Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1636-1639
CUI Xiaoting, LU Jie, NIU Haoshu, ZHAO Cuijuan. Changes in ERK1/2 signaling pathway in the progression of ulcerative colitis and its association with intestinal opportunistic infections[J]. Chinese Journal of General Practice, 2024, 22(10): 1636-1639. doi: 10.16766/j.cnki.issn.1674-4152.003700
Citation: CUI Xiaoting, LU Jie, NIU Haoshu, ZHAO Cuijuan. Changes in ERK1/2 signaling pathway in the progression of ulcerative colitis and its association with intestinal opportunistic infections[J]. Chinese Journal of General Practice, 2024, 22(10): 1636-1639. doi: 10.16766/j.cnki.issn.1674-4152.003700
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Changes in ERK1/2 signaling pathway in the progression of ulcerative colitis and its association with intestinal opportunistic infections

doi: 10.16766/j.cnki.issn.1674-4152.003700

  • Department of Gastroenterology, Baogang Hospital of Inner Mongolia, Baotou, Inner Mongolia 014010, China

Funds:

 2020MS08024

  • Received Date: 2023-12-11
    Available Online: 2024-12-28
    Abstract
  •   Objective  To observe the changes of extracellular regulatory protein kinase (ERK) 1/2 signaling pathway in the progression of ulcerative colitis (UC) and analyze its association with intestinal opportunistic infection in UC patients.  Methods  A total of 105 UC patients admitted to the gastroenterology department of Baogang Hospital of Inner Mongolia from May 2021 to May 2023 were selected as the study group, and 50 healthy subjects were selected as the control group during the same period, the mRNA transcription levels of ERK-1 and ERK-2 were compared between the two groups. According to the occurrence of intestinal opportunistic infection, 105 UC patients were divided into an infected group and an uninfected group, and the risk factors were screened to analyze the predictive value of UC patients with intestinal opportunistic infection.  Results  The mRNA relative expression levels of ERK-1 and ERK-2 in the study group were higher than those in the control group (P < 0.05), and their changes increased with the progression of UC patients (P < 0.05). Compared with the uninfected group, the disease activity severity rate, hemoglobin, erythrocyte sedimentation rate (ESR) levels, ERK-1 and ERK-2 mRNA transcription levels in the infected group were higher (P < 0.05), and the albumin level was lower (P < 0.05). Severity, decreased albumin and up-regulated expression of ERK-1 mRNA and ERK-2 mRNA were independent risk factors for intestinal opportunistic infections in UC patients. ROC curve results showed that the AUC of ERK-1 mRNA, ERK-2 mRNA, and their combined application model for predicting intestinal opportunistic infection in UC patients were 0.823, 0.835, and 0.907 respectively.  Conclusion  The expression levels of ERK-1 and ERK-2 increased with the progression of UC patients, and they were independent risk factors affecting the occurrence of intestinal opportunistic infections in UC patients, the combined expression levels of ERK-1 and ERK-2 were highly effective in predicting intestinal opportunistic infections in UC patients.

     

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