Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery

WANG Xiaoyan; PAN Qin; HUANG Changjun; LI Yuhong

doi:10.16766/j.cnki.issn.1674-4152.003634

Volume 22 Issue 8

Aug. 2024

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WANG Xiaoyan, PAN Qin, HUANG Changjun, LI Yuhong. Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery[J]. Chinese Journal of General Practice, 2024, 22(8): 1350-1353. doi: 10.16766/j.cnki.issn.1674-4152.003634

Citation:

WANG Xiaoyan, PAN Qin, HUANG Changjun, LI Yuhong. Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery[J]. Chinese Journal of General Practice, 2024, 22(8): 1350-1353. doi: 10.16766/j.cnki.issn.1674-4152.003634

Citation:

WANG Xiaoyan, PAN Qin, HUANG Changjun, LI Yuhong. Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery[J]. Chinese Journal of General Practice, 2024, 22(8): 1350-1353. doi: 10.16766/j.cnki.issn.1674-4152.003634

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Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery

doi: 10.16766/j.cnki.issn.1674-4152.003634

1.
Department of Anesthesiology, the First People ' s Hospital of Linping District, Hangzhou, Zhejiang 311100, China

Funds:

2024KY270

Received Date: 2024-03-11
Available Online: 2024-11-19

Abstract

Abstract

Objective High-dose opioid analgesics can control severe pain after thoracic surgery, but can easily cause nausea, respiratory depression, and other side effects. In this study, erector spinae plane block (ESPB) was applied to thoracic surgery before operation to explore its influence on postoperative stress and opioid demand of patients. Methods From March 2021 to March 2023, 200 patients with lung cancer who underwent elective radical resection of lung cancer in the First People ' s Hospital of Linping District, Hangzhou were divided into a control group (pure intravenous anesthesia) and a compound group (ESPB combined intravenous general anesthesia) according to anesthesia methods, with 100 patients in each group. The indexes of oxidative stress, serum-related indexes, pain, and opioid use were compared between the two groups. Results Malondialdehyde (MDA) levels increased and super oxide dismutase (SOD) levels decreased 24 h after operation in lung cancer patients in both groups. Moreover, MDA and SOD levels in the compound group [(6.69±1.84) nmol/L, (37.30±6.42) U/mL] were lower than those in the control group [(9.03±1.35) nmol/L, (41.56±6.88) U/mL, P < 0.05]. At T1, T2, and T3, the levels of IL-6, Cor, and Ang-Ⅱ in the compound group were lower than those in the control group, and the levels of IL-10 were higher than those in the control group (P < 0.05). At T2, T3, and T4, the scores of resting and dynamic VAS in the compound group were lower than those in the control group (P < 0.05). The dosage of remifentanil in the compound group was (554.8±97.2) μg. The total amount of sufentanil infusion [(28.7±5.9) mL] and the number of supplementary infusion [(2.1±0.6) times] in 24 h were lower than those in the control group [(675.2±164.5) μg, (39.5±6.2) mL, (3.2±0.9) times, P < 0.05]. Conclusion The application of ESPB combined with intravenous general anesthesia in radical resection of lung cancer can improve stress and inflammatory reaction, and reduce postoperative pain and the demand for opioids. It is a feasible and superior anesthesia method.
- Erector spinae plane block,
- Sufentanil,
- Radical operation of lung cancer,
- Interleukin 6

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References

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Effect of preoperative erector spinae plane block on postoperative stress and opioid demand of patients undergoing thoracic surgery

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