Volume 22 Issue 7
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1217-1221
LI Xianhong, ZHANG Jian. Research progress of amplitude-integrated electroencephalography in neonatal brain function monitoring[J]. Chinese Journal of General Practice, 2024, 22(7): 1217-1221. doi: 10.16766/j.cnki.issn.1674-4152.003603
Citation: LI Xianhong, ZHANG Jian. Research progress of amplitude-integrated electroencephalography in neonatal brain function monitoring[J]. Chinese Journal of General Practice, 2024, 22(7): 1217-1221. doi: 10.16766/j.cnki.issn.1674-4152.003603
shu

Research progress of amplitude-integrated electroencephalography in neonatal brain function monitoring

doi: 10.16766/j.cnki.issn.1674-4152.003603

  • Department of Neonatology, Anhui Provincial Children's Hospital, Hefei, Anhui 230051, China

Funds:

 AHWJ2022b087

  • Received Date: 2023-10-10
    Available Online: 2024-09-05
    Abstract
  • Neonatal brain injury is a common neurological disorder in the newborn period, often associated with various factors such as perinatal asphyxia, hypoxic-ischemic events, hyperbilirubinemia, prematurity, and infections. The prognosis can range from early neurobehavioral abnormalities to various degrees of long-term neurodevelopmental disorders. Therefore, early and accurate identification of neonatal brain injury and timely intervention are crucial in preventing adverse neurodevelopmental outcomes. Brainwave monitoring is an important tool for diagnosing, evaluating, and predicting the prognosis of neonatal brain diseases. In recent years, amplitude-integrated electroencephalography (aEEG) as a non-invasive brain function monitoring tool has gradually been used in neonatal intensive care units. Compared to traditional electroencephalography, aEEG signal processing is simplified, focusing mainly on low-frequency waveforms in the spectrum. Its output typically displays as a continuous trend graph, making it easy for clinicians to observe and analyze. Therefore, aEEG is currently widely used for early brain function monitoring in neonatal brain injuries caused by birth asphyxia, hypoxic-ischemic encephalopathy, neonatal hyperbilirubinemia, neonatal seizures, and neonatal infections. Since aEEG can be initiated within a few hours after birth, it can promptly detect abnormal brainwave activity, demonstrating high sensitivity and specificity in the early diagnosis, evaluation, and prognosis prediction of neonatal brain injuries. With further research into aEEG in neonatal clinical settings, continuous improvement of aEEG technology, establishment of standardized aEEG monitoring procedures, and the integration of other brain structure or function assessment tools, will effectively enhance the diagnostic and prognostic value of neonatal brain injuries, enabling early detection of brain injuries and developmental abnormalities, and thereby improving outcomes through early intervention.

     

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  • [1]
    VARIANE G F T, RODRIGUES D P, PIETROBOM R F R, et al. Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography[J]. J Pediatr (Rio J), 2022, 98(6): 565-571.
    [2]
    中华医学会儿科学分会新生儿学组, 中国当代儿科杂志编辑委员会, 国家卫生健康委员会新生儿疾病重点实验室. 新生儿脑电生理监测分级管理专家共识[J]. 中国当代儿科杂志, 2022, 24(2): 115-123. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202202001.htm

    Subspecialty Group of Neonatology, Society of Pediatrics, Chinese Medical Association; Chinese Journal of Contemporary Pediatrics; National Health Commission Key Laboratory of Neonatal Diseases. Expert consensus on grading management of electroencephalogram monitoring in neonates[J]. Chinese Journal of Contemporary Pediatrics, 2022, 24(2): 115-123. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202202001.htm
    [3]
    CHALAK L, HELLSTROM-WESTAS L, BONIFACIO S, et al. Bedside and laboratory neuromonitoring in neonatal encephalopathy[J]. Semin Fetal Neonatal Med, 2021, 26(5): 101273. DOI: 10.1016/j.siny.2021.101273.
    [4]
    LEE I C, HONG S Y, WENG Y H, et al. Amplitude integrated electroencephalography and continuous electroencephalography monitoring is crucial in high-risk infants and their findings correlate with neurodevelopmental outcomes[J]. Front Pediatr, 2021, 9: 691764. DOI: 10.3389/fped.2021.691764.
    [5]
    SHARMA G K, NATARAJAN C K, HEMENTHAKUMAR V, et al. Prognostic value of amplitude-integrated electroencephalography in term neonates with encephalopathy[J]. Indian Pediatr, 2021, 58(10): 928-931.
    [6]
    鞠俊, 常贺生, 秦选光. 窒息新生儿窒息生后早期外周动脉血血气分析pH值与振幅整合脑功能的关系[J]. 临床和实验医学杂志, 2022, 21(11): 1204-1208. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202211023.htm

    JU J, CHANG H S, QIN X G. Relationship between pH value of peripheral arterial blood gas analysis and amplitude integration brain function in early postnatal asphyxia newborns[J]. Journal of Clinical and Experimental Medicine, 2022, 21(11): 1204-1208. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202211023.htm
    [7]
    陈健萍, 谭葵欢, 袁海超, 等. aEEG、脐血pH及新生儿Apgar评分对新生儿窒息结局的预测价值[J]. 海南医学, 2022, 33(3): 342-344. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202203017.htm

    CHEN J P, TAN K H, YUAN H C, et al. Predictive value of aEEG, cord blood pH and neonatal Apgar score for neonatal asphyxia outcome[J]. Hainan Medical Journal, 2022, 33(3): 342-344. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202203017.htm
    [8]
    李花, 钱向明, 韦红. 振幅整合脑电图对足月窒息新生儿缺氧缺血性脑病程度及预后的预测价值[J]. 中国医药, 2019, 14(11): 1652-1655. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG201911014.htm

    LI H, QIAN X M, WEI H. Predictive value of amplitude-integrated electroencephalogram for the severity and prognosis of hypoxic ischemic encephalopathy in full-term neonates with asphyxia[J]. China Medicine, 2019, 14(11): 1652-1655. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG201911014.htm
    [9]
    俞赟, 喻萍, 潘怡之, 等. 睡眠觉醒周期在足月窒息新生儿中的临床应用及在预后预测中的价值[J]. 吉林医学, 2022, 43(3): 641-645. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202203021.htm

    YU Y, YU P, PAN Y Z, et al. The clinical application of sleep-wake cycle in full-term neonates with asphyxia and the analysis of prognostic value[J]. Jilin Medical Journal, 2022, 43(3): 641-645. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202203021.htm
    [10]
    李兆杭, 梁玉美, 孟子达, 等. 改良aEEG评分联合血清NSE对新生儿缺氧缺血性脑病早期诊断价值的研究[J]. 右江民族医学院学报, 2022, 44(5): 713-718. https://www.cnki.com.cn/Article/CJFDTOTAL-YJMZ202205016.htm

    LI Z H, LIANG Y M, MENG Z D, et al. Study on the value of modified aEEG combined with serum NSE in early diagnosis of neonatal hypoxic-ischemic encephalopathy[J]. Journal of Youjiang Medical University for Nationalities, 2022, 44(5): 713-718. https://www.cnki.com.cn/Article/CJFDTOTAL-YJMZ202205016.htm
    [11]
    NYMAN J, MIKKONEN K, METSǍRANTA M, et al. Poor aEEG background recovery after perinatal hypoxic ischemic encephalopathy predicts postneonatal epilepsy by age 4 years[J]. Clin Neurophysiol, 2022, 143: 116-123.
    [12]
    MEDER U, CSEKO A J, SZAKACS L, et al. Longitudinal analysis of amplitude-integrated electroencephalography for outcome prediction in hypoxic-ischemic encephalopathy[J]. J Pediatr, 2022, 246: 19-25. e15. DOI: 10.1016/j.jpeds.2022.04.013.
    [13]
    TIAN Q Y, PAN Y Z, ZHANG Z, et al. Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE)[J]. BMC Pediatr, 2021, 21(1): 410. DOI: 10.1186/s12887-021-02796-9.
    [14]
    蒋林, 蔡芳. aEEG评估新生儿高胆红素血症脑损伤的临床价值探讨[J]. 吉林医学, 2020, 41(8): 1924-1926. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202008058.htm

    JIANG L, CAI F. Clinical value of aEEG in evaluating neonatal hyperbilirubinemia brain injury[J]. Jilin Medical Journal, 2020, 41(8): 1924-1926. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202008058.htm
    [15]
    唐娟, 王萍, 罗春华, 等. 振幅整合脑电图在严重高胆红素血症新生儿脑损伤中的监测意义[J]. 中华围产医学杂志, 2020, 23(10): 655-661. https://cdmd.cnki.com.cn/Article/CDMD-10161-1021108267.htm

    TANG J, WANG P, LUO C H, et al. Value of amplitude-integrated electroencephalography in neonates with brain injury due to severe hyperbilirubinemia[J]. Chinese Journal of Perinatal Medicine, 2020, 23(10): 655-661. https://cdmd.cnki.com.cn/Article/CDMD-10161-1021108267.htm
    [16]
    LU W N, YANG X Y, NING S Y, et al. Fully automated simultaneous peripheral arteriovenous exchange transfusion not seen to aggravate brain function and the disorder of the internal environment in neonates with severe hyperbilirubinemia[J]. Pediatr Neonatol, 2021, 62(3): 312-320.
    [17]
    吴丽燕, 邹友富, 郭梁, 等. 振幅整合脑电图在预判新生儿高胆红素血症不良预后中的价值研究[J]. 吉林医学, 2021, 42(2): 276-279. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202102006.htm

    WU L Y, ZOU Y F, GUO L, et al. The value of amplitude-integrated electroencephalogram to predicts long-term outcomes in term infant with severe hyperbilirubinemia[J]. Jilin Medical Journal, 2021, 42(2): 276-279. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX202102006.htm
    [18]
    刘春艳, 马巧梅, 师娟娟, 等. 振幅整合脑电图在新生儿惊厥中的应用价值[J]. 海南医学, 2021, 32(24): 3224-3226. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202124027.htm

    LIU C Y, MA Q M, SHI J J, et al. Application value of amplitude integrated electroencephalogram in neonatal convulsion[J]. Hainan Medical Journal, 2021, 32(24): 3224-3226. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIN202124027.htm
    [19]
    张彦华, 邢景月, 华敏敏, 等. 新生儿惊厥不良结局危险因素分析[J]. 中华新生儿科杂志(中英文), 2023, 38(4): 210-214. https://cdmd.cnki.com.cn/Article/CDMD-10422-1014124440.htm

    ZHANG Y H, XING J Y, HUA M M, et al. Clinical analysis of risk factors for adverse outcomes of neonatal seizure[J]. Chinese Journal of Neonatology, 2023, 38(4): 210-214. https://cdmd.cnki.com.cn/Article/CDMD-10422-1014124440.htm
    [20]
    DOANDES F M, MANEA A M, LUNGU N, et al. The role of amplitude-integrated electroencephalography (aEEG) in monitoring infants with neonatal seizures and predicting their neurodevelopmental outcome[J]. Children (Basel), 2023, 10(5): 883. DOI: 10.3390/children10050833.
    [21]
    SANDOVAL KARAMIAN A G, WUSTHOFF C J. How helpful is aEEG? Context and user experience matter[J]. Am J Perinatol, 2022, 39(10): 1132-1137.
    [22]
    王娟, 张粉霞, 袁强, 等. 振幅整合脑电图与视频脑电图对照分析在新生儿惊厥发作中的诊断价值[J]. 中国小儿急救医学, 2023, 30(3): 234-238. https://www.cnki.net/KCMS/detail/detail.aspx?dbcode=IPFD&filename=KDXX202110001118&dbname=IPFDLAST2023

    WANG J, ZHANG F X, YUAN Q, et al. Diagnostic value of amplitude integrated electroencephalogram and video electroencephalogram in neonatal seizures[J]. Chinese Pediatric Emergency Medicine, 2023, 30(3): 234-238. https://www.cnki.net/KCMS/detail/detail.aspx?dbcode=IPFD&filename=KDXX202110001118&dbname=IPFDLAST2023
    [23]
    中国抗癫痫协会脑电图与神经电生理分会新生儿脑电图学组. 新生儿振幅整合脑电图临床应用中国专家共识(2023)[J]. 中华新生儿科杂志(中英文), 2023, 38(3): 129-135.

    Subspecialty Group of Neonatal Electroencephalogram, Society of Electroencephalogram and Neurophysiology, China Association Against Epilepsy. Chinese expert consensus on clinical application of amplitude-integrated electroencephalography in neonates(2023)[J]. Chinese Journal of Neonatology, 2023, 38(3): 129-135.
    [24]
    RICHARDSON J, GOSHEN S, MELEDIN I, et al. Predictive value of early amplitude integrated EEG in extremely premature infants[J]. J Child Neurol, 2020, 35(11): 737-743.
    [25]
    田艺丽, 方秀英, 王英杰, 等. 一种新的早产儿脑电发育成熟度评价方法的初步研究[J]. 中国当代儿科杂志, 2023, 25(8): 805-811. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202308005.htm

    TIAN Y L, FANG X Y, WANG Y J, et al. A preliminary study on a new method for evaluating brain maturation in preterm infants[J]. Chinese Journal of Contemporary Pediatrics, 2023, 25(8): 805-811. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202308005.htm
    [26]
    SCHREINER C, HAMMERL M, NEUBAUER V, et al. Amplitude-integrated electroencephalography signals in preterm infants with cerebral hemorrhage[J]. Early Hum Dev, 2021, 154: 105309. DOI: 10.1016/j.earlhumdev.2021.105309.
    [27]
    CHEN S, XIAO X M, LIN S, et al. Early aEEG can predict neurodevelopmental outcomes at 12 to 18 month of age in VLBWI with necrotizing enterocolitis: a cohort study[J]. BMC Pediatr, 2021, 21(1): 582. DOI: 10.1186/s12887-021-03056-6.
    [28]
    黄会芝, 温晓红, 孙亚伟, 等. 振幅整合脑电图结合头颅MRI对窒息早产儿脑损伤的诊断及神经行为发育的预测[J]. 中华行为医学与脑科学杂志, 2021, 30(1): 22-26.

    HUANG H Z, WEN X H, SUN Y W, et al. Amplitude-integrated electroencephalogram combined with cranial magnetic resonance imaging for diagnosis of brain injury and prediction on neurobehavioral development in premature infants with asphyxiation[J]. Chinese Journal of Behavioral Medicine and Brain Science, 2021, 30(1): 22-26.
    [29]
    王卫卫, 张红伟, 李晓芳, 等. 振幅整合脑电图联合头颅磁共振成像对晚期早产儿神经行为发育异常的预测价值[J]. 新乡医学院学报, 2023, 40(6): 558-562, 568. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX202306012.htm

    WANG W W, ZHANG H W, LI X F, et al. Predictive value of amplitude-integrated electroencephalogram combined with cranial magnetic resonance imaging for neurobehavioral abnormalities of late preterm infants[J]. Journal of Xinxiang Medical University, 2023, 40(6): 558-562, 568. https://www.cnki.com.cn/Article/CJFDTOTAL-XXYX202306012.htm
    [30]
    周君, 赵晓芬, 杜琨, 等. 振幅整合脑电图对新生儿细菌性脑膜炎神经学预后的预测价值[J]. 中国小儿急救医学, 2022, 29(11): 875-879.

    ZHOU J, ZHAO X F, DU K, et al. Predictive value of amplitude integrated electroencephalography in neurological prognosis of neonatal bacterial meningitis[J]. Chinese Pediatric Emergency Medicine, 2022, 29(11): 875-879.
    [31]
    许钰枚. 探讨振幅整合脑电图联合脑脊液蛋白及酶学指标对新生儿化脓性脑膜炎的检测价值及临床指导意义[J]. 齐齐哈尔医学院学报, 2021, 42(22): 1946-1950. https://www.cnki.com.cn/Article/CJFDTOTAL-QQHB202122004.htm

    XU Y M. To explore the value of amplitude integrated electroencephalogram combined with cerebrospinal fluid proteinand enzymatic indicators in the detection of neonatal purulent meningitis and its clinical guiding significance[J]. Journal of Qiqihar Medical University, 2021, 42(22): 1946-1950. https://www.cnki.com.cn/Article/CJFDTOTAL-QQHB202122004.htm
    [32]
    接双双, 戴立英. 近红外光谱技术在危重新生儿的应用及研究进展[J]. 中华全科医学, 2021, 19(12): 2106-2109. doi: 10.16766/j.cnki.issn.1674-4152.002248

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