Study on the treatment of primary osteoporosis of liver and kidney deficiency type with <i>Bugan Qiangshen Zhuanggu</i> Formula

YANG Jun; FAN Xu

doi:10.16766/j.cnki.issn.1674-4152.003596

Volume 22 Issue 7

Jul. 2024

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YANG Jun, FAN Xu. Study on the treatment of primary osteoporosis of liver and kidney deficiency type with Bugan Qiangshen Zhuanggu Formula[J]. Chinese Journal of General Practice, 2024, 22(7): 1188-1191. doi: 10.16766/j.cnki.issn.1674-4152.003596

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YANG Jun, FAN Xu. Study on the treatment of primary osteoporosis of liver and kidney deficiency type with Bugan Qiangshen Zhuanggu Formula[J]. Chinese Journal of General Practice, 2024, 22(7): 1188-1191. doi: 10.16766/j.cnki.issn.1674-4152.003596

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Study on the treatment of primary osteoporosis of liver and kidney deficiency type with Bugan Qiangshen Zhuanggu Formula

doi: 10.16766/j.cnki.issn.1674-4152.003596

YANG Jun^,
, FAN Xu

Department of Orthopedics, Tiantai County People ' s Hospital, Taizhou, Zhejiang 317200, China

Funds:

2023ZL201

Received Date: 2024-03-18
Available Online: 2024-09-05

Abstract

Abstract

Objective To explore the clinical effect of Bugan Qiangshen Zhuanggu Formula in treating primary osteoporosis (liver and kidney deficiency type). Methods A total of 130 patients with primary osteoporosis (liver and kidney deficiency type) admitted to Tiantai County People ' s Hospital from April 2020 to October 2023 were studied, and were divided into control group (65 cases) and observation group (65 cases) randomly. The control group were given alendronate sodium tablets and calcium carbonate D₃ tablets, while the observation group received additional treatment with Bugan Qiangshen Zhuanggu Formula. The therapeutic effect level of traditional Chinese medicine syndrome in patients were evaluated, the changes in bone density and serum bone metabolism indicators were detected, the differences in VAS score and SF-36 score were compared, and the adverse drug reactions were observed. Results The overall effective rate of traditional Chinese medicine syndromes in observation group (93.85%, 61/65) was higher than control group (69.23%, 45/65, P < 0.001). After 12 weeks of treatment, the bone density values of the lumbar spine L_2-4, right femoral neck, and left distal radius in the observation group were higher than the control group (P < 0.001). The VAS score of observation group (2.47±0.63) was lower than control group (3.29±0.72, P < 0.001), while the SF-36 score (85.73±6.49) was higher than control group (74.65±6.27, P < 0.001). The levels of serum bone-specific alkaline phosphatase (BALP) and type Ⅰ procollagen amino terminal peptide (P1NP) in observation group was higher than control group, but the levels of serum cross-linked type 1 collagen C-terminal peptide (CTX) and N-telopeptide of type Ⅰ collagen (NTX) were lower than control group (P < 0.001). The incidence of adverse reactions between the two groups was no difference (P>0.05). Conclusion Bugan Qiangshen Zhuanggu Formula combined with alendronate sodium and calcium carbonate D₃ can effectively improve traditional Chinese medicine symptoms, alleviate pain reactions, and improve quality of life in patients with primary osteoporosis of liver and kidney deficiency type. Its mechanism of action is closely related to enhancing patient bone density and regulating bone metabolism function.
- Primary osteoporosis,
- Liver and kidney deficiency type,
- Bugan Qiangshen Zhuanggu Formula,
- Alendronate sodium,
- Calcium carbonate D₃,
- Clinical efficacy

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References(23)

References

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Study on the treatment of primary osteoporosis of liver and kidney deficiency type with Bugan Qiangshen Zhuanggu Formula

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Study on the treatment of primary osteoporosis of liver and kidney deficiency type with Bugan Qiangshen Zhuanggu Formula

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