Volume 22 Issue 11
Nov.  2024
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Article Navigation >  Chinese Journal of General Practice  > 2024  >  22(11): 1921-1923
SHI Tianliang. Study on the clinical effect of three-dimensional amide proton transfer imaging and diffusion-weighted imaging for diagnosis and prognosis evaluation of cervical cancer[J]. Chinese Journal of General Practice, 2024, 22(11): 1921-1923. doi: 10.16766/j.cnki.issn.1674-4152.003765
Citation: SHI Tianliang. Study on the clinical effect of three-dimensional amide proton transfer imaging and diffusion-weighted imaging for diagnosis and prognosis evaluation of cervical cancer[J]. Chinese Journal of General Practice, 2024, 22(11): 1921-1923. doi: 10.16766/j.cnki.issn.1674-4152.003765
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Study on the clinical effect of three-dimensional amide proton transfer imaging and diffusion-weighted imaging for diagnosis and prognosis evaluation of cervical cancer

doi: 10.16766/j.cnki.issn.1674-4152.003765

  • Department of radiology, Tongren People' s Hospital, Tongren, Guizhou 554300, China

Funds:

 gzwkj2021-374

  • Received Date: 2024-06-06
    Available Online: 2024-12-31
    Abstract
  •   Objective  This study aims to explore the potential value of 3D amide proton transfer imaging (3D-APT) in the diagnosis and treatment of cervical cancer by comparing its differences in the qualitative diagnosis and prognostic evaluation of cervical tissue lesions with diffusion-weighted image (DWI).  Methods  A total of 260 patients with cervical lesions, admitted to Tongren People' s Hospital from December 2020 to December 2021, were selected as the study subjects. All subjects underwent MR scanning, including 3D-APT and DWI sequence scans. The tissue pathology test were used as the gold standard to evaluate the diagnostic efficacy of both MR imaging techniques for cervical tissue lesions. The study analyzed the correlation between imaging indicators from both techniques and changes in tumor diameter after radiotherapy and chemotherapy, as well as progression-free survival.  Results  The sensitivity, specificity, and accuracy of 3D-APT for distinguishing benign from malignant cervical lesions were 98.91%, 99.40%, and 99.23%, respectively, while for DWI they were 95.70%, 98.20%, and 97.31%. The differences between the two techniques were not statistically significant (P>0.05). The correlation coefficient (r=0.824) between changes in 3D-APT indicators (ΔAPT) and reduction in maximum lesion diameter after radiotherapy and chemotherapy was higher than that of DWI indicators (r=0.781). The correlation coefficient between the 3D-APT index (APT) and progression-free survival in cervical cancer patients before radiotherapy and chemotherapy (r=-0.863) was higher than that of DWI index (DWI, r=0.795).  Conclusion  Compared to DWI examination, 3D-APT demonstrates superior capabilities in both the qualitative diagnosis and prognostic evaluation of cervical tissue lesions.

     

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