Volume 22 Issue 10
Oct.  2024
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LYU Mingyan, LIANG Lanyu, SHAN Qing. Correlation between serum creatinine/cystatin C ratio, calf circumference and type 2 diabetes with sarcopenia[J]. Chinese Journal of General Practice, 2024, 22(10): 1709-1713. doi: 10.16766/j.cnki.issn.1674-4152.003717
Citation: LYU Mingyan, LIANG Lanyu, SHAN Qing. Correlation between serum creatinine/cystatin C ratio, calf circumference and type 2 diabetes with sarcopenia[J]. Chinese Journal of General Practice, 2024, 22(10): 1709-1713. doi: 10.16766/j.cnki.issn.1674-4152.003717
shu

Correlation between serum creatinine/cystatin C ratio, calf circumference and type 2 diabetes with sarcopenia

doi: 10.16766/j.cnki.issn.1674-4152.003717

  • Department of Geriatrics, the Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, China

Funds:

 LKM2022024

 AHYZUCXTD202107

  • Received Date: 2024-01-23
    Available Online: 2024-12-28
    Abstract
  •   Objective  To investigate the value of serum creatinine/cystatin C ratio (CCR) combined with calf circumference for screening type 2 diabetes mellitus combined with sarcopenia.  Methods  The data of 276 patients with type 2 diabetes diagnosed in the Department of Endocrinology of the Affiliated Hospital of Yangzhou University from December 2022 to June 2023 were included, and they were divided into a sarcopenia group and a non-sarcopenia group according to the JSH standard. Spearman correlation analysis was used to study the relationship between CCR and indicators affecting sarcopenia. The risk of CCR value affecting the incidence of sarcopenia was analyzed by stepwise regression of binary logistic regression. The receiver operating characteristic (ROC) curve was used to analyze the value of CCR, and calf circumference alone and jointly in screening type 2 diabetes with sarcopenia.  Results  The prevalence of type 2 diabetes mellitus with sarcopenia in this study was 14.13% (39/276). CCR was positively correlated with BMI, urinary creatinine (UCR), erector spinae muscle area (T12 CSA) at the 12th thoracic vertebra level, skeletal muscle mass index (L3 SMI) at the third lumbar vertebra level, and calf circumference (P < 0.05), and negatively correlated with age, CysC and urinary albumin to creatinine ratio (ACR, P < 0.05). The study used two-way stepwise binary logistic regression analysis to obtain BMI, history of diabetes peripheral vascular disease, ACR, CCR, total cholesterol (TC), and calf circumference were all risk factors for type 2 diabetes with sarcopenia (P < 0.05). ROC curve analysis showed that the AUC of CCR combined with calf circumference to predict diabetes with sarcopenia was 0.817, the sensitivity and specificity were 91.1% and 56.4%, respectively, and the Yoden index was 0.475.  Conclusion  CCR and calf circumference are closely related to the occurrence of sarcopenia in diabetes. CCR combined with calf circumference will become an effective indicator for early screening of sarcopenia in patients with type 2 diabetes.

     

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