Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1884-1886
YANG Jianxiang, LIN Yongqiang. The long-term improvement effect of high flux hemodialysis on cardiac function ultrasound index, serum myocardial injury and inflammatory biochemical index in elderly patients with diabetic nephropathy[J]. Chinese Journal of General Practice, 2024, 22(11): 1884-1886. doi: 10.16766/j.cnki.issn.1674-4152.003756
Citation: YANG Jianxiang, LIN Yongqiang. The long-term improvement effect of high flux hemodialysis on cardiac function ultrasound index, serum myocardial injury and inflammatory biochemical index in elderly patients with diabetic nephropathy[J]. Chinese Journal of General Practice, 2024, 22(11): 1884-1886. doi: 10.16766/j.cnki.issn.1674-4152.003756
shu

The long-term improvement effect of high flux hemodialysis on cardiac function ultrasound index, serum myocardial injury and inflammatory biochemical index in elderly patients with diabetic nephropathy

doi: 10.16766/j.cnki.issn.1674-4152.003756
  • 1.

    Ultrasound Department, Wenzhou Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

 2023ZL676

  • Received Date: 2024-05-10
    Available Online: 2024-12-31
    Abstract
  •   Objective  High-flux hemodialysis (HFHD) was performed in elderly patients with diabetic nephropathy (DN) maintenance hemodialysis (MHD) to evaluate the long-term improvement of cardiac function ultrasound index, serum myocardial injury, and inflammatory biochemical index.  Methods  A total of 93 elderly patients with DN who received MHD treatment in Wenzhou Chinese and Western Medicine Hospital from March 2022 to March 2023 were selected and divided into a HFHD group (n=42) and a low-flux dialysis (LFHD) group (n=51) according to patients' needs and dialysis purposes. High-flux dialysis and low-flux dialysis were performed respectively, and the treatment effect was followed up for 1 year. At the end of the follow-up period, the differences in cardiac function ultrasound indexes, serum myocardial injury, inflammatory biochemical indexes, and incidence of adverse reactions were compared between the two groups.  Results  The results of intra-group comparison showed that; after treatment, the left ventricular end-diastolic diameter (LVDD) in the HFHD group decreased, the left ventricular ejection fraction (LVEF%) and the ratio of early diastolic E peak to late diastolic A peak (E/A) increased, and the serum high-sensitivity troponin Ⅰ (hs-TNⅠ) level also showed an upward trend (P < 0.05). The levels of hs-TNⅠ, Hcy, and hs-CRP in the LFHD group were significantly increased (P < 0.05). The results of inter-group comparison showed that after the treatment, LVDD and interventricular septum diastolic thickness (IVSDT) in the HFHD group were significantly lower than those in the LFHD group, while LVEF% and E/A were significantly higher than those in the LFHD group. The levels of serum creatine kinase isoenzyme mass (CK-MBmass), hs-TNⅠ, homocysteine (Hcy), and hypersensitive C-reactive protein (hs-CRP) in the HFHD group were significantly lower than those in the LFHD group. The total incidence of dialysis adverse reactions in the HFHD group was 11.90% (5/42), which was significantly lower than that in the LFHD group (47.06%, 24/51, P < 0.001).  Conclusion  HFHD treatment in elderly DN MHD patients can effectively improve cardiac function and delay myocardial injury with high safety.

     

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