Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1162-1165
XU Xingcheng, XU Li, ZHU Huaxia, GUO Kaiqi, MA Peiqi, WANG Zhongqiu, LI Xiaowei. Value of MR R2* measurement of liver iron concentration for assessing iron metabolism in patients with maintenance dialysis[J]. Chinese Journal of General Practice, 2024, 22(7): 1162-1165. doi: 10.16766/j.cnki.issn.1674-4152.003590
Citation: XU Xingcheng, XU Li, ZHU Huaxia, GUO Kaiqi, MA Peiqi, WANG Zhongqiu, LI Xiaowei. Value of MR R2* measurement of liver iron concentration for assessing iron metabolism in patients with maintenance dialysis[J]. Chinese Journal of General Practice, 2024, 22(7): 1162-1165. doi: 10.16766/j.cnki.issn.1674-4152.003590
shu

Value of MR R2* measurement of liver iron concentration for assessing iron metabolism in patients with maintenance dialysis

doi: 10.16766/j.cnki.issn.1674-4152.003590
  • 1.

    Department of Nephrology, Fuyang People ' s Hospital of Anhui Medical University, Fuyang, Anhui 236000, China

Funds:

 2022e07020057

 2020-04

 FK202081049

  • Received Date: 2023-10-10
    Available Online: 2024-09-05
    Abstract
  •   Objective  To evaluate the iron metabolism status of patients with chronic kidney disease undergoing dialysis by quantifying liver iron content using magnetic resonance R2* imaging and to compare it with conventional serological assessment methods, thereby assessing the utility of the magnetic resonance R2* method.  Methods  A cohort of 39 patients with chronic kidney disease undergoing dialysis, who visited Fuyang People ' s Hospital of Anhui Medical University between January 2021 and June 2023, was included. Magnetic resonance imaging was utilized to measure liver R2* values and calculate liver iron concentration (LIC). Correlation analyses were conducted between LIC and traditional iron metabolism indicators such as ferritin and transferrin saturation to assess the role of LIC in iron metabolism evaluation.  Results  Among the 39 follow-up visits of patients with chronic kidney disease undergoing dialysis, 23 cases (59.0%) were classified into the LIC deficiency group. Compared to the non-LIC deficiency group, the LIC deficiency group exhibited lower liver R2*, ferritin, while total iron binding capacity, transferrin, and hemoglobin levels were higher (P < 0.05). LIC demonstrated a positive correlation with ferritin, and red blood cell distribution width, and negative correlations with total iron binding capacity, transferrin (r values of 0.505, 0.394, -0.392, -0.415, all P < 0.05). A significant difference was observed between the LIC grouping criteria and traditional serological grouping criteria (P < 0.05). According to the 2021 Chinese Clinical Practice Guidelines for the Diagnosis and Treatment of Anemia in Renal Disease, among the 23 cases in the LIC deficiency group, 15 cases (65.2%) did not have absolute iron deficiency, whereas among the 16 cases in the non-LIC deficiency group, 3 cases (18.8%) had absolute iron deficiency.  Conclusion  The magnetic resonance R2* method for measuring LIC provides insight into the iron storage of patients with chronic kidney disease undergoing dialysis, and when combined with indicators such as ferritin and transferrin saturation, it may enhance the assessment of iron metabolism in these patients.

     

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