictive value of micro-blood flow imaging in the response of patients with rheumatoid arthritis to lguratimod therapy

doi: 10.16766/j.cnki.issn.1674-4152.003559

  • Department of Special Inspection Department, Huzhou Third Municipal Hospital, Wenzhou, Zhejiang 313000, China

Funds:

 2021KY1098

  • Received Date: 2023-12-15
    Available Online: 2024-07-22
    Abstract
  •   Objective  The response of patients with rheumatoid arthritis (RA) to Elamod therapy is significantly related to their prognosis. It is of great significance to identify patients who do not respond to treatment with Elamod at an early stage and adjust the treatment plan in time. Based on this, this study applied micro-blood flow imaging technology to the patients with RA treated by Elamod, and discussed its predictive value for the curative effect of Erasmus in the treatment of RA patients.  Methods  A total of 139 patients with RA who received Elamod in the Huzhou Third Municipal Hospital from January 2022 to January 2023 were divided into response group (n=88) and non-response group (n=51) according to their treatment response. The data of micro-blood flow imaging before treatment were collected, and the factors influencing non-response to RA Elamod treatment were screened by multivariate logistic regression, and a prediction model was constructed to analyze the predictive value of the model.  Results  Multivariate logistic regression analysis showed that high arterial resistance index (OR=0.362), blood flow grade 0 (OR=0.440), grade Ⅰ (OR=0.314), and grade Ⅱ (OR=0.120) were the protective factors for the non-response of RA' Elamod (P < 0.05). High ESR (OR=1.117), high DAS score (OR=1.367), and long-term morning stiffness (OR=1.159) were the risk factors (P < 0.05). Based on the prediction model of the above five indexes, the C-index and AUC of RA patients who did not respond to Elamod treatment were 0.816 and 0.816 (95% CI: 0.808-0.938), respectively.  Conclusion  Pulse resistance index, blood flow classification, ESR, DAS score, and morning stiffness time are the factors influencing treatment response of patients with RA, and the prediction model on them can be used to predict the risk of non-response of RA patients to treatment.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    RADU A F, BUNGAU S G. Management of rheumatoid arthritis: an overview[J]. Cells, 2021, 10(11): 2857. DOI: 10.3390/cells10112857.
    [2]
    何伟珍, 张会昌, 莫入, 等. 艾拉莫德联合昆仙胶囊治疗难治性狼疮性肾炎一例[J]. 新医学, 2020, 51(1): 71-73. doi: 10.3969/j.issn.0253-9802.2020.01.016

    HE W Z, ZHANG H C, MO R, et al. Iguratimod combined with Kunxian capsule in treatment of refractory lupus nephritis: a case report[J]. Journal of New Medicine, 2020, 51(1): 71-73. doi: 10.3969/j.issn.0253-9802.2020.01.016
    [3]
    许海艳, 况南珍, 张瑜娟, 等. 类风湿性关节炎治疗方法的研究进展[J]. 南昌大学学报(医学版), 2020, 60(5): 97-102.

    XU H Y, KUANG N Z, ZHANG Y J, et al. Research Progress in Treatment of Rheumatoid Arthritis[J]. Journal of Nanchang University (Medical Edition), 2020, 60(5): 97-102.
    [4]
    XIE S, LI S, TIAN J, et al. Iguratimod as a new drug for rheumatoid arthritis: current landscape[J]. Front Pharmacol, 2020, 11(1): 73. DOI: 10.3389/fphar.2020.00073.
    [5]
    NOZAKI Y, ORIBE M, TOMITA D, et al. Iguratimod versus salazosulfapyridine in rheumatoid arthritis patients with an inadequate response to methotrexate: adjusted with propensity score matching[J]. Mod Rheumatol, 2023, 33(3): 472-480. doi: 10.1093/mr/roac060
    [6]
    DENG L, YAO F, TIAN F, et al. Influence of iguratimod on bone metabolism in patients with rheumatoid arthritis: a meta-analysis[J]. Int J Clin Pract, 2022, 2022(1): 5684293. DOI: 10.1155/2022/5684293.
    [7]
    中华医学会风湿病学分会. 2018中国类风湿关节炎诊疗指南[J]. 临床医学研究与实践, 2018, 3(12): 242-251.

    Rheumatology Branch of Chinese Medical Association. 2018 Chinese guideline for the diagnosis and treatment of rheumatoid arthritis[J]. Chin J Intern Med, 2018, 3(12): 242-251.
    [8]
    MEZNERICS F A, KEMÉNY L V, GUNTHER E, et al. Multibiomarker disease activity score: an objective tool for monitoring rheumatoid arthritis? A systematic review and meta-analysis[J]. Rheumatology(Oxford), 2023, 62(6): 2048-2059. doi: 10.1093/rheumatology/keac715
    [9]
    FRAENKEL L, BATHON J M, ENGLAND B R, et al. 2021 American College of Rheumatology Guideline for the treatment of rheumatoid arthritis[J]. Arthritis Rheumatol, 2021, 73(7): 1108-1123. doi: 10.1002/art.41752
    [10]
    LIN Y J, ANZAGHE M, SCHVLKE S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis[J]. Cells, 2020, 9(4): 880. DOI: 10.3390/cells9040880.
    [11]
    CHAKRABORTY D, GUPTA K, BISWAS S. A mechanistic insight of phytoestrogens used for rheumatoid arthritis: an evidence-based review[J]. Biomed Pharmacother, 2021, 133(1): 111039. DOI: 10.1016/j.biopha.2020.111039.
    [12]
    NOZAKI Y. Iguratimod: novel molecular insights and a new csDMARD for rheumatoid arthritis, from Japan to the world[J]. Life(Basel), 2021, 11(5): 457. DOI: 10.3390/life11050457.
    [13]
    MATSUO H, IMAMURA A, SHIMIZU M, et al. Prediction of recurrence and remission using superb microvascular imaging in rheumatoid arthritis[J]. J Med Ultrason(2001), 2020, 47(1): 131-138. doi: 10.1007/s10396-019-00978-8
    [14]
    CUSH J J. Rheumatoid arthritis: early diagnosis and treatment[J]. Rheum Dis Clin North Am, 2022, 48(2): 537-547. doi: 10.1016/j.rdc.2022.02.010
    [15]
    DIAO X H, SHEN Y, CHEN L, et al. Superb microvascular imaging is as sensitive as contrast-enhanced ultrasound for detecting synovial vascularity in rheumatoid arthritis[J]. Quant Imaging Med Surg, 2022, 12(5): 2866-2876. doi: 10.21037/qims-21-859
    [16]
    SESKUTE G, DAPKUTE A, KAUSAITE D, et al. Multidisciplinary diagnostic dilemma in differentiating Madelung' s disease-the value of superb microvascular imaging technique: a case report[J]. World J Clin Cases, 2021, 9(21): 6145-6154. doi: 10.12998/wjcc.v9.i21.6145
    [17]
    TANG K, LIU M, ZHU Y, et al. The clinical application of ultrasonography with superb microvascular imaging-a review[J]. J Clin Ultrasound, 2022, 50(5): 721-732. doi: 10.1002/jcu.23210
    [18]
    李雪兰, 杨萌, 赵辰阳, 等. 超微血流成像在类风湿关节炎滑膜血流评估中的应用[J]. 中华医学超声杂志(电子版), 2023, 20(2): 232-237.

    LI X L, YANG M, ZHAO C Y, et al. Ultramicroangiography for evaluation of synovial blood flow in rheumatoid arthritis patients[J]. Chinese Journal of Medical Ultrasound(Electronic Edition), 2023, 20(2): 232-237.
    [19]
    MATSUO H, KAMADA M, IMAMURA A, et al. Machine learning-based prediction of relapse in rheumatoid arthritis patients using data on ultrasound examination and blood test[J]. Sci Rep, 2022, 12(1): 7224. DOI: 10.1038/s41598-022-11361-y.
    [20]
    SESKUTE G, JASOINYTE G, RUGIENE R, et al. The use of superb microvascular imaging in evaluating rheumatic diseases: a systematic review[J]. Medicina(Kaunas), 2023, 59(9): 1641. DOI: 10.3390/medicina59091641.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(4)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (68) PDF downloads(3) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return