Volume 22 Issue 8
Aug.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(8): 1381-1384
QIAN Guoying, CAI Lili, FEI Jinfeng, YANG Shengliang, ZHONG Hua. Efficacy of cognitive behavioral self-help therapy for depression disorder to withdraw from long-term benzodiazepine use[J]. Chinese Journal of General Practice, 2024, 22(8): 1381-1384. doi: 10.16766/j.cnki.issn.1674-4152.003641
Citation: QIAN Guoying, CAI Lili, FEI Jinfeng, YANG Shengliang, ZHONG Hua. Efficacy of cognitive behavioral self-help therapy for depression disorder to withdraw from long-term benzodiazepine use[J]. Chinese Journal of General Practice, 2024, 22(8): 1381-1384. doi: 10.16766/j.cnki.issn.1674-4152.003641
shu

Efficacy of cognitive behavioral self-help therapy for depression disorder to withdraw from long-term benzodiazepine use

doi: 10.16766/j.cnki.issn.1674-4152.003641

  • Department of Psychiatry, Huzhou Third Municipal Hospital, Huzhou, Zhejiang 313000, China

Funds:

 2020RC036

 2019GY07

  • Received Date: 2023-11-23
    Available Online: 2024-11-19
    Abstract
  •   Objective   To evaluate the efficacy and security of tapering off long-term benzodiazepine (BZD) use for depression disorder, and to evaluate the value of additional cognitive behavioral therapy-self help (CBT-SH).   Methods   An 8-week randomized controlled trial was conducted in which 80 patients with depression who returned to the Huzhou Third Municipal Hospital from April 2020 to March 2022 and met the enrollment criteria were assigned to tapering off plus CBT-SH (intervention group, n=40), or tapering off alone (control group, n=40). The patients ' mental symptoms, sleep quality, and physical status were assessed before and after intervention, and the withdrawal symptoms were assessed after intervention. The discontinuation rate of BZD and withdrawal symptoms between the two groups were compared after intervention.   Results   At the end of 8th week, the discontinuation rate of BZD in the intervention group was higher than that in the control group [52.5% (21/40) vs. 27.5% (11/40), P=0.017]; the daily dose of BZD in the intervention group was lower than that in the control group [0.0 (0.0, 3.8) mg/d vs. 3.0 (0.0, 4.8) mg/d, P=0.035]. The withdrawal symptoms mainly showed feeling faint, noise sensitivity and dizziness. The frequency of withdrawal symptoms in the intervention group was lower than that in the control group [50.0% (20/40) vs. 77.5% (31/40), P=0.011], the scores of benzodiazepine withdrawal symptom questionnaire (BWSQ) in the intervention group were significantly lower than that in the control group (P<0.05). There were no significant differences in the scores of the 17-item Hamilton depression scale (HAMD-17), Hamilton anxiety scale (HAMA), and Pittsburgh sleep quality index (PSQI) between the two groups (P>0.05). No clinically significant changes were found in somatic indices in all patients.   Conclusion   In patients with stabilized depression disorder, the addition of CBT-SH can be used during the time of benzodiazepine withdrawal to enhance the discontinuation rate of benzodiazepine and reduce withdrawal symptoms.

     

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