Volume 22 Issue 8
Aug.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(8): 1313-1316
YUAN Yongjin, TANG Jing, FAN Zhongmin, MA Zhenjie. Effect of sugammadex sodium and neostigmine on prognosis of patients with video-assisted thoracoscopic lobectomy[J]. Chinese Journal of General Practice, 2024, 22(8): 1313-1316. doi: 10.16766/j.cnki.issn.1674-4152.003624
Citation: YUAN Yongjin, TANG Jing, FAN Zhongmin, MA Zhenjie. Effect of sugammadex sodium and neostigmine on prognosis of patients with video-assisted thoracoscopic lobectomy[J]. Chinese Journal of General Practice, 2024, 22(8): 1313-1316. doi: 10.16766/j.cnki.issn.1674-4152.003624
shu

Effect of sugammadex sodium and neostigmine on prognosis of patients with video-assisted thoracoscopic lobectomy

doi: 10.16766/j.cnki.issn.1674-4152.003624
  • 1.

    Department of Anesthesiology, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, China

Funds:

 2021-wjzdx-59

 ASRF-2021-YB-03

  • Received Date: 2023-06-13
    Available Online: 2024-11-19
    Abstract
  •   Objective  Postoperative muscle relaxant residue can lead to respiratory insufficiency, the aim of this study was to evaluate the antagonistic effects of sugammadex sodium and neostigmine on the muscular release of rocuronium in patients undergoing video-assisted thoracoscopic lobectomy, as well as their impact on postoperative pulmonary complications.  Methods  A total of 90 patients who planned to undergo elective video-assisted thoracoscopic lobectomy in the Affiliated Hospital of Qinghai University from September 2021 to December 2022 were selected, and they were randomly assigned to either the sugammadex sodium group (group S) or neostigmine group (group N) using a random number table method, with 45 cases in each group. Group S was intravenously injected with sugammadex sodium 2 mg/kg, while Group N received an intravenous injection with neostigmine 0.05 mg/kg (maximum dose 5 mg) and atropine 0.02 mg/kg. Extubation time, post-anesthesia cave unit (PACU) stay time, postoperative length of hospitalization, and total length of hospitalization were compared. Muscle strength in each part of the patient was assessed 15 min after admission to PACU. Postoperative pulmonary infection and other adverse reactions were compared.  Results  The extubation time and PACU residence time in group S were 8.1 (6.1, 10.9) min, 11.8 (8.9, 19.7) min, respectively, which were statistically shorter than those in group N [8.6 (6.4, 16.5) min, 13.3 (10.0, 23.9) min], and the differences were statistically significant (Z=2.089, 2.853, P < 0.05). The number of patients in group S with head raising and holding was significantly higher than that in the N group (P < 0.05). The number of patients in group S who can track object with eyes was statistically higher than that in group N (P < 0.05). There was no significant difference in the incidence of postoperative adverse reactions between 2 groups (P>0.05).  Conclusion  Compared with neostigmine, sugammadex sodium antagonized the muscle relaxation effect of rocuronium in patients with video-assisted thoracoscopic lobectomy but did not reduce the risk of postoperative pulmonary complications.

     

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