Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1652-1655
FENG Tao, LIU Gang, YU Xiangtian, LI Min, TAO Jing, LIANG Qisheng. Clinical observation of low-dose esketamine for the prevention and treatment of hyperalgesia after remifentanil general anesthesia[J]. Chinese Journal of General Practice, 2024, 22(10): 1652-1655. doi: 10.16766/j.cnki.issn.1674-4152.003704
Citation: FENG Tao, LIU Gang, YU Xiangtian, LI Min, TAO Jing, LIANG Qisheng. Clinical observation of low-dose esketamine for the prevention and treatment of hyperalgesia after remifentanil general anesthesia[J]. Chinese Journal of General Practice, 2024, 22(10): 1652-1655. doi: 10.16766/j.cnki.issn.1674-4152.003704
shu

Clinical observation of low-dose esketamine for the prevention and treatment of hyperalgesia after remifentanil general anesthesia

doi: 10.16766/j.cnki.issn.1674-4152.003704

  • Department of Anesthesiology, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0785

 2021byzd127

  • Received Date: 2024-02-18
    Available Online: 2024-12-28
    Abstract
  •   Objective  To investigate the effects of low-dose esketamine on the incidence of nociceptive hypersensitivity, pain level, analgesic dosage, and safety after remifentanil general anesthesia.  Methods  Eighty patients who attended the First Affiliated Hospital of Bengbu Medical University for elective radical cervical cancer surgery from December 2021 to September 2022 were selected. The patients were divided into the esketamine group (Group E) and the control group (Group C) using the randomized numerical table method, with 40 cases in each group. The induction and maintenance methods were the same in both groups, with esketamine 0.12 mg/(kg·h) intravenously pumped after induction in Group E and an equal amount of saline pumped in Group C. Mean arterial pressure (MAP) and heart rate (HR) at different time points, incidence of postoperative nociceptive hypersensitivity, time to first pain, immediate VAS score and OAA/S score, postoperative analgesic pump use, and adverse reactions were recorded in both groups.  Results  The MAP at the time points of T3 to T6 in the group E which were higher than that in the group C (P < 0.05); the HR at the time points of T3 to T6 in group E which were higher than that of Group C (P < 0.05); 4 cases of nociceptive allergy appeared in Group E after operation, with an incidence rate of 10%, and 16 cases appeared in the Group C, with an incidence rate of 40%. The incidence rate of nociceptive allergy in the Group E was lower than that in the Group C. The difference was statistically significant (P < 0.05). Compared with group C, the first postoperative pain occurred later in group E [(138.75±16.67) min vs. (40.75±26.16) min], the immediate VAS score was lower (3.35±0.53 vs. 4.60±0.87), and the immediate OAA/S score was higher (4.08±0.76 vs. 3.60±0.93), with statistically significant differences (P < 0.05), and analgesic pump in group E used less medicinal fluid and had satisfactory postoperative analgesia, and the difference was significant (P < 0.05). There is no significant difference in the postoperative adverse reactions between the two groups (P>0.05).  Conclusion  The application of esketamine in patients undergoing radical surgery for cervical cancer resulted in stable intraoperative hemodynamics and satisfactory postoperative analgesia and was able to effectively prevent and control remifentanil-induced nociceptive hypersensitivity.

     

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