Volume 22 Issue 10
Oct.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(10): 1765-1768
ZHOU Na, JIANG Feng, LIU Ruibao. The clinical study of modified Wuling Powder Combined with conbercept in the treatment of diabetic macular edema of liver depression and spleen deficiency[J]. Chinese Journal of General Practice, 2024, 22(10): 1765-1768. doi: 10.16766/j.cnki.issn.1674-4152.003729
Citation: ZHOU Na, JIANG Feng, LIU Ruibao. The clinical study of modified Wuling Powder Combined with conbercept in the treatment of diabetic macular edema of liver depression and spleen deficiency[J]. Chinese Journal of General Practice, 2024, 22(10): 1765-1768. doi: 10.16766/j.cnki.issn.1674-4152.003729
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The clinical study of modified Wuling Powder Combined with conbercept in the treatment of diabetic macular edema of liver depression and spleen deficiency

doi: 10.16766/j.cnki.issn.1674-4152.003729
  • 1.

    Ophthalmology Department, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 471000, China

Funds:

 2022ZY1010

  • Received Date: 2024-03-19
    Available Online: 2024-12-28
    Abstract
  •   Objective  To examine the clinical impact of a modified Wuling Powder combined with Conbercept on diabetic macular edema (DME) in patients with liver depression and spleen deficiency.  Methods  The study subjects were 86 patients (86 eyes) with DME of liver depression and spleen deficiency treated in the Department of Ophthalmology at the First Affiliated Hospital of Henan University of Chinese Medicine between December 2020 and May 2023. The subjects were randomly assigned to either the observation group (n=43, modified Wuling Powder combined with Conbercept) and the control group (n=43, Conbercept) using a random number table method. A comparison was made of the clinical efficacy, traditional Chinese medicine (TCM) syndrome score, visual acuity level, macular thickness, serum factor level and incidence of adverse reactions in the two groups. The statistical analysis was conducted using SPSS 22.0 software.  Results  The observation group exhibited higher total effective rate [95.35% (43/43) vs. 81.40% (35/43)] 3 months following treatment (χ2=4.074, P=0.044). The TCM syndrome scores, visual acuity levels, macular thickness indexes, interleukin-6 and vascular endothelial growth factor levels in both groups decreased, with the observation group exhibiting lower levels (P < 0.05), conversely, the nitric oxide synthase levels increased in both groups, with the observation group demonstrating higher levels (P < 0.05). With regard to adverse reactions, no statistically significant difference was observed between the two groups [9.30% (4/43) vs. 11.63% (5/43), P>0.05].  Conclusion  The combination of modified Wuling Powder with Conbercept has been demonstrated to be an effective treatment for DME caused by hepatic depression and splenic deficiency. It has the capacity to significantly improve the clinical symptoms of patients, enhance their visual acuity, reduce macular thickness, alleviate inflammatory response, and improve vascular endothelial function. Furthermore, it has been shown to be a safe treatment option.

     

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