Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1876-1879
CHEN Juan, CHEN Shixuan, WANG Feng, HUANG Wenwen. Correlation analysis between serum iron-related indicators and risk of post-stroke cognitive impairment in stroke patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1876-1879. doi: 10.16766/j.cnki.issn.1674-4152.003754
Citation: CHEN Juan, CHEN Shixuan, WANG Feng, HUANG Wenwen. Correlation analysis between serum iron-related indicators and risk of post-stroke cognitive impairment in stroke patients[J]. Chinese Journal of General Practice, 2024, 22(11): 1876-1879. doi: 10.16766/j.cnki.issn.1674-4152.003754
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Correlation analysis between serum iron-related indicators and risk of post-stroke cognitive impairment in stroke patients

doi: 10.16766/j.cnki.issn.1674-4152.003754

  • Department of Neurosurgery, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2021ZB276

  • Received Date: 2024-02-27
    Available Online: 2024-12-31
    Abstract
  •   Objective  To explore the correlation between serum iron (SI) related indexes and the risk of post-stroke cognitive impairment (PSCI), providing a theoretical basis for clinical intervention in PSCI.  Methods  A retrospective analysis was conducted on the clinical data of 281 stroke patients treated at Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from February 2021 to July 2023. Cognitive function was evaluated by Montreal cognitive assessment scale (MoCA). According to the results of MoCA score, the score of < 26 was set as the PSCI group, and the score of ≥26 was set as the non-PSCI group. The general data, serum iron-related indexes, neurological evaluations, and imaging-related data were collected and compared between the two groups. The related factors affecting PSCI were analyzed by multivariate logistic regression.  Results  Among the 281 stroke patients, 124 patients developed PSCI, with an incidence rate of 44.13%. Significant differences were observed in age and Hb between the two groups (P < 0.05). SI, serum ferritin (SF), transferrin (TRF), total iron binding capacity (TIBC), transferrin saturation (TSAT), and hepcidin (Hep) were compared between the two groups, with statistically significant differences (P < 0.05). There were significant differences in National Institute of Health stroke scale (NIHSS) score, infarct volume, and perivascular space expansion rate between the two groups (P < 0.05). Multivariate logistic regression analysis showed that higher levels of Hb, SI, TRF, and TIBC were independent protective factors against PSCI, while elevated SF, Hep levels, high NIHSS scores, increased infarct volume, and enlarged perivascular spaces were independent risk factors for PSCI.  Conclusion  The risk of PSCI is significant, and serum iron-related indexes such as SI, TRF, and TIBC are closely associated with its development.

     

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