Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1696-1699
LU Leilei, GENG Zhusheng. The Clinical Effect of CT-guided Pulse Radiofrequency Combined with Nerve Block in the Treatment of Patients with Head and Face Postherpetic Neuralgia[J]. Chinese Journal of General Practice, 2024, 22(10): 1696-1699. doi: 10.16766/j.cnki.issn.1674-4152.003714
Citation: LU Leilei, GENG Zhusheng. The Clinical Effect of CT-guided Pulse Radiofrequency Combined with Nerve Block in the Treatment of Patients with Head and Face Postherpetic Neuralgia[J]. Chinese Journal of General Practice, 2024, 22(10): 1696-1699. doi: 10.16766/j.cnki.issn.1674-4152.003714
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The Clinical Effect of CT-guided Pulse Radiofrequency Combined with Nerve Block in the Treatment of Patients with Head and Face Postherpetic Neuralgia

doi: 10.16766/j.cnki.issn.1674-4152.003714

  • Department of Pain, the First People ' s Hospital of Lianyungang/ The Affiliated Lianyungang Hospital of Xuzhou Medical University Lianyungang City, Lianyungang, Jiangsu 222000, China

Funds:

 M2020105

  • Received Date: 2024-04-18
    Available Online: 2024-12-28
    Abstract
  •   Objective  To investigate the efficacy and possible mechanism of CT-guided pulse radiofrequency (PRF) combined with nerve block in the treatment of post-herpetic neuralgia (PHN) of the head and face.  Methods  A total of 104 patients with head and face PHN admitted to the First People ' s Hospital of Lianyungang from February 2021 to August 2023 were randomly divided into the study group (52 cases) and the control group (52 cases) using the random number table method. The control group underwent a nerve block procedure. The study group received CT-guided PRF combined nerve block treatment. Efficacy and safety were evaluated after 1 month of treatment, and changes in VAS, Pittsburgh sleep quality index (PSQI), Hamilton anxiety/depression scale (HAMA/HAMD) scores were compared between the two groups before and after treatment. Pain transmitters [β-endorphin (β-EP), substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY)] and inflammatory markers [interleukin-6, IL-26, CC chemokine receptor 2 (CCR2)] were measured in blood samples before and after treatment.  Results  Following treatment, the total effective rate in the study group was significantly higher [90.38% (47/52) vs. 73.08% (38/52), P < 0.05]; Additionally, the VAS score in the study group was (2.21±0.64) points, which was lower than that in the control group [(3.37±1.00) points, F=802.273, P < 0.001]. The PSQI, HAMA, HAMD scores, as well as serum pain transmitters and inflammatory marker levels, were significantly lower in the study group (P < 0.05). Conversely, there was no statistically significant difference in the incidence of adverse reactions (P>0.05).  Conclusion  CT-guided PRF combined with nerve block in the treatment of PHN of the head and face is safe and effective and can reduce pain in patients. The mechanism may be related to inhibition of pain mediators and reduction of serum levels of IL-6, IL-26 and CCR2.

     

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