Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1714-1717
XIA Kun, ZHANG Yong, ZHOU Dan. The correlation between serum KLF2 and S1P1 levels and coronary artery injury in children with Kawasaki disease[J]. Chinese Journal of General Practice, 2024, 22(10): 1714-1717. doi: 10.16766/j.cnki.issn.1674-4152.003718
Citation: XIA Kun, ZHANG Yong, ZHOU Dan. The correlation between serum KLF2 and S1P1 levels and coronary artery injury in children with Kawasaki disease[J]. Chinese Journal of General Practice, 2024, 22(10): 1714-1717. doi: 10.16766/j.cnki.issn.1674-4152.003718
shu

The correlation between serum KLF2 and S1P1 levels and coronary artery injury in children with Kawasaki disease

doi: 10.16766/j.cnki.issn.1674-4152.003718

  • Wuhan Children ' s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430019, China

Funds:

 WJ2021M019

  • Received Date: 2024-05-11
    Available Online: 2024-12-28
    Abstract
  •   Objective  To explore the correlation between Krüppel-like transcription factor 2 (KLF2) and sphingosine 1-phosphate receptor 1 (S1P1) levels and coronary artery injury in children with Kawasaki disease, and the risk factors for coronary artery injury.  Methods  A total of 120 children with Kawasaki disease admitted to Wuhan Children ' s Hospital, Tongji Medical College, Huazhong University of Science and Technology from December 2021 to December 2023 were studied. Serum KLF2 and S1P1 levels were determined, the presence and the degree of coronary artery injury were assessed, and the correlation among serum KLF2, S1P1 levels, and coronary artery injury was analyzed.  Results  The levels of serum KLF2 and S1P1 in children with coronary artery injury were lower than those without injury [(2.48±0.72) vs. (4.29±0.92) pg/mL, (287.65±42.88) vs. (427.64±52.86) ng/mL, P < 0.01]; The levels of serum KLF2 and S1P1 in coronary dilatation group were higher than those in small, medium and large coronary aneurysm group; The levels of serum KLF2 and S1P1 in the small and medium coronary aneurysm group were higher than those in the large coronary aneurysm group; Serum KLF2 and S1P1 levels were negatively correlated with the degree of coronary artery injury (r=-0.522, -0.634; P=0.003, P < 0.001); Multiple Logistic regression analysis showed the duration of fever, white blood cell count, KLF2 and S1P1 were the influencing factors of coronary artery injury in children (P < 0.05).  Conclusion  The levels of serum KLF2 and S1P1 in children with Kawasaki disease with coronary artery injury decrease, and the decreased degree is closely related to the degree of coronary artery injury. The course of fever duration, white blood cell count, and the levels of KLF2 and S1P1 are influential factors for coronary artery injury.

     

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    • References(25)
  • [1]
    闵丽, 王晋, 董湘玉. 人软骨糖蛋白-39、N端脑钠肽前体在川崎病患儿冠状动脉损伤中的应用价值[J]. 实用临床医药杂志, 2024, 28(3): 1-5.

    MIN L, WANG J, DONG X Y. Value of human cartilage glycoprotein-39 and N-terminal prohormone of brain natriuretic peptide in coronary artery injury in children with Kawasaki disease[J]. Journal of Clinical Medicine in Practice, 2024, 28(3): 1-5.
    [2]
    PIRAM M, BURNS J C. Kawasaki disease for the paediatric dermatologist: skin manifestations and new insights into the pathophysiology[J]. Clin Exp Dermatol, 2021, 46(3): 503-509. doi: 10.1111/ced.14558
    [3]
    BURNS J C, ROBERTS S C, TREMOULET A H, et al. Infliximab versus second intravenous immunoglobulin for treatment of resistant Kawasaki disease in the USA (KIDCARE): a randomised, multicentre comparative effectiveness trial[J]. Lancet Child Adolesc Health, 2021, 5(12): 852-861. doi: 10.1016/S2352-4642(21)00270-4
    [4]
    王一铮, 王鹤, 蔡飞, 等. 血府逐瘀胶囊含药血清对人微血管内皮细胞KLF2表达的影响[J]. 中医杂志, 2021, 62(15): 1356-1361.

    WANG Y Z, WANG H, CAI F, et al. Effect of Xuefu Zhuyu Capsule-Containing Serum on the Expression of KLF2 in Human Microvascular Endothelial Cells[J]. Journal of Traditional Chinese Medicine, 2021, 62(15): 1356-1361.
    [5]
    金芙蓉, 潘一红, 瞿向东. 小檗碱对卵巢癌SKOV3细胞S1P/S1PR1通路调控作用及对血管生成的影响[J]. 中国妇幼保健, 2023, 38(4): 712-716.

    JIN F R, PAN Y H, QU X D. Effects of berberine on the regulation of S1P/S1PR1 pathway and angiogenesis in ovarian cancer SKOV3 cells[J]. Maternal & Child Health Care of China, 2023, 38(4): 712-716.
    [6]
    LIN C M, WANG B W, PAN C M, et al. Chrysin boosts KLF2 expression through suppression of endothelial cell-derived exosomal microRNA-92a in the model of atheroprotection[J]. Eur J Nutr, 2021, 60(8): 4345-4355. doi: 10.1007/s00394-021-02593-1
    [7]
    TAKAHASHI H, NAKAGAWA K, YAMADA H, et al. Time course of collateral vessel formation after retinal vein occlusion visualized by OCTA and elucidation of factors in their formation[J]. Heliyon, 2021, 7(1): 1-13.
    [8]
    黄铮, 吴平生. 美国心脏病学会(AHA)川崎病诊断指南[J]. 岭南心血管病杂志, 2003, 9(4): 301-304.

    HUANG Z, WU P S. American Heart Association (AHA) Guidelines for Kawasaki Disease diagnosis[J]. South China Journal of Cardiovascular Diseases, 2003, 9(4): 301-304.
    [9]
    DANIELS L B, GORDON J B, BURNS J C. Kawasaki disease: late cardiovascular sequelae[J]. Curr Opin Cardiol, 2012, 27(6): 572-577. doi: 10.1097/HCO.0b013e3283588f06
    [10]
    陈玉萍, 张兰. 不同炎性指标检测在川崎病患儿诊断中的价值[J]. 中华全科医学, 2020, 18(3): 362-364.

    CHEN Y P, ZHANG L. The value of different inflammatory indicators in children with Kawasaki disease[J]. Chinese Journal of General Practice, 2020, 18(3): 362-364.
    [11]
    王萌, 张瑄, 邢淑华, 等. 血清趋化素水平与川崎病患儿急性期冠状动脉损害的相关研究[J]. 中国临床医生杂志, 2023, 51(11): 1361-1364.

    WANG M, ZHANG X, XING S H, et al. Relationship between serum chemokine level and coronary artery damage in children with Kawasaki disease[J]. Chinese Journal of Clinicians, 2023, 51(11): 1361-1364.
    [12]
    BORDEA M A, COSTACHE C, GRAMA A, et al. Cytokine cascade in Kawasaki disease versus Kawasaki-like syndrome[J]. Physiol Res, 2022, 71(1): 17-27.
    [13]
    CHEN C, CHEN J, TAO X, et al. Activation of GPR30 with G1 inhibits oscillatory shear stress-induced adhesion of THP-1 monocytes to HAECs by increasing KLF2[J]. Aging (Albany NY), 2021, 13(8): 11942-11953.
    [14]
    SU T, YANG Y, LAI S, et al. Single-Cell Transcriptomics Reveals Zone-Specific Alterations of Liver Sinusoidal Endothelial Cells in Cirrhosis[J]. Cell Mol Gastroenterol Hepatol, 2021, 11(4): 1139-1161.
    [15]
    JIANG Y, SHEN Q. IRF2BP2 prevents ox-LDL-induced inflammation and EMT in endothelial cells via regulation of KLF2[J]. Exp Ther Med, 2021, 21(5): 481-494.
    [16]
    LI H, WANG Y, LIU J, et al. Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling[J]. Theranostics, 2021, 11(4): 1609-1625.
    [17]
    陈亮, 柏洁, 郑扣龙. KLF2在急性冠脉综合征中的作用研究[J]. 南京医科大学学报(自然科学版), 2022, 42(3): 345-351.

    CHEN L, BAI J, ZHENG K L. The role of KLF2 in acute coronary syndrome[J]. Journal of Nanjing Medical University, 2022, 42(3): 345-351.
    [18]
    NITZSCHE A, POITTEVIN M, BENARAB A, et al. Endothelial S1P1 Signaling Counteracts Infarct Expansion in Ischemic Stroke[J]. Circ Res, 2021, 128(3): 363-382.
    [19]
    BAEYENS A, BRACERO S, CHALUVADI VS, et al. Monocyte-derived S1P in the lymph node regulates immune responses[J]. Nature, 2021, 592(7853): 290-295.
    [20]
    ALSHAIKH R A, RYAN K B, WAEBER C. Sphingosine 1-phosphate, a potential target in neovascular retinal disease[J]. Br J Ophthalmol, 2022, 106(9): 1187-1195.
    [21]
    任宏强, 刘益均, 罗贵全, 等. 1-磷酸鞘氨醇1型受体促进小鼠颈动脉损伤后血管内膜增生[J]. 第三军医大学学报, 2021, 43(3): 202-210.

    REN H Q, LIU Y J, LUO G Q, et al. Sphingosine-l-phosphate type 1 receptor aggravates neointimal hyperplasia after carotid artery injury in mice[J]. Journal of Army Medical University, 2021, 43(3): 202-210.
    [22]
    钱翠平, 黄晓碧, 赵胜, 等. 儿童川崎病冠状动脉损伤危险因素logistic回归分析[J]. 安徽医科大学学报, 2023, 58(3): 490-494.

    QIAN C P, HUANG X B, ZHAO S, et al. Regression analysis of risk factors related to coronary artery lesion in children with Kawasaki disease[J]. Acta Universitatis Medicinalis Anhui, 2023, 58(3): 490-494.
    [23]
    胡红梅, 邱云, 谢帅, 等. 川崎病并发冠状动脉损伤的危险因素及预测因子研究[J]. 保健医学研究与实践, 2023, 20(8): 71-75.

    HU H M, QIU Y, XIE S, et al. Risk factors and predictors of coronary artery lesion in children with Kawasaki disease[J]. Health Medicine Research and Practice, 2023, 20(8): 71-75.
    [24]
    孙书丽, 何鑫. 川崎病患儿血清生长分化因子-15趋化素及正五聚蛋白3水平与炎症细胞因子冠状动脉损伤的相关性[J]. 中国妇幼保健, 2021, 36(15): 3497-3501.

    SUN S L, HE X. Study on the relationship between serum levels of growth differentiation factor-15 and chemokine and pentapmerin 3 and inflammatory factors and coronary artery in-jury in Kawasaki disease children[J]. Maternal & Child Health Care of China, 2021, 36(15): 3497-3501.
    [25]
    CHEN L, SHANGGUAN Z, DONG Z, et al. NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease[J]. Hematology, 2023, 28(1): 227-239.
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