Volume 22 Issue 7
Jul.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(7): 1239-1245
ZHANG Qiang, DENG Weizhe, YI Shihua, SHAO Yingzi, WANG Zhenyu, LU Xiuyun. Efficacy and safety of Yiqi Yangyin Decoction in treating systemic lupus erythematosus: a meta-analysis[J]. Chinese Journal of General Practice, 2024, 22(7): 1239-1245. doi: 10.16766/j.cnki.issn.1674-4152.003608
Citation: ZHANG Qiang, DENG Weizhe, YI Shihua, SHAO Yingzi, WANG Zhenyu, LU Xiuyun. Efficacy and safety of Yiqi Yangyin Decoction in treating systemic lupus erythematosus: a meta-analysis[J]. Chinese Journal of General Practice, 2024, 22(7): 1239-1245. doi: 10.16766/j.cnki.issn.1674-4152.003608
shu

Efficacy and safety of Yiqi Yangyin Decoction in treating systemic lupus erythematosus: a meta-analysis

doi: 10.16766/j.cnki.issn.1674-4152.003608
  • 1.

    Rheumatology and Traditional Chinese Medicine Department, the 962nd Hospital of the PLA, Harbin, Heilongjiang 150048, China

Funds:

 20222121011102

 2023QY003

  • Received Date: 2024-01-09
    Available Online: 2024-09-05
    Abstract
  •   Objective  The application of classic Chinese medicine in rheumatic diseases has been a prominent research focus. Systemic lupus erythematosus (SLE) has a significant patient population in China. The efficacy of integrated Chinese and Western medicine in the treatment of SLE remains controversial. This study explores the effectiveness and safety of the Yiqi Yangyin Decoction in the treatment of systemic lupus erythematosus through meta-analysis.  Methods  A comprehensive search was conducted on multiple databases including PubMed, Medline, EMbase, Cochrane Library, Web of Science, CBM, Wangfang, CNKI, and VIP from the establishment of the database to November 26, 2023. The scope of the search was limited to randomized controlled trial studying the efficacy of Yiqi Yangyin Decoction in the treatment of SLE. The experimental group received Yiqi Yangyin Decoction in combination with Western medicine, while the control group received only Western medicine. The retrieved literature was filtered and managed using EndNote 20.0. Data extraction and quality evaluation were performed using RevMan 5.4. Sensitivity analysis and publication bias analysis were conducted using Stata 15.0.  Results  A total of 24 studies were conducted, including 1 051 patients in the experimental group and 940 patients in the control group. The experimental group showed a higher total effective rate compared to the control group (OR=4.35, 95% CI: 3.11-6.11). Additionally, the experimental group had a lower incidence of adverse reactions compared to the control group (OR=0.17, 95% CI: 0.11-0.26). These differences were statistically significant (P < 0.05). The experimental group showed better scores in traditional Chinese medicine syndrome, systemic lupus erythematosus disease activity index, ds-DNA negative conversion rate, complement3, 24 hour urinary protein quantity, and glucocorticoid maintenance dosage compared to the control group, with all differences being statistically significant (P < 0.05). The ANA negative conversion rate was slightly higher in the experimental group, but the difference was not statistically significant (P > 0.05).  Conclusion  The application of Yiqi Yangyin Decoction in the treatment of SLE can enhance clinical effectiveness, reduce the occurrence of adverse reactions, and yield positive outcomes across multiple aspects.

     

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