Volume 22 Issue 7
Jul.  2024
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1183-1187
PEI Qianqian, GAO Yun, WANG Chunmei. Diagnostic value of neutrophil-to-lymphocyte ratio in elderly patients with community-acquired urinary tract infection[J]. Chinese Journal of General Practice, 2024, 22(7): 1183-1187. doi: 10.16766/j.cnki.issn.1674-4152.003595
Citation: PEI Qianqian, GAO Yun, WANG Chunmei. Diagnostic value of neutrophil-to-lymphocyte ratio in elderly patients with community-acquired urinary tract infection[J]. Chinese Journal of General Practice, 2024, 22(7): 1183-1187. doi: 10.16766/j.cnki.issn.1674-4152.003595
shu

Diagnostic value of neutrophil-to-lymphocyte ratio in elderly patients with community-acquired urinary tract infection

doi: 10.16766/j.cnki.issn.1674-4152.003595
  • 1.

    Department of General Practice, Aerospace Center Hospital, Beijing 100049, China

Funds:

 2020YFC2005403

 2020YFC2005406

 21QK08

  • Received Date: 2023-09-07
    Available Online: 2024-09-05
    Abstract
  •   Objective   To investigate the value of the neutrophil to lymphocyte ratio (NLR) in the diagnosis of community-acquired urinary tract infection in the elderly.   Methods   A total of 159 elderly patients with community-acquired urinary tract infection (infection group) were selected from Xuanwu Hospital of Capital Medical University from January 2012 to December 2022. According to whether they progressed to bloodstream infection, they were divided into uro-derived bloodstream infection group (28 cases) and non-bloodstream infection group (131 cases). A total of 172 inpatients were matched for non-infectious diseases during the same period (non-infected group). ROC curve was used to analyze the clinical diagnostic value of NLR in community acquired urinary tract infection.   Results   The AUC of NLR was 0.729, and the optimal threshold, sensitivity and specificity were 3.5, 60% and 84%, respectively. The AUC of the non-bloodstream infection group was 0.684, and the optimal threshold, sensitivity and specificity were 3.7, 47% and 90%, respectively. The AUC of NLR in the diagnosis of community-acquired urinary tract infection in the elderly was 0.935, and the optimal threshold, sensitivity and specificity were 6.0, 86% and 99%, respectively.   Conclusion   (1) NLR has diagnostic value for community-acquired urinary tract infection in elderly people. When NLR≥6.0, the patient should be vigilant of progressing to bloodstream infection according to clinical manifestations and be referred to superior hospital in time. (2) The main pathogens of urinary tract infection are gram-negative bacteria, the most common of which is Escherichia coli. Therefore, early intervention can be performed according to the distribution characteristics of the pathogens.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    RODRIGUEZ-MAÑAS L. Urinary tract infections in the elderly: a review of disease characteristics and current treatment options[J]. Drugs Context, 2020. DOI: 10.7573/dic.2020-4-13.
    [2]
    SEIFU W D, GEBISSA A D. Prevalence and antibiotic susceptibility of Uropathogens from cases of urinary tract infections (UTI) in Shashemene referral hospital, Ethiopia[J]. BMC Infect Dis, 2018, 18(1): 30. DOI: 10.1186/s12879-017-2911-x.
    [3]
    Public Health England. Diagnosis of urinary tract infections. Quick reference tool for primary care for consultation and local adaptation[J]. PHE, 2018. DOI: 10.54097/ehss.v2i.829.
    [4]
    SMITHSON A, RAMOS J, NIÑO E, et al. Characteristics of febrile urinary tract infections in older male adults[J]. BMC Geriatr, 2019, 19(1): 334. DOI: 10.1186/s12877-019-1360-3.
    [5]
    WOJNO K J, BAUNOCH D, LUKE N, et al. Multiplex PCR based urinary tract infection (UTI) analysis compared to traditional urine culture in identifying significant pathogens in symptomatic patients[J]. Urology, 2020, 136: 119-126. doi: 10.1016/j.urology.2019.10.018
    [6]
    赵莹. 尿干化学法联合尿沉渣法用于尿液检验的临床效果观察[J]. 中国基层医药, 2020, 27(7): 776-780. doi: 10.3760/cma.j.issn.1008-6706.2020.07.003

    ZHAO Y. Clinical observation on combined use of dry chemical method and urinary sediment in routine urine examination[J]. Chinese Journal of Primary Medicine and Pharmacy, 2020, 27(7): 776-780. doi: 10.3760/cma.j.issn.1008-6706.2020.07.003
    [7]
    EL-GAZZAR A G, KAMEL M H, ELBAHNASY O K M, et al. Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients[J]. Expert Rev Respir Med, 2020, 14(1): 111-116. doi: 10.1080/17476348.2019.1675517
    [8]
    DRǍGOESCU A N, PǍDUREANU V, STǍNCULESCU A D, et al. Neutrophil to lymphocyte ratio (NLR): a useful tool for the prognosis of sepsis in the ICU[J]. Biomedicines, 2021, 10(1): 75. DOI: 10.3390/biomedicines10010075.
    [9]
    GAMEIRO J, FONSECA J A, JORGE S, et al. Neutrophil, lymphocyte and platelet ratio as a predictor of mortality in septic-acute kidney injury patients[J]. Nefrologia, 2020, 40(4): 461-468. doi: 10.1016/j.nefro.2019.11.006
    [10]
    钱少环, 李妙男, 姚卓亚, 等. 中性粒细胞与淋巴细胞比值联合C反应蛋白对急性冠脉综合征患者预后的预测价值[J]. 中华全科医学, 2020, 18(10): 1621-1624, 1628. doi: 10.16766/j.cnki.issn.1674-4152.001576

    QIAN S H, LI M N, YANG Z Y, et al. Prognostic value of neutrophil to lymphocyte ratio combined with C-reactive protein in patients with acute coronary syndrome[J]. Chinese Journal of General Practice, 2020, 18(10): 1621-1624, 1628. doi: 10.16766/j.cnki.issn.1674-4152.001576
    [11]
    陶涛, 何玲玲, 张业敏. 血常规中相关指标与急性脑梗死诊断及严重程度的相关性分析[J]. 中华全科医学, 2021, 19(10): 1717-1720, 1783. doi: 10.16766/j.cnki.issn.1674-4152.002150

    TAO T, HE L L, ZHANG Y M. Association of related markers in blood routine examination with diagnosis and severity of acute cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(10): 1717-1720, 1783. doi: 10.16766/j.cnki.issn.1674-4152.002150
    [12]
    CHO J H, CHO H J, LEE H Y, et al. Neutrophil-lymphocyte ratio in patients with acute heart failure predicts in-hospital and long-term mortality[J]. J Clin Med, 2020, 9(2): 557. DOI: 10.3390/jcm9020557.
    [13]
    YANG X, CHEN H, ZHENG Y, et al. Disease burden and long-term trends of urinary tract infections: a worldwide report[J]. Front Public Health, 2022, 10: 888205. DOI: 10.3389/fpubh.2022.888205.
    [14]
    杨直, 高静, 柏丁兮, 等. 老年慢性病共病患者治疗负担体验的质性研究[J]. 中国全科医学, 2022, 25(19): 2336-2341. doi: 10.12114/j.issn.1007-9572.2022.0169

    YANG Z, GAO J, BAI D X, et al. Experience of treatment burden in older adults with multimorbidity: a qualitative study[J]. Chinese General Practice, 2022, 25(19): 2336-2341. doi: 10.12114/j.issn.1007-9572.2022.0169
    [15]
    SONG M, GRAUBARD B I, RABKIN C S, et al. Neutrophil-to-lymphocyte ratio and mortality in the United States general population[J]. Sci Rep, 2021, 11(1): 464. DOI: 10.1038/s41598-020-79431-7.
    [16]
    胡蛟龙, 李晓红, 古勋清, 等. 中性粒细胞与淋巴细胞比值诊断尿路感染及尿源性脓毒症价值的研究[J]. 四川生理科学杂志, 2021, 43(7): 1116-1119.

    HU J L, LI X H, GU X Q, et al. Diagnostic role of neutrophil to lymphocyte ratio in tract infection and urinary sepsis[J]. Sichuan Journal of Physiological Sciences, 2021, 43(7): 1116-1119.
    [17]
    LEE W J, WOO S H, KIM D H, et al. The neutrophil-to-lymphocyte ratio is associated with bacteremia in older adults visiting the emergency department with urinary tract infections[J]. Aging Clin Exp Res, 2020, 32(6): 1129-1135. doi: 10.1007/s40520-019-01291-7
    [18]
    KLEIN R D, HULTGREN S J. Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies[J]. Nat Rev Microbiol, 2020, 18(4): 211-226. doi: 10.1038/s41579-020-0324-0
    [19]
    徐佳丽, 潘峰. 尿路感染的病原菌分布及耐药性分析[J]. 中国卫生检验杂志, 2020, 30(6): 713-715. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ202006022.htm

    XU J L, PAN F. Distribution and drug resistance of pathogens in urinary tract infection[J]. Chinese Journal of Health Laboratory Technology, 2020, 30(6): 713-715. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ202006022.htm
    [20]
    张苗苗, 郝小康, 周军, 等. 社区获得性血流感染患者病原菌分布及耐药性分析[J]. 河北医药, 2022, 44(16): 2542-2545. doi: 10.3969/j.issn.1002-7386.2022.16.035

    ZHANG M M, HAO X K, ZHOU J, et al. Distribution of pathogens and drug resistance in patients with community-acquired bloodstream infection[J]. Hebei Medical Journal, 2022, 44(16): 2542-2545. doi: 10.3969/j.issn.1002-7386.2022.16.035
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(6)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (50) PDF downloads(4) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return