Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1837-1841
FAN Yongqi, YANG Dandan, ZHANG Qiqi, YAN Bo, ZHANG Zhiguo. Embryonic development and clinical outcomes in patients with 0PN zygote derived embryos[J]. Chinese Journal of General Practice, 2024, 22(11): 1837-1841. doi: 10.16766/j.cnki.issn.1674-4152.003745
Citation: FAN Yongqi, YANG Dandan, ZHANG Qiqi, YAN Bo, ZHANG Zhiguo. Embryonic development and clinical outcomes in patients with 0PN zygote derived embryos[J]. Chinese Journal of General Practice, 2024, 22(11): 1837-1841. doi: 10.16766/j.cnki.issn.1674-4152.003745
shu

Embryonic development and clinical outcomes in patients with 0PN zygote derived embryos

doi: 10.16766/j.cnki.issn.1674-4152.003745
  • 1.

    Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Funds:

 2022YFC2703000

 82071724

  • Received Date: 2024-03-17
    Available Online: 2024-12-31
    Abstract
  •   Objective  The cause of abnormal fertilization and embryo development in non-pronucleus (0PN) zygotes remains unclear, and the viability of transferring 0PN zygotes is still controversial. The study aims to explore the clinical utility of 0PN zygote-derived embryos.  Methods  A total of 9 167 IVF/ICSI cycles conducted between September 2019 and May 2022 were analyzed. (1) Embryo development and clinical outcomes were compared between 6 915 cycles with at least one OPN fertilization (2PN/0PN) and 2 252 cycles with all embryos from 2PN fertilization (2PN group). (2) Patients were further categorized based on the proportion of 0PN-derived embryos in IVF cycles: L group (0-30%, n=2 579), M group (31%-60%, n=782), and H group (61%-100%, n=221), with embryo development and clinical outcomes compared across groups. (3) Embryo development and clinical outcomes were also compared with complete 0PN (0PN 100% group) and complete 2PN (2PN 100% group).  Results  (1) The blastocyst formation rate of 2PN group was significantly higher than that of the 2PN/0PN group (62.44% vs. 55.01%, P < 0.001), whereas the cumulative live birth rate (CLR) of 2PN group was significantly lower than the 2PN/0PN group (54.97% vs. 64.99%, P < 0.001). There was no significant difference in neonatal weight or Apgar score between the two groups. (2) The number of oocytes retrieved, fertilization rate, cumulative clinical pregnancy rate (CCR), and CLR decreased progressively across L, M, and H. The cleavage rate of group M was significantly higher than that in the other two groups. H group had significantly higher rates of high-quality embryos, blastocyst formation, and top-grade cysts compared to the group L. (3) The live birth rate for 0PN-derived embryos (0PN 100% group) was significantly lower than for 2PN-derived embryos (2PN 100% group, 30.56% vs. 60.00%, P < 0.001), though there was no significant difference in clinical outcomes after blastocyst transfer between the two groups (P>0.05).  Conclusion  Clinical pregnancy outcomes after transferring 0PN-derived embryos did not show increased risk of miscarriage or adverse neonatal. Therefore, transferring 0PN-derived embryos may be a feasible option when normal blastocysts are unavailable.

     

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