Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes

WANG Peng; YIN Dawei; HE Ye; HU Chong; SUN Wen; ZHU Yuyou

doi:10.16766/j.cnki.issn.1674-4152.003662

Volume 22 Issue 9

Sep. 2024

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2024 > 22(9): 1475-1478

WANG Peng, YIN Dawei, HE Ye, HU Chong, SUN Wen, ZHU Yuyou. Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes[J]. Chinese Journal of General Practice, 2024, 22(9): 1475-1478. doi: 10.16766/j.cnki.issn.1674-4152.003662

Citation:

WANG Peng, YIN Dawei, HE Ye, HU Chong, SUN Wen, ZHU Yuyou. Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes[J]. Chinese Journal of General Practice, 2024, 22(9): 1475-1478. doi: 10.16766/j.cnki.issn.1674-4152.003662

Citation:

PDF( 1611 KB)

Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes

doi: 10.16766/j.cnki.issn.1674-4152.003662

WANG Peng¹
, YIN Dawei¹
, HE Ye¹
, HU Chong¹
, SUN Wen²
, ZHU Yuyou^{2
,
,}

1.
Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230036, China

Funds:

62371433

Received Date: 2024-04-04

Abstract

Abstract

Objective In recent years, many studies have shown that many diseases are associated with apolipoprotein E (APOE) gene diversity. The aim of this study is to investigate the predictive value of the APOE gene in acute ischemic stroke (AIS) caused by intracranial vascular stenosis and its role in evaluating its prognosis. Methods A total of 511 patients with acute ischemic stroke admitted to the First Affiliated Hospital of the University of Science and Technology of China from January 2022 to December 2023 were collected. According to the presence or absence of intracranial artery stenosis, they were divided into the intracranial artery stenosis (ICAS) group (317 cases) and the non-intracranial artery stenosis (NCAS) group (194 cases). At the 6-month follow-up, According to whether they carried the APOE-ε4 gene or not, they were further divided into ε4 carrier group (213 cases) and non-ε4 carrier group (298 cases). Variable such as age, gender, comorbidities, blood lipids, lipoprotein, apolipoprotein E (including allele typing), and lipoprotein A were analyzed, along with high-resolution magnetic resonance imaging of the vessel wall. Followed up evaluations were conducted 6 months after the operation, with results tracked via high-definition vessel wall imaging. Results The plasma APOE concentration in the ICAS group was significantly lower than that in the non-intracranial artery stenosis group (r=0.481, P < 0.01). Among the ε4 carriers, 97/213 (45.54%) had a poor prognosis, while 48/298 (16.11%) of non-ε4 carriers experienced poor prognosis at the end of treatment and after 6 months of follow-up, with a significant difference (OR=4.622, 95% CI: 3.512-6.091, P < 0.01). Conclusion Low plasma APOE levels are a risk factor for acute ischemic stroke caused by ICAS, and the APOE-ε4 gene is associated with poor functional prognosis in AIS patients. Combining the APOE-ε4 genotype with high-resolution vessel wall imaging may be valuable in predicting acute ischemic stroke and evaluating functional outcomes.
- Acute ischemic stroke,
- Apolipoprotein E,
- High resolution magnetic resonance imaging,
- Functional assessment,
- Clinical value

FullText(HTML)

References(23)

References

[1]	WANG Z Y, PANG J, ZHOU R Z, et al. Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly[J]. Front Psychiatry, 2023, 14: 1197987. DOI: 10.3389/fpsyt.2023.1197987.
[2]	KHARE H A, BINDERUP T, HAG A M F, et al. Longitudinal imaging of murine atherosclerosis with 2-deoxy-2-[¹⁸F]fluoro-D-glucose and[¹⁸F]-sodium fluoride in genetically modified Apolipoprotein E knock-out and wild type mice[J]. Sci Rep, 2023, 13(1): 22983. DOI: 10.1038/s41598-023-49585-1.
[3]	CASTRO R, GULLETTE S, WHALEN C, et al. High-field magnetic resonance microscopy of aortic plaques in a mouse model of atherosclerosis[J]. MAGMA, 2023, 36(6): 887-896. doi: 10.1007/s10334-023-01102-1
[4]	HUANG Y, RAN X D, LIU H M, et al. A novel dammarane triterpenoid alleviates atherosclerosis by activating the LXRα pathway[J]. Chinese Med, 2023, 18(1): 72. DOI: 10.1186/s13020-023-00758-0.
[5]	RONG X M, CHEN J J, PAN D, et al. Association between Apolipoprotein E genotype and functional outcome in acute ischemic stroke[J]. Aging, 2023, 15(1): 108-118. doi: 10.18632/aging.204460
[6]	SALAH KHLIF M, EGOROVA-BRUMLEY N, BIRD L J, et al. Cortical thinning 3 years after ischaemic stroke is associated with cognitive impairment and APOE ε4[J]. Neuroimage Clin, 2022, 36: 103200. DOI: 10.1016/j.nicl.2022.103200.
[7]	CHEN P Y, QIN L F, SIMONS M. Imaging and Analysis of Oil Red O-Stained whole aorta lesions in an aneurysm hyperlipidemia mouse model[J]. J Vis Exp, 2022(183): 10.3791/61277. DOI: 10.3791/61277.
[8]	ZHAO W N, YIN C H, YU F B, et al. The value of brain structural magnetic resonance imaging combined with APOE-ε4 genotype in early diagnosis and disease progression of senile vascular cognitive impairment no dementia[J]. Contrast Media Mol Imaging, 2022, 2022: 8613024. DOI: 10.1155/2022/8613024.
[9]	PAN W, ZHANG M, GUO Z P, et al. Association between Apolipoprotein E polymorphism and clinical outcome after ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage[J]. Cerebrovasc Dis, 2022, 51(3): 313-322. doi: 10.1159/000520053
[10]	NOVOTNY B C, FERNANDEZ M V, WANG C Y, et al. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer ' s disease brains[J]. Alzheimers Dement, 2023, 19(5): 1785-1799. doi: 10.1002/alz.12800
[11]	付燕林, 吴昌学, 郑菊, 等. N2a/APP695细胞表达载脂蛋白E4对线粒体自噬的影响[J]. 贵州医科大学学报, 2022, 47(5): 497-503. FU Y L, WU C X, ZHENG J, et al. N2a/APP695 cells express apolipoprotein E4 affect mitochondrial autophagy[J]. Journal of Guizhou Medical University, 2022, 47(5): 497-503.
[12]	WANG S Y, RAO J, YUE Y Y, et al. Altered frequency-dependent brain activation and white matter integrity associated with cognition in characterizing preclinical Alzheimer ' s Disease stages[J]. Front Hum Neurosci, 2021, 15: 625232. DOI: 10.3389/fnhum.2021.625232.
[13]	LI L, LI R W, ZACHAREK A, et al. ABCA1/ApoE/HDL signaling pathway facilitates myelination and oligodendrogenesis after stroke[J]. Int J Mol Sci, 2020, 21(12): 4369. DOI: 10.3390/ijms21124369.
[14]	BERSI M R, ACOSTA SANTAMARÍA V A, MARBACK K, et al. Multimodality imaging-based characterization of regional material properties in a murine model of aortic dissection[J]. Sci Rep, 2020, 10(1): 9244. DOI: 10.1038/s41598-020-65624-7.
[15]	BRIDOUX J, NEYT S, DEBIE P, et al. Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging[J]. Molecules, 2020, 25(8): 1838. DOI: 10.3390/molecules25081838.
[16]	QIN X Y, LI J, WU T, et al. Overall and sex-specific associations between methylation of the ABCG1 and APOE genes and ischemic stroke or other atherosclerosis-related traits in a sibling study of Chinese population[J]. Clin Epigenetics, 2019, 11(1): 189-197. doi: 10.1186/s13148-019-0784-0
[17]	HUESO M, CASAS A, MALLÉN A, et al. The double edge of anti-CD40 siRNA therapy: it increases renal microcapillar density but favours the generation of an inflammatory milieu in the kidneys of ApoE-/- mice[J]. J Inflamm (Lond), 2019, 16: 25. DOI: 10.1186/s12950-019-0228-9.
[18]	GUPTA Y, LAMA R K, KWON G R. Prediction and classification of Alzheimer' s Disease based on combined features from apolipoprotein-e genotype, cerebrospinal fluid, MR, and FDG-PET imaging biomarkers[J]. Front Comput Neurosci, 2019, 13: 72. DOI: 10.3389/fncom.2019.00072.
[19]	CLARK D P, HOLBROOK M, LEE C L, et al. Photon-counting cine-cardiac CT in the mouse[J]. PLoS One, 2019, 14(9): e0218417. DOI: 10.1371/journal.pone.0218417.
[20]	王芳, 梅宏斌, 纪军, 等. 急性冠脉综合征合并缺血性脑卒中患者的临床特点[J]. 中华全科医师杂志, 2019, 18(5): 467-469. doi: 10.3760/cma.j.issn.1671-7368.2019.05.013 WANG F, MEI H B, JI J, et al. Clinical features of acute coronary syndrome patients with prior ischemic stroke[J]. Chinese Journal of General Practitioners, 2019, 18(5): 467-469. doi: 10.3760/cma.j.issn.1671-7368.2019.05.013
[21]	王勇胜, 张文杰, 杨明瑞, 等. 高分辨MRI测量大脑中动脉狭窄率的准确性评价[J]. 中华全科医师杂志, 2019, 18(6): 553-557. doi: 10.3760/cma.j.issn.1671-7368.2019.06.009 WANG Y S, ZHANG W J, YANG M R, et al. Accuracy of high resolution MRI in measurement of vascular stenosis ratio in atherosclerotic middle cerebral artery[J]. Chinese Journal of General Practitioners, 2019, 18(6): 553-557. doi: 10.3760/cma.j.issn.1671-7368.2019.06.009
[22]	姚丽娜, 张鹏举. miR-130a通过调控PTEN对缺血性脑卒中神经功能的影响[J]. 贵州医科大学学报, 2021, 46(8): 910-916. YAO L N, ZHANG P J. Effects of mir-130a on neurological function in ischemic stroke by regulating PTEN[J]. Journal of Guizhou Medical University, 2021, 46(8): 910-916.
[23]	PELKA O, FRIEDRICH C M, NENSA F, et al. Sociodemographic data and APOE-ε4 augmentation for MRI-based detection of amnestic mild cognitive impairment using deep learning systems[J]. PLoS One, 2020, 15(9): e0236868. DOI: 10.1371/journal.pone.0236868.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(2) / Tables(5)

Get Citation

PDF

XML

Article Metrics

Article views (32) PDF downloads(3)

Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes

doi: 10.16766/j.cnki.issn.1674-4152.003662

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Application value of apolipoprotein E in predicting acute ischemic death and evaluating functional outcomes

doi: 10.16766/j.cnki.issn.1674-4152.003662

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content